Patents by Inventor John Craig Smith

John Craig Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRas G12D inhibitors
    Patent number: 11964989
    Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: April 23, 2024
    Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.
    Inventors: Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson, Matthew Arnold Marx, Christopher Ronald Smith, Shelley Allen, James F. Blake, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Macedonio J. Mejia, Brad Newhouse, Phong Nguyen, Jacob Matthew O'Leary, Spencer Pajk, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P.A. Vigers, Qian Zhao, Dean Russell Kahn, John Gaudino, Michael Christopher Hilton
  • Chemical compounds
    Publication number: 20030129596
    Abstract: This invention relates to polymorphisms in the human KDR gene and corresponding novel allelic polypeptides encoded thereby. In particular, the invention relates to two polymorphisms in the coding sequence of the KDR gene, each of which lead to an amino acid change in the sequence of expressed protein; three single nucleotide polymorphisms (SNPs) in the promoter region; one SNP in the 5′ UTR and seven SNPs in intronic sequence. The invention also relates to methods and materials for analysing allelic variation in the KDR gene, and to the use of KDR polymorphism in treatment of KDR ligand (Vascular Endothelial Growth Factor VEGF)-mediated diseases such as cancer and various inflammatory diseases.
    Type: Application
    Filed: November 2, 2001
    Publication date: July 10, 2003
    Inventor: John Craig Smith
  • Diagnostic method
    Publication number: 20020160362
    Abstract: This invention relates to single nucleotide polymorphisms in the human urokinase plasminogen activator receptor (uPAR) gene and corresponding novel allelic polypeptides encoded thereby. The invention also relates to methods and materials for analysing allelic variation in the uPAR gene and to the use of said polymorphism in the diagnosis and treatment of uPAR ligand mediated diseases, such as cancer or arthritis.
    Type: Application
    Filed: February 2, 2001
    Publication date: October 31, 2002
    Inventor: John Craig Smith
  • Yeast artificial chromosomes containing DNA encoding the cystic fibrosis (CFTR) gene
    Patent number: 5939255
    Abstract: Yeast Artificial Chromosomes (YACS) containing DNA encoding the cystic fibrosis (CFTR) gene are described. The YACs allow detailed analysis of the coding and non-coding regions of the gene and the determination of cystic fibrosis alleles in sample DNA from an individual or individuals.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 17, 1999
    Assignee: Zeneca Limited
    Inventors: Rakesh Anand, Alexander Fred Markham, John Craig Smith, Rashida Anwar, John Hamilton Riley, Donald James Ogilvie, Paul Elvin