Patents by Inventor John Cooke Hodges

John Cooke Hodges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLO[6.1.0]NON-4-YNE REGENTS FOR CHEMICAL MODIFICATION OF OLIGONUCLEOTIDES
    Publication number: 20130066063
    Abstract: The present invention provides for compounds of Formulae I and II: wherein 1R, 2R, L, X, q, Z, A, and B have any of the values disclosed in the specification. Compounds of Formulae I and II are useful as reagents to introduce bicyclo[6.1.0]non-4-yne groups into oligonucleotide chains to serve as points of attachment for chemical tags.
    Type: Application
    Filed: September 7, 2012
    Publication date: March 14, 2013
    Inventors: John Cooke Hodges, Floris Louis van Delft, Sander Sebastiaan Van Berkel, Jorge Verkade, Lana L. Berry
  • PHOSPHORAMIDITE DERIVATIVES OF FOLIC ACID
    Publication number: 20120035362
    Abstract: The present invention provides for compounds of Formula I: wherein L and R1-R6 have any of the values defined there for in the specification. The compounds of formula I are useful as reagents to form folic acid conjugates with hydroxyl-containing compounds of interest, such as oligonucleotides and anti-cancer compounds.
    Type: Application
    Filed: August 1, 2011
    Publication date: February 9, 2012
    Applicant: Berry and Associates, Inc.
    Inventors: Nancy Sue Barta, John Cooke Hodges
  • N-substituted glutamic acid derivatives with interleukin-1.beta. converting enzyme inhibitory activity
    Patent number: 5932549
    Abstract: The present invention relates to N-substituted derivatives of glutamic acid of pharmaceutical interest, to pharmaceutical compositions which include compounds of the invention and pharmaceutically acceptable carriers, to methods of their preparation, and to their use in purification of interleukin-1.beta. converting enzyme (ICE).
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: August 3, 1999
    Assignees: Warner-Lambert Company, BASF Aktiengesellschaft
    Inventors: Hamish John Allen, Subhashis Banerjee, Kenneth Dale Brady, John Cooke Hodges, Catherine Rose Kostlan, Robert Vincent Talanian
  • Solid phase preparation of amines
    Patent number: 5932696
    Abstract: A method for the solid phase preparation of an amine by a novel synthesis is described where a diol is monoalkylated with a chloromethyl resin followed by reaction with N,N'-carbonyldimidazole to afford a resin-bound tertiary-alkoxycarbonyl-imidazole which is subsequently N-alkylated and then sequentially treated with appropriate building blocks and reagents to afford a resin-bound amine which affords the desired amine after treatment with an acid as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: August 3, 1999
    Assignee: Warner-Lambert Company
    Inventors: John Cooke Hodges, Andres Sergio Hernandez
  • Solid phase preparation of amines
    Patent number: 5869579
    Abstract: A method for the solid phase preparation of an amine by a novel synthesis is described where a diol is monoalkylated with a chloromethyl resin followed by reaction with N,N'-carbonyldimidazole to afford a resin-bound tertiary-alkoxycarbonyl-imidazole which is subsequently N-alkylated and then sequentially treated with appropriate building blocks and reagents to afford a resin-bound amine which affords the desired amine after treatment with an acid as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: February 9, 1999
    Assignee: Warner-Lambert Company
    Inventors: John Cooke Hodges, Andres Sergio Hernandez
  • Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
    Patent number: 5830868
    Abstract: Novel inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: November 3, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, Mark Wallace Creswell, John Cooke Hodges, Michael William Wilson
  • Substituted tetra- and pentapeptide inhibitors of protein: farnesyl transferase
    Patent number: 5763577
    Abstract: Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 9, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, Alfred Campbell, Richard Gowan, John Cooke Hodges, Donald Hupe, Daniele Leonard, Tomi Sawyer, Judith Sebolt-Leopold, Francis J. Tinney
  • N-substituted glutamic acid derivatives with interleukin-1 .beta. converting enzyme inhibitory activity
    Patent number: 5744451
    Abstract: The present invention relates to N-substituted derivatives of glutamic acid of pharmaceutical interest, to pharmaceutical compositions which include compounds of the invention and pharmaceutically acceptable carriers, to methods of their preparation, and to their use in purification of interleukin-1.beta. converting enzyme (ICE).
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: April 28, 1998
    Assignees: Warner-Lambert Company, BASF A.G.
    Inventors: Hamish John Allen, Subhashis Banerjee, Kenneth Dale Brady, John Cooke Hodges, Catherine Rose Kostlan, Robert Vincent Talanian