Patents by Inventor John D. Baxter

John D. Baxter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microbiological synthesis of beta endorphin
    Patent number: 4350764
    Abstract: DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of .beta.-lipotropin and including the entire coding region for .beta.-endorphin with the exception of the C-terminal glutamine was modified, transferred to an expression transfer vector, and expressed as a fusion protein. The fusion protein was further modified in vitro to yield mature .beta.-endorphin. .beta.-endorphin was purified from a bacterial lysate. The structure and biological activity of the resulting product was proven by immunological assay, and by two independent assays designed to demonstrate biological activity.
    Type: Grant
    Filed: March 10, 1980
    Date of Patent: September 21, 1982
    Assignee: The Regents of the University of California
    Inventors: John D. Baxter, Ivy Fettes, John Shine
  • Adrenocorticotropin-lipotropin precursor gene
    Patent number: 4322499
    Abstract: A technique suitable for cloning a cDNA having a base sequence coding for the ACTH/LPH precursor is disclosed. The invention is exemplified by the cloning of a cDNA fragment comprising a base sequence coding for the endorphin region. The fragment, hereinafter termed the endorphin gene cDNA sequence, was obtained from cultured mouse pituitary tumor cells known to produce the ACTH/LPH precursor protein.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: March 30, 1982
    Assignee: The Regents of the University of California
    Inventors: John D. Baxter, James L. Roberts, Peter H. Seeburg, Howard M. Goodman, John Shine