Abstract: The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.

Abstract: The invention relates to a conjugate PT comprising (a) a peptide P and (b) a targeting moiety T; wherein the peptide P contains from 4 to 20 amino acid residues with optionally a single thiol moiety at the C— or N-terminus replacing one of these amino acid residues, and including a complexing amino acid sequence comprising (iv) a tridentate or tetradentate planar chelator containing a ligand backbone defined by a perimeter containing a single sulfur donor atom, two or three non-sulfur donor atoms, and intervening atoms between the donor atoms; and (v) a stabilizing sidechain comprising a further donor atom, the further donor atom being covalently linked to the ligand backbone of the planar chelator through two or three intervening atoms, provided that said further donor atom is neither the nitrogen nor the oxgen atom of a peptide bond and if said further donor atom is part of a heterocyclic ring, no more than one of the intervening atoms can be part of that ring; and a radioactive metal complexed to the donor

Abstract: Surgical methods of and kits for applying and stabilizing a mass of fibrin sealant or platelet concentrate at the site of surgical attachment of an implantable medical device to effect hemostasis to stem internal bleeding at the site of surgical attachment are disclosed. A mass of fibrin sealant or platelet concentrate is applied onto a porous fabric, whereby the mass is supported in the interstices or pores of the fabric, and the supported mass is applied against the site of high pressure blood leakage. The supported mass achieves hemostasis as it does not wash away from the site. The present invention is particularly useful to effect hemostasis at sutures and suture holes extending through thin-walled tissue valves and grafts when such tissue valves or grafts are sutured in place, particularly at high blood pressure sites as at the valve annulus of the aortic valve or the aorta.

Abstract: A method of alleviating the symptoms of rhabdomyolysis or the side effects of statin DRUG administration is disclosed. The method comprises the administration of D-ribose in doses of three to ten grams at least twice a day until the symptoms or side effects are alleviated.

Abstract: A switch fabric includes a first plurality of data switches each having a plurality of input ports and a plurality of output ports the plurality of switches capable of switching any of its input ports to any of its output ports with the plurality of data switches having inputs coupled to a plurality of input buses so that a first byte of a first one of the input buses is coupled to a first one of the plurality of switches, and a succeeding byte of the first input bus is coupled to a succeeding one of the plurality of switches.

Abstract: Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.

Abstract: Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.

Abstract: A switch fabric includes a first plurality of data switches each having a plurality of input ports and a plurality of output ports the plurality of switches capable of switching any of its input ports to any of its output ports with the plurality of data switches having inputs coupled to a plurality of input buses so that a first byte of a first one of the input buses is coupled to a first one of the plurality of switches, and a succeeding byte of the first input bus is coupled to a succeeding one of the plurality of switches.

Abstract: A switch fabric includes a first plurality of data switches each having a plurality of input ports and a plurality of output ports the plurality of switches capable of switching any of its input ports to any of its output ports with the plurality of data switches having inputs coupled to a plurality of input buses so that a first byte of a first one of the input buses is coupled to a first one of the plurality of switches, and a succeeding byte of the first input bus is coupled to a succeeding one of the plurality of switches.

Abstract: A packet processing system or router is disclosed that has at least one central packet-header processor, a packet broadcast bus, and local packet controllers that communicate with each other and the central packet-header processor via the packet broadcast bus. Packets received by media access controllers are passed to the associated local packet controllers and then broadcast on the packet broadcast bus. These broadcast packets are stored in packet buffer memories of the controllers, and the processor snoops for at least headers of the broadcast packets. The headers are analyzed and the processor issues forwarding instructions concerning the broadcast packets to the local packet controllers. As a result, the packet data only traverses the bus once. Only a relatively short forwarding decision is generated after the packets are broadcast and this can occur on a separate control bus, if desired.