Patents by Inventor John CROWN

John CROWN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A METHOD OF PREDICTING RESPONSE TO TREATMENT IN CANCER PATIENTS
    Publication number: 20220221459
    Abstract: A method of predicting response to chemotherapy in a patient with cancer is described. The method comprises the steps of incubating an ADCC-capable molecule, an immune response modulator, a cancer cell line that expresses a target of the ADCC-capable molecule, and a sample of the patient's blood, for a period of time, determining an ADCC response of the cancer cell line, comparing the ADCC response with a reference ADCC response, and predicting the patient's response to chemotherapy based on the comparison. In one aspect, the cancer is a HER2+ cancer, the ADCC-capable molecule is an antibody targeting HER2, and the cancer cell lines is a HER2+ cancer cell line.
    Type: Application
    Filed: July 9, 2019
    Publication date: July 14, 2022
    Applicant: DUBLIN CITY UNIVERSITY
    Inventors: Denis COLLINS, Nicola GAYNOR, John CROWN, Norma O'DONOVAN