Abstract: The systems, methods, devices and kits disclosed herein be used to determine the presence and/or level a target analyte(s) in a biological sample, wherein the analyte(s) is associated with a pathogenic (e.g., a viral antigen or whole virus) or otherwise altered physiological condition (e.g., pregnancy). In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the RT-PCT and lateral flow antibody assays known in the art for the detection of SARS-CoV-2, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof.

Abstract: Systems and methods for imaging and tracking fibrin formation via interaction of a test sample with a clotting agent or for imaging and tracking fibrin removal by an anti-clotting agent are described.

Abstract: Disclosed herein are polyamine transport inhibitors (PTI) and methods of use as antivirals. Disclosed PTI compounds are useful as treatments for viral infections or can be used as prophylactic agents that protect high risk individuals from becoming infected by the virus. The disclosed PTI compounds can be used alone or in combination with other agents (or other antivirals) to improve patient outcomes such as DFMO (or Remdesivir).

Abstract: Disclosed herein are polyamine transport inhibitors (PTI) and methods of use as antivirals. Disclosed PTI compounds are useful as treatments for viral infections or can be used as prophylactic agents that protect high risk individuals from becoming infected by the virus. The disclosed PTI compounds can be used alone or in combination with other agents (or other antivirals) to improve patient outcomes such as DFMO (or Remdesivir).

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a user's control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a user's control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: Provided herein are novel small molecule pyridomyrimidone viral inhibitor agents of Formula (I), such as 4-acetyl-2,3,7,8-tetrahydro-3-phenylpyrido[1,2-f]pyrimidin-1-one, and methods of using pharmaceutical or therapeutic compositions comprising such viral inhibitor agents of Formula (I) in inhibiting and treating viral infections including orthopox and retroviral infections. Methods of synthesizing such agents are also provided herein.

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: A laminate interconnect structure includes a core material and at least one additional layer adjacent the core material, a first electrically conductive via formed in the core material, and a second electrically conductive via formed in the core material, coaxial with the first electrically conductive via and separated from the first electrically conductive via by a non-conductive material.

Abstract: Provided herein are novel small molecule pyridomyrimidone viral inhibitor agents of Formula (I), such as 4-acetyl-2,3,7,8-tetrahydro-3-phenylpyrido[1,2-f]pyrimidin-1-one, and methods of using pharmaceutical or therapeutic compositions comprising such viral inhibitor agents of Formula (I) in inhibiting and treating viral infections including orthopox and retroviral infections. Methods of synthesizing such agents are also provided herein.

Abstract: A laminate interconnect structure includes a core material and at least one additional layer adjacent the core material, a first electrically conductive via formed in the core material, and a second electrically conductive via formed in the core material, coaxial with the first electrically conductive via and separated from the first electrically conductive via by a non-conductive material.

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: The present invention provides for x-ray imaging and ultrasound imaging of a body region of interest in a spatially correlatable manner. The resultant x-ray and ultrasound images may be combinatively employed to provide three-dimensional information regarding a location of interest within the body, and is particularly apt for use in the analysis/biopsy of potential lesions and suspicious masses in a female breast. The invention provides for direct body contact by an ultrasound imaging head, as well as targeted ultrasound imaging of a selected portion of the region from which x-ray images are obtained. A user interface system facilitates various procedures including ultrasound guided needle biopsy procedures.

Abstract: Disclosed is a fuser member comprising a substrate, a layer thereover comprising a polymer or an elastomer, and, on the layer, a coating including mercapto- and amino-functionalities comprising from about 0.05 mole percent to about 1.00 mole percent mercapto groups and from about 0.0001 mole percent to about 0.06 mole percent amino groups, wherein the ratio of mercapto to amino mole percent values is at least 2. The layer preferably is a fluoropolymer or fluoroelastomer filled with a metal oxide (CuO, Al2O3, etc.).

Abstract: An ESD protection circuit including the following: one or more inverters (I1, I2, I3), each of the one or more inverters having an input and an output; an RC network (11) having an output node (RCT), output node (RCT) connected with the input of at least one of said one or more inverters; a clamping device (N3) joined with the output of at least one of one or more inverters (I1, I2, I3); and a feedback device (NKP) in communication with clamping device (N3) and output node (RCT) of RC network (11). An RC network may include one or more resistors, and one or more decoupling capacitors. In one embodiment, feedback device (NKP) is an NFET and each of one or more inverters (I1, I2, I3) includes a PFET and NFET pair (P0/N0, P1/N1, P2/N2).

Abstract: An ESD protection circuit including the following: one or more inverters (I1, I2, I3), each of the one or more inverters having an input and an output; an RC network (11) having an output node (RCT), output node (RCT) connected with the input of at least one of said one or more inverters; a clamping device (N3) joined with the output of at least one of one or more inverters (I1, I2, I3); and a feedback device (NKP) in communication with clamping device (N3) and output node (RCT) of RC network (11). An ESD protection circuit according to claim 7, wherein said RC network includes one or more resistors, and one or more decoupling capacitors. In one embodiment, feedback device (NKP) is an NFET and each of one or more inverters (I1, I2, I3) includes a PFET and NFET pair (P0/N0, P1/N1, P2/N2).

Abstract: Disclosed is a fuser member comprising a substrate, a layer thereover comprising a polymer or an elastomer, and, on the layer, a coating including mercapto- and amino-functionalities comprising from about 0.05 mole percent to about 1.00 mole percent mercapto groups and from about 0.0001 mole percent to about 0.06 mole percent amino groups, wherein the ratio of mercapto to amino mole percent values is at least 2. The layer preferably is a fluoropolymer or fluoroelastomer filled with a metal oxide (CuO, Al2O3, etc.).

Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.