Abstract: In various aspects and embodiments, the present invention provides abuse deterrent pharmaceutical formulations, and methods of making the same. The abuse deterrent formulations can comprise a CNS stimulant (particularly one that is addictive or prone to be abused) and an opioid receptor antagonist. These agents are bound by one or more pharmaceutically acceptable resins (e.g., ion exchange resins) to limit their potential to be separated by a potential abuser.

Abstract: The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.

Abstract: A scene may be rendered as objects that are lit by various light sources. A scene designer may arrange the scene to create particular lighting effects when viewed from an initial perspective, such as gloss, translucency, and iridescence, and may choose lighting effects to create a desired aesthetic tone and/or highlighting within the scene. However, rendering the scene from a different perspective may alter the lighting effects (e.g., losing or misplacing desired lighting effects, and/or creating new and undesirable lighting effects, such as glare). Instead, when the scene is rendered from the initial perspective, the lighting effects created therein may be stored with the scene representation of the scene. A second rendering of the scene from a different perspective may reapply the stored lighting effects to the lit objects, thereby maintaining the lighting effects and the intent of the designer in the presentation of the scene from a different perspective.

Abstract: The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.

Abstract: The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.

Abstract: The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.

Abstract: A scene may be rendered as objects that are lit by various light sources. A scene designer may arrange the scene to create particular lighting effects when viewed from an initial perspective, such as gloss, translucency, and iridescence, and may choose lighting effects to create a desired aesthetic tone and/or highlighting within the scene. However, rendering the scene from a different perspective may alter the lighting effects (e.g., losing or misplacing desired lighting effects, and/or creating new and undesirable lighting effects, such as glare). Instead, when the scene is rendered from the initial perspective, the lighting effects created therein may be stored with the scene representation of the scene. A second rendering of the scene from a different perspective may reapply the stored lighting effects to the lit objects, thereby maintaining the lighting effects and the intent of the designer in the presentation of the scene from a different perspective.

Abstract: An on-chip micro-fluidic device (10) fabricated using a semiconductor material. The device has a micro-fluidic channel or chamber (14) defined within the material and one or more monolithically integrated semiconductor lasers (12) operate to form an optical trap in the channel or chamber (14).