Abstract: A non-injurious restraint for securing a person to an object comprising a flexible strap comprised of, or including a substantially cut-resistant webbing associated with a strip of steel interlinked rings and reinforcement cables. A locking mechanism including one or more projections or pins adapted to engage the interlinked rings in forming a fixed length loop. The strap adapted to be secured to the object with the loop adjusted to encircle the limb, and wherein the locking mechanism locks the length of the loop. A webbing for use in such restraints.

Abstract: A pavement composition includes a recycled hot mix asphalt (HMA) sheet mix composition including more than 50% and up to 100% recycled fines mixed with a rejuvenating agent. The recycled fines of the HMA sheet mix are separated from a reclaimed asphalt pavement (RAP) composition and substantially all of the recycled fines are capable of passing through a sieve having an opening size of ? inch (9.5 mm). Pavement systems include an existing pavement layer and a thin-lift overlay made of the recycled HMA sheet mix on the existing pavement layer. Pavement systems also include a three-layer system including a leveling course layer, an interlayer, and a surface course layer in which the leveling course layer and/or the surface course layer include a recycled HMA sheet mix composition.

Abstract: A pavement composition includes a recycled hot mix asphalt (HMA) sheet mix composition including more than 50% and up to 100% recycled fines mixed with a rejuvenating agent. The recycled fines of the HMA sheet mix are separated from a reclaimed asphalt pavement (RAP) composition and substantially all of the recycled fines are capable of passing through a sieve having an opening size of ? inch (9.5 mm). Pavement systems include an existing pavement layer and a thin-lift overlay made of the recycled HMA sheet mix on the existing pavement layer. Pavement systems also include a three-layer system including a leveling course layer, an interlayer, and a surface course layer in which the leveling course layer and/or the surface course layer include a recycled HMA sheet mix composition.

Abstract: A pavement composition includes a recycled hot mix asphalt (HMA) sheet mix composition including more than 50% and up to 100% recycled fines mixed with a rejuvenating agent. The recycled fines of the HMA sheet mix are separated from a reclaimed asphalt pavement (RAP) composition and substantially all of the recycled fines are capable of passing through a sieve having an opening size of ? inch (9.5 mm). Pavement systems include an existing pavement layer and a thin-lift overlay made of the recycled HMA sheet mix on the existing pavement layer. Pavement systems also include a three-layer system including a leveling course layer, an interlayer, and a surface course layer in which the leveling course layer and/or the surface course layer include a recycled HMA sheet mix composition.

Abstract: A pavement composition includes a recycled hot mix asphalt (HMA) sheet mix composition including more than 50% and up to 100% recycled fines mixed with a rejuvenating agent. The recycled fines of the HMA sheet mix are separated from a reclaimed asphalt pavement (RAP) composition and substantially all of the recycled fines are capable of passing through a sieve having an opening size of ? inch (9.5 mm). Pavement systems include an existing pavement layer and a thin-lift overlay made of the recycled HMA sheet mix on the existing pavement layer. Pavement systems also include a three-layer system including a leveling course layer, an interlayer, and a surface course layer in which the leveling course layer and/or the surface course layer include a recycled HMA sheet mix composition.

Abstract: A method, processing system and computer readable medium are disclosed for modifying a form. In one particular aspect, the method includes the a processing system performing the following steps: transferring form data indicative of at least part of a form to a plurality of user devices; receiving, from the plurality of user devices, user interaction data indicative of user interaction with at least part of the form; analyzing the user interaction data to determine a user effort metric in relation to user interaction with at least part of the form; and outputting, based on the user effort metric, one or more recommended modifications to the form.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: Disclosed is a computer implemented data collection method and system. In one aspect the method includes: transferring a message indicative of a form question of a form via a communication service for presentation in a conversational format upon a data entry processing system; receiving, via the communication service, a response in a conversational format from the user operating the data entry processing system; attempting to interpret the response using an expert system; in the event that the response data is interpreted as an answer, recording the answer as part of form instance data; and in the event that the response cannot be interpreted by the expert system, facilitating a data collection user to conduct a portion of the data collection session via the data collection processing system, wherein input is subsequently received from the data collection user to continue interpreting further responses during the form collection session.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: Embodiments of the present invention are directed to compositions and methods for a thermoplastic paving composition including an asphalt rubber binder and a polyethylene polymer additive.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: A method, processing system and computer readable medium are disclosed for modifying a form. In one particular aspect, the method includes the a processing system performing the following steps: transferring form data indicative of at least part of a form to a plurality of user devices; receiving, from the plurality of user devices, user interaction data indicative of user interaction with at least part of the form; analyzing the user interaction data to determine a user effort metric in relation to user interaction with at least part of the form; and outputting, based on the user effort metric, one or more recommended modifications to the form.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.

Abstract: Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.

Abstract: In one embodiment, a system for attaching a prosthetic limb to a user's lower torso includes a socket shaped to receive therein a leg amputation site of the user. The system also includes a flexible garment assembly configured to be worn around the user's waist. The system additionally includes an anchor coupled to the flexible garment assembly at a plurality of attachment points, the anchor having a higher rigidity than the flexible garment assembly. The system additionally includes a first strap secured to the anchor and configured to selectively couple the socket to the flexible garment assembly via the anchor wherein the anchor is configured to transfer to a distributed area of the flexible garment assembly a force applied to the anchor by the socket.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract: Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.