Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. In one example, the system comprises a container for holding the therapeutic agent, and a pressure source having pressurized fluid, wherein the pressure source is in selective fluid communication with at least a portion of the container. A catheter is placed in fluid communication with the container, and has a lumen sized for delivery of the therapeutic agent to a target site. A housing is configured to securely retain the container. The system further comprises a camera having a camera head coupled to the catheter, wherein the camera provides a visual image of the target site during delivery of the therapeutic agent.

Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. In one example, the system comprises a container for holding the therapeutic agent, and a pressure source having pressurized fluid, wherein the pressure source is in selective fluid communication with at least a portion of the container. A catheter is placed in fluid communication with the container, and has a lumen sized for delivery of the therapeutic agent to a target site. A housing is configured to securely retain the container. The system further comprises a camera having a camera head coupled to the catheter, wherein the camera provides a visual image of the target site during delivery of the therapeutic agent.

Abstract: An endoscopic device is provided. The endoscopic device may comprise a distal end and a proximal end. The proximal end may be opposite the distal end. The endoscopic device may further comprise a handle at the proximal end and a tube extending from the handle towards the distal end of the endoscopic device. The endoscopic device may further comprise an accessory channel. The accessory channel may extend through the tube. The endoscopic device may further comprise a slide, the accessory channel connected to the slide, and a track disposed adjacent to the proximal end of the endoscopic device. The slide is movable within the track to cause movement of the accessory channel within the tube.

Abstract: The present invention relates to a long-lasting medical product for protecting or treating a lesion in the gastrointestinal tract. The medical product includes a protective covering, wherein the medical product upon application at and about the site of the lesion adheres to the gastrointestinal tissue and is capable of remaining at and about the site of the lesion for a time sufficient to allow the lesion to heal or be treated.

Abstract: A bipolar sphincterotome may include an elongate tubular member longitudinally extending from a proximal portion to a distal portion, an active path comprising a cutting edge exposed outside of the elongate tubular member, and a return electrode disposed over an outer surface of the elongate tubular member. In various embodiments, in an axial cross-section of the bipolar sphincterotome, the return electrode does not intersect a transverse axis. In addition or alternatively, a minimum distance between the cutting edge and the return electrode is at least about 0.050 inches.

Abstract: A bipolar sphincterotome may include an elongate tubular member, a cutting wire, and a return path. The return path may include a conductive ink portion disposed on an outer surface at a distal portion of the tubular member. The return path may also include a return wire disposed within the tubular member that is electrically coupled to the conductive ink portion. In some example embodiments, the return wire may be disposed within a lumen configured to have two or more functions, one of which being to house the return wire. Additionally, in some example embodiments, the conductive ink portion may be circumferentially disposed on the outer surface to provide visual access to a wire guide lumen. Also, for some example embodiments, the bipolar sphincterotome may include two electrically isolated return paths.

Abstract: Endoscope systems with bending sections that can bend in four directions independent of the rotatable viewing configuration of the endoscope systems are provided. Embodiments include continuous and uncontinuous ribs that provide for at least one accessory channel structure to be movable laterally into and out of a longitudinal interior cavity circumferentially defined by the ribs. Methods of using the endoscope systems in a patient's body are further provided.

Abstract: A bipolar sphincterotome may include an elongate tubular member, a cutting wire, and a return path. The return path may include a conductive ink portion disposed on an outer surface at a distal portion of the tubular member. The return path may also include a return wire disposed within the tubular member that is electrically coupled to the conductive ink portion. In some example embodiments, the return wire may be disposed within a lumen configured to have two or more functions, one of which being to house the return wire. Additionally, in some example embodiments, the conductive ink portion may be circumferentially disposed on the outer surface to provide visual access to a wire guide lumen. Also, for some example embodiments, the bipolar sphincterotome may include two electrically isolated return paths.

Abstract: A bipolar sphincterotome may include an elongate tubular member, a cutting wire, and a return path. The return path may include a conductive ink portion disposed on an outer surface at a distal portion of the tubular member. The return path may also include a return wire disposed within the tubular member that is electrically coupled to the conductive ink portion. In some example embodiments, the return wire may be disposed within a lumen configured to have two or more functions, one of which being to house the return wire. Additionally, in some example embodiments, the conductive ink portion may be circumferentially disposed on the outer surface to provide visual access to a wire guide lumen. Also, for some example embodiments, the bipolar sphincterotome may include two electrically isolated return paths.

Abstract: Endoscope systems with bending sections that can bend in four directions independent of the rotatable viewing configuration of the endoscope systems are provided. Methods of using the endoscope systems in a patient's body are further provided.

Abstract: An endoscopic device is provided. The endoscopic device may comprise a distal end and a proximal end. The proximal end may be opposite the distal end. The endoscopic device may further comprise a handle at the proximal end and a tube extending from the handle towards the distal end of the endoscopic device. The endoscopic device may further comprise an accessory channel. The accessory channel may extend through the tube. The endoscopic device may further comprise a slide, the accessory channel extending through the slide, and a curved track disposed adjacent to the proximal end of the endoscopic device. The slide is movable within the curved track to cause movement of the accessory channel within the tube.

Abstract: An expandable dilation member may include a proximally-tapered portion to dilate a stricture. The dilation member may be distally advanced in an unexpanded state over a wire guide through the stricture. The dilation member may then be configured in an expanded state, where the dilation member has a longitudinal profile that includes the proximally-tapered portion. A handle assembly proximally pulls the dilation member in the expanded state. In response, the proximally-tapered portion engages with and biases the stricture. When biasing the stricture, the proximally-tapered portion exerts a plurality of different types of forces, including a shearing force, a radial force, and in some procedures, a torsional force. In some embodiments, the proximally-tapered portion has a continuous taper from a smallest diameter to a largest diameter. In other embodiments, the proximally-tapered portion has at least one constant-diameter portion longitudinally disposed in between the smallest diameter and the largest diameter.

Abstract: The present embodiments provide systems and methods suitable for delivering an agent including a plurality of particles to a target site. In example embodiments, a system suitable for delivering an agent to a target site includes a catheter having a first wall defining a lumen sized for delivery of the agent to the target site. The catheter has a distal end terminating with a primary opening of the lumen, an opposing proximal end, and a longitudinal axis extending between the distal end and the proximal end. At least one secondary opening is formed at the distal end, wherein the secondary opening is configured to allow fluid to flow through the secondary opening to create a steady flow of fluid at an angle with respect to the longitudinal axis and prevent the plurality of particles from flowing through the secondary opening.

Abstract: Endoscope systems with bending sections that can bend in four directions independent of the rotatable viewing configuration of the endoscope systems are provided. Methods of using the endoscope systems in a patient's body are further provided.

Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. In one example, the system comprises a container for holding the therapeutic agent, and a pressure source having pressurized fluid, wherein the pressure source is in selective fluid communication with at least a portion of the container. A catheter is placed in fluid communication with the container, and has a lumen sized for delivery of the therapeutic agent to a target site. A housing is configured to securely retain the container. The system further comprises a camera having a camera head coupled to the catheter, wherein the camera provides a visual image of the target site during delivery of the therapeutic agent.

Abstract: A tissue-collection stylet is configured with inward-facing barbs, for use in a needle, and particularly configured to capture intact tissue cores suitable for histological analysis. The stylet may be provided together with a needle as part of a biopsy system in which the stylet remains at least partially or fully within a lumen of the needle during collection of tissue samples and/or other samples.

Abstract: An expandable dilation member may include a proximally-tapered portion to dilate a stricture. The dilation member may be distally advanced in an unexpanded state over a wire guide through the stricture. The dilation member may then be configured in an expanded state, where the dilation member has a longitudinal profile that includes the proximally-tapered portion. A handle assembly proximally pulls the dilation member in the expanded state. In response, the proximally-tapered portion engages with and biases the stricture. When biasing the stricture, the proximally-tapered portion exerts a plurality of different types of forces, including a shearing force, a radial force, and in some procedures, a torsional force. In some embodiments, the proximally-tapered portion has a continuous taper from a smallest diameter to a largest diameter. In other embodiments, the proximally-tapered portion has at least one constant-diameter portion longitudinally disposed in between the smallest diameter and the largest diameter.

Abstract: The present embodiments provide a system for facilitating closure of a bodily opening. In one embodiment, the system comprises an anchor having a deployed state dimensioned for engaging tissue surrounding the opening, a first tether coupled to the anchor and extending proximally therefrom, and a graft member comprising a first bore disposed therein. The anchor may comprise a width that is larger than a width of the opening such that the anchor is disposed securely within or distal to the opening. The first tether is dimensioned to be disposed through the first bore in the graft member, such that the graft member is advanced distally over the first tether. The graft member then may be secured to the anchor. Various anchor designs are provided along with a supporting framework that may be coupled to the graft member.

Abstract: The present embodiments provide systems and methods suitable for delivering an agent including a plurality of particles to a target site. In example embodiments, a system suitable for delivering an agent to a target site includes a catheter having a first wall defining a lumen sized for delivery of the agent to the target site. The catheter has a distal end terminating with a primary opening of the lumen, an opposing proximal end, and a longitudinal axis extending between the distal end and the proximal end. At least one secondary opening is formed at the distal end, wherein the secondary opening is configured to allow fluid to flow through the secondary opening to create a steady flow of fluid at an angle with respect to the longitudinal axis and prevent the plurality of particles from flowing through the secondary opening.

Abstract: An electrosurgical medical device may include an elongate needle that is delivered to a gastrointestinal tract of a patient and inserted through the gastrointestinal wall and into a cyst. Fluid within the cyst may be aspirated through a lumen of the needle. The cyst may then be filled with conductive fluid by delivering the conductive fluid through the needle lumen. Radio frequency energy may then be delivered to the needle and transferred to the cyst to ablate the cyst. A handle assembly of the electrosurgical medical device may communicate the cyst and conductive fluids to and from the needle lumen, as well as communicate radio frequency energy to the needle and a temperature signal generated by a thermocouple. An electrical cable assembly adapted to communicate both the radio frequency energy and the temperature signal may be removably connectable with the handle assembly.