Abstract: Disclosed are methods and compositions for functional genetic modifications at selected sites. Also provided are cell populations, which comprise targeted integration of one or more exogenous polynucleotides, and/or indels at one or more selected gene loci.

Abstract: The disclosure provides improved Cas-CLOVER systems for gene editing. In embodiments, the disclosure provides recombinant Clo051 endonucleases, or nuclease domains thereof, comprising one or more amino acid mutations (e.g. one or more amino acid substitutions at E101 and/or F44). The disclosure also provides fusion proteins, comprising: a DNA localization component, and any one of the Clo051 endonucleases disclosed herein or the nuclease domains thereof, and further provides methods of using the fusions proteins in gene editing, including introducing a double stranded break in a target nucleic acid.

Abstract: Provided herein are methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, for example, in the treatment of a mental health disorder or chronic inflammatory disease.

Abstract: A pocket knife includes a chassis and an insert engaged with the chassis, wherein the insert defines an insert surface. A blade has a retracted position in which the blade is inside of the chassis and a deployed position in which at least a portion of the blade is outside of the chassis. An actuator is slidingly engaged with the chassis to reposition the blade between the retracted and deployed positions. A lock is pivotally connected to the chassis and engaged with the blade in the deployed position to lock the blade in the deployed position. A stop pin is connected to the blade, and an end of the stop pin extends a predetermined distance from the blade to engage with the insert surface when the blade is in the deployed position to prevent movement of the blade with respect to the chassis.

Abstract: Disclosed herein are methods, systems, and devices for reducing user effort for sensor provisioning. In one embodiment, a system includes one or more processors and one or more memories including program instructions. The program instructions when executed are configured for receiving and storing initial sensor provisioning instructions from a graphical user interface (GUI) and provisioning a first plurality of sensors using the initial sensor provisioning instructions.

Abstract: Disclosed herein are methods, systems, and devices for reducing user effort for sensor provisioning. In one embodiment, a system includes one or more processors and one or more memories including program instructions. The program instructions when executed are configured for receiving and storing initial sensor provisioning instructions from a graphical user interface (GUI) and provisioning a first plurality of sensors using the initial sensor provisioning instructions.

Abstract: Provided herein are methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, for example, in the treatment of a mental health disorder or chronic inflammatory disease.

Abstract: A folding knife includes first and second scales and a blade having a tang and a cutting edge. The tang pivotally connects the blade between the first and second scales. The blade has a retracted position with the cutting edge between the first and second scales and a deployed position with the cutting edge outside the first and second scales. An actuator between the first and second scales has a first position that locks the blade in the deployed position and a second position that allows movement of the blade between the deployed and retracted positions. A spring is in compression with the actuator between the first and second scales so that the spring biases the actuator toward the tang of the blade. A detent in the actuator engages with the tang when the actuator is in the first position and the blade is in the deployed position.

Abstract: Provided herein are methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, for example, in the treatment of a mental health disorder or chronic inflammatory disease.

Abstract: A folding knife includes a handle, a first liner inside the handle, and a second liner inside the handle and opposed to the first liner. A blade has a tang and a cutting edge, and the tang of the blade pivotally connects the blade between the first and second liners. The blade has a retracted position in which the cutting edge is inside the handle and a deployed position in which the cutting edge is outside the handle. An actuator is at least partially between the first and second liners, and a spring is between the first and second liners and in compression against the actuator so that the spring biases the actuator toward the tang of the blade.

Abstract: Provided herein are methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, for example, in the treatment of a mental health disorder or chronic inflammatory disease.

Abstract: Disclosed herein are methods, systems, and devices for reducing user effort for sensor provisioning. In one embodiment, a system includes one or more processors and one or more memories including program instructions. The program instructions when executed are configured for receiving and storing initial sensor provisioning instructions from a graphical user interface (GUI) and provisioning a first plurality of sensors using the initial sensor provisioning instructions.