Patents by Inventor John Crary

John Crary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Micrornas that silence tau expression
    Patent number: 9951330
    Abstract: This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with abnormal tau expression, e.g., tauopathies, using the 3?untranslated region (UTR) of the tau messenger RNA (mRNA) as a target, specifically using microRNAs that regulate the expression of tau. This invention is also in the field of screening for, identifying, and diagnosing such diseases. Specifically, this invention provides biomarkers for these diseases in the form of microRNAs.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 24, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: John Crary, Ismael Santa-Maria Perez
  • MICRORNAS THAT SILENCE TAU EXPRESSION
    Publication number: 20170002348
    Abstract: This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with abnormal tau expression, e.g., tauopathies, using the 3?untranslated region (UTR) of the tau messenger RNA (mRNA) as a target, specifically using microRNAs that regulate the expression of tau. This invention is also in the field of screening for, identifying, and diagnosing such diseases. Specifically, this invention provides biomarkers for these diseases in the form of microRNAs.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 5, 2017
    Inventors: John Crary, Ismael Santa-Maria Perez
  • PLURIPOTENT STEM CELLS DERIVED FROM NON-CRYOPROTECTED FROZEN TISSUE AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20160130561
    Abstract: In some embodiments the present invention provides cells, such as pluripotent stem cells and differentiated cells, derived from tissue samples that have been frozen without a cryoprotective agent, and also cell panels comprising such cells, model systems comprising such cells, and methods for making and using such cells, cell panels, and model systems.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 12, 2016
    Inventors: Andrew Sproul, John Crary, Lauren Ab Vensand, Carmen Dusenberry, Scott Noggle, Michael Shelanski
  • BIOMARKERS FOR CHRONIC TRAUMATIC ENCEPHALOPATHY
    Publication number: 20150337375
    Abstract: This invention relates to the field of screening for, identifying, diagnosing, and prognosing chronic traumatic encephalopathy (CTE). Specifically, this invention provides various biomarkers for this disease, and methods of using these biomarkers to correctly diagnose, prognose and predict those individuals who would develop CTE after suffering from mild traumatic brain injury. The invention also provides targets for drug development and basic research for CTE and preventative and therapeutic agents for CTE.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 26, 2015
    Inventors: John Crary, Ann MCKEE
  • Atypical protein kinase c isoforms in disorders of the nervous system and cancer
    Publication number: 20060185026
    Abstract: The present invention establishes a link between altered aPKC function and nervous system disorders and cancers, such as Alzheimer's disease (AD) and neuroblastoma. Methods of using aPKC in diagnosis, drug screening and gene therapy in nervous system disorders and cancers are provided.
    Type: Application
    Filed: November 3, 2003
    Publication date: August 17, 2006
    Inventors: Todd Sacktor, John Crary, Alejandro Hernanadez, Suzanme Mirra, Charles Shao