Patents by Inventor John Cuozzo

John Cuozzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT TRANSFER VECTORS FOR PROTEIN EXPRESSION IN INSECT AND MAMMALIAN CELLS
    Publication number: 20220251600
    Abstract: Described herein are recombinant vectors and methods for their use in expressing recombinant proteins in both insect and mammalian cells. The invention is based on recombinant transfer vectors that enable expression of one or more transgenes to be directed by an insect cell-competent promoter and a mammalian cell-competent promoter, both present within a single expression cassette in the vector, and active conditional on the host cell.
    Type: Application
    Filed: June 25, 2020
    Publication date: August 11, 2022
    Inventors: Alexander LITOVCHICK, Ragunath CHANDRAN, Moritz VON RECHENBERG, John CUOZZO
  • METHODS FOR TAGGING DNA-ENCODED LIBRARIES
    Publication number: 20210002630
    Abstract: The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2?-substituted nucleotides, such as 2?-O-methyl or 2?-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
    Type: Application
    Filed: May 7, 2020
    Publication date: January 7, 2021
    Inventors: Anthony D. KEEFE, Richard W. WAGNER, Alexander LITOVCHICK, Matthew CLARK, John CUOZZO, Ying ZHANG, Paolo A. CENTRELLA, Christopher D. HUPP
  • Benzhydrol-pyrazole derivatives having kinase inhibitory activity and uses thereof
    Patent number: 9394256
    Abstract: The present invention features benzhydrol-pyrazole derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: July 19, 2016
    Assignee: X-Chem, Inc.
    Inventors: Anthony D. Keefe, Richard W. Wagner, Matthew Clark, Ying Zhang, Diana Gikunju, John Cuozzo, Heather Thomson
  • Tryptoline derivatives having kinase inhibitory activity and uses thereof
    Patent number: 9394296
    Abstract: The present invention features tryptoline derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: July 19, 2016
    Assignee: X-Chem, Inc.
    Inventors: Anthony D. Keefe, Richard W. Wagner, Matthew Clark, Ying Zhang, Diana Gikunju, John Cuozzo, Heather Thomson
  • BENZHYDROL-PYRAZOLE DERIVATIVES HAVING KINASE INHIBITORY ACTIVITY AND USES THEREOF
    Publication number: 20150005345
    Abstract: The present invention features benzhydrol-pyrazole derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 1, 2015
    Inventors: Anthony D. Keefe, Richard W. Wagner, Matthew Clark, Ying Zhang, Diana Gikunju, John Cuozzo, Heather Thomson
  • TRYPTOLINE DERIVATIVES HAVING KINASE INHIBITORY ACTIVITY AND USES THEREOF
    Publication number: 20150005310
    Abstract: The present invention features tryptoline derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 1, 2015
    Applicant: X-Rx, Inc
    Inventors: Anthony D. Keefe, Richard W. Wagner, Matthew Clark, Ying Zhang, Diana Gikunju, John Cuozzo, Heather Thomson
  • APPARATUS AND METHOD FOR PAIN CONTROL THROUGH NERVE STIMULATION BY AN INTRA-ORAL SOURCE
    Publication number: 20080027506
    Abstract: A method of pain control via the nervous system of a mammal includes contacting an oral tissue of a mammal with an energy source and imparting energy to the oral tissue to reduce perception of a pain response from the central or peripheral nervous system of the mammal.
    Type: Application
    Filed: July 27, 2007
    Publication date: January 31, 2008
    Inventor: John Cuozzo
  • 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same
    Publication number: 20060276498
    Abstract: The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
    Type: Application
    Filed: May 18, 2006
    Publication date: December 7, 2006
    Applicant: Wyeth
    Inventors: Neal Green, Lori Gavrin, Neelu Kaila, Yonghan Hu, Kristin Janz, Jennifer Thomason, Ariamala Gopalsamy, Steve Tam, Lih-Ling Lin, John Cuozzo, Dennis Powell
  • 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same
    Publication number: 20060264460
    Abstract: The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
    Type: Application
    Filed: May 18, 2006
    Publication date: November 23, 2006
    Applicant: Wyeth
    Inventors: Neal Green, Yonghan Hu, Neelu Kaila, Kristin Janz, Jennifer Thomason, Huan-Qiu Li, Rajeev Hotchandani, Junjun Wu, Ariamala Gopalsamy, Steve Tam, Lih-Ling Lin, John Cuozzo, Satenig Guler, Adrian Huang, Jeffrey condon