Abstract: A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.

Abstract: In a method of service emulation, a plurality of messages communicated between a system under test and a target system for emulation are recorded in a computer-readable memory. Ones of the messages are clustered to define a plurality of message clusters, and respective cluster prototypes are generated for the message clusters. The respective cluster prototypes include a commonality among the ones of the messages of the corresponding message clusters. One of the message clusters is identified as corresponding to a request from the system under test based on a comparison of the request with the respective cluster prototypes, and a response to the request for transmission to the system under test is generated based on the one of the message clusters that was identified. Related computer systems and computer program products are also discussed.

Abstract: In a service emulation method, a transaction library storing a plurality of messages communicated between a system under test and a target system upon which the system under test depends is accessed responsive to receiving a request from the system under test. One of the messages stored in the transaction library is identified as corresponding to the received request based on a distance measure therebetween, and a response to the received request is generated using the one of the messages that was identified. Related systems and computer program products are also discussed.

Abstract: In a method of service emulation, a plurality of messages communicated between a system under test and a target system for emulation are recorded in a computer-readable memory. Ones of the messages are clustered to define a plurality of message clusters, and respective cluster prototypes are generated for the message clusters. The respective cluster prototypes include a commonality among the ones of the messages of the corresponding message clusters. One of the message clusters is identified as corresponding to a request from the system under test based on a comparison of the request with the respective cluster prototypes, and a response to the request for transmission to the system under test is generated based on the one of the message clusters that was identified. Related computer systems and computer program products are also discussed.

Abstract: In a method of service emulation, ones of a plurality of messages communicated between a system under test and a target system for emulation are clustered into message clusters. A request is received from the system under test, and one of the message clusters is identified as corresponding to the request based on a distance measure. A response to the request is generated using the one of the message clusters that was identified. Related computer systems and computer program products are also discussed.

Abstract: In a service emulation method, a transaction library storing a plurality of messages communicated between a system under test and a target system upon which the system under test depends is accessed responsive to receiving a request from the system under test. One of the messages stored in the transaction library is identified as corresponding to the received request based on a distance measure therebetween, and a response to the received request is generated using the one of the messages that was identified. Related systems and computer program products are also discussed.

Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.

Abstract: Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.

Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.

Abstract: The present invention relates to certain esters of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1 and R2 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.

Abstract: Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.

Abstract: A running string for a subsea completion comprises an upper section (70) which may be a coiled tubing (CT) injector unit as shown, or a wireline lubricator (FIG. 8). A lower section (60) provides wireline/CT access to production/annulus bores of a tubing hanger (not shown) attached to tubing hanger running tool (62). A flow package (64) in the lower section (60), together with BOP pipe rams (86) and annular seal (88), directs production and annulus fluid flows/pressures to the BOP choke/kill lines (78/76). The upper and lower sections allow installation and pressure/circulation testing of, and wireline/CT access to, a subsea completion, without the use of a high pressure riser.

Abstract: Piston-cylinder assembly, comprising a container tube, in which a piston rod is guided with freedom of axial movement, which rod is at least partially covered by a sheath tube with at least one elastic fold, where a resilient stop pad is provided concentrically to the piston rod, the end of which pad comes to rest against an end cap during the inward travel of the piston rod, which end cap rests against the container tube in the fully assembled piston rod assembly. The stop pad, the sheath tube, and the end cap form a preassembled unit which is independent of the piston rod assembly, the end cap being pressed onto the container tube by the resilient stop pad during the inward travel of the piston rod into the container tube.

Abstract: A completion system comprises a christmas tree (10) mounted on a wellhead housing (11), a tubing hanger (12) landed in the tree or wellhead housing, the wellhead housing (11) being mounted on a casing string (100) and a tubing string (14) being suspended from the tubing hanger within the casing string; wherein, in use, the annulus defined between the tubing (14) and the casing (100) serves as a production bore. A second tubing string (98) is expanded into sealing engagement with the casing string (100) over at least a portion of their lengths. The annulus normally used to provide well service functions is thus eliminated. Well servicing is instead provided via the tubing string (14), which may be coiled tubing.

Abstract: A horizontal Christmas tree is adapted for ESP/HSP or downhole sensor deployment by a coiled tubing hanger 38 received in the tubing hanger 12. Coiled tubing 40 suspends downhole equipment such as ESP 60, and carries power/signal lines. These lines are connected to an external line 58 via a transition connector 46 in a tubing access plug 44 provided in an internal tree cap 32. A debris cap 50 is provided with a further connector 52. Self orientating wet mate connectors 48, 54, 56 are provided between the connectors 46, 52 and external line 58. The coiled tubing hanger and/or tubing hanger may be provided with flow by flutes or holes (78, 80 FIGS. 4 and 5) sealable by a separate adapter plug (88, FIG. 5) above the coiled tubing hanger. Flow test procedures are also disclosed.

Abstract: The invention provides compounds of formula (I), wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents H or C1-6 alkoxy optionally substituted by one or more fluorine atoms; R3 represents one or more groups independently selected from H, halogen, C1-4 alkoxy and CF3; in addition, R2 and one R3 group may together represent —OCH2—, the methylene group being attached to the ortho-position of the pendant phenyl ring; R4 represents a 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and the pharmaceutically acceptable salts thereof.

Abstract: A completion system comprises a christmas tree (10) mounted on a wellhead housing (11), a tubing hanger (12) landed in the tree or wellhead housing, the wellhead housing (11) being mounted on a casing string (100) and a tubing string (14) being suspended from the tubing hanger within the casing string; wherein, in use, the annulus defined between the tubing (14) and the casing (100) serves as a production bore. A second tubing string (98) is expanded into sealing engagement with the casing string (100) over at least a portion of their lengths. The annulus normally used to provide well service functions is thus eliminated. Well servicing is instead provided via the tubing string (14), which may be coiled tubing.

Abstract: Compounds of formula I, 1

Abstract: The invention provides compounds of formula (I), 1

Abstract: Compounds of formula I, wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents an aryl group or a heteroaryl group, optionally substituted by C1-4 alkyl or SO2NH2; R3 represents a 4-, 5-, 6-, or 7-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent, or represents a cyclic group of formula Ia,  or represents a chain of formula Ib,  and pharmaceutically acceptable salts thereof, are useful in the treatment of a variety of disorders including benign prostatic hyperplasia.