Abstract: Phenylsulfonamido compounds that inhibit genome-wide hypomethylation and can be used to treat cancer, including melanoma, prostate cancer, pancreatic cancer, breast cancer, colon cancer, lung cancer, ovarian cancer, and glioblastoma, are provided.

Abstract: A method for configuring a system having a wearable optical unit is disclosed. The method includes powering on the system, and in response to the system being powered on, using one or more processors to control the system to: determine whether to cause the system to run a configuration workflow, and in response to determining to cause the system to run the configuration workflow, (a) control the system in connection with configuring an interpupillary distance (IPD) for a user of the system, (b) determine whether the IPD is configured for the user, and (c) in response to determining that the IPD is configured for the user, control the system in connection with configuring a focus of the optical unit.

Abstract: The present application discloses a system and device for displaying content. The system includes two optical units. The two optical units are part of the system that is wearable. Each of the two optical units comprises a front lit display. The system includes an adjustable mounting. The adjustable mounting enables a user to adjust a mounting position of the two optical units.

Abstract: Provided herein are compositions that include proteins that include a mitochondrial localization amino acid sequence attached to a base editor fusion protein including a nucleotide base-modifying enzyme and an RNA-guided DNA endonuclease enzyme with modified endonuclease activity. Provided herein are nucleic acids encoding the proteins and vectors including the nucleic acids. Provided herein are pharmaceutical compositions including the compositions, proteins, nucleic acid and vectors. Provided herein are related methods for modifying mitochondrial DNA and treating mitochondrial disorders.

Abstract: A wheel hub assembly for a bicycle is disclosed. The wheel hub assembly may comprise a hub shell for a wheel and coupled to a hub body with an axle by a ratchet mechanism and configured to provide an engaged state where the hub body/axle and the hub shell/wheel rotate together and a disengaged state where the hub body/axle may rotate independently relative to hub shell/wheel; the ratchet mechanism may comprise a set of ratchet rings configured with a set of teeth and sets/groups of pawls configured to engage/disengage the teeth of a ratchet ring; ratchet rings may be configured/installed in the hub body in an aligned condition or an offset condition; when ratchet rings are configured in an offset condition the ratchet mechanism may be configured to facilitate a generally more responsive transition between the disengaged state and the engaged state for the hub body/axle and hub shell/wheel.

Abstract: A wheel hub assembly for a bicycle is disclosed. The wheel hub assembly may comprise a hub shell for a wheel and coupled to a hub body with an axle by a ratchet mechanism and configured to provide an engaged state where the hub body/axle and the hub shell/wheel rotate together and a disengaged state where the hub body/axle may rotate independently relative to hub shell/wheel; the ratchet mechanism may comprise a set of ratchet rings configured with a set of teeth and sets/groups of pawls configured to engage/disengage the teeth of a ratchet ring; ratchet rings may be configured/installed in the hub body in an aligned condition or an offset condition; when ratchet rings are configured in an offset condition the ratchet mechanism may be configured to facilitate a generally more responsive transition between the disengaged state and the engaged state for the hub body/axle and hub shell/wheel.