Patents by Inventor John D. Bradley

John D. Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10233462
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: March 19, 2019
    Assignee: Monsanto Technology LLC
    Inventors: John D. Bradley, Brandi J. Chiapelli, Bingli Gao, James P. McCarter, Michelle L. Gasper, Deryck Jeremy Williams
  • Patent number: 9790516
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Pratylenchus (root lesion nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets are conserved and expected to be essential and sensitive to RNAi perturbation in different Pratylenchus species, facilitating genus-wide targeting by RNA interference.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: October 17, 2017
    Assignee: Monsanto Technology LLC
    Inventors: Brandi Chiapelli, Matt W. Dimmic, Deryck Jeremy Williams, Jennifer Sheppard, John D. Bradley, Carl Diehl, Michelle L. Gasper, Bingli Gao, James P. McCarter
  • Publication number: 20170247718
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
    Type: Application
    Filed: March 7, 2017
    Publication date: August 31, 2017
    Inventors: John D. Bradley, Brandi J. Chiapelli, Bingli Gao, James P. McCarter, Michelle L. Gasper, Deryck Jeremy Williams
  • Patent number: 9624508
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: April 18, 2017
    Assignee: Monsanto Technology LLC
    Inventors: John D. Bradley, Brandi J. Chiapelli, Bingli Gao, James P. McCarter, Michelle L. Gasper, Deryck Jeremy Williams
  • Publication number: 20150203866
    Abstract: The present invention is directed to controlling nematode infestation. The invention discloses methods and compositions for use in controlling nematode infestation by providing recombinant DNA molecules to the cells of a plant in order to achieve a reduction in nematode infestation. The invention is also directed to methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from nematode infestation.
    Type: Application
    Filed: March 9, 2015
    Publication date: July 23, 2015
    Inventors: John D. Bradley, Catherine C. Baublite, Michael J. Crawford, Stanislaw Flasinski, Deryck J. Williams
  • Publication number: 20150135363
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Pratylenchus (root lesion nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets are conserved and expected to be essential and sensitive to RNAi perturbation in different Pratylenchus species, facilitating genus-wide targeting by RNA interference.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 14, 2015
    Inventors: Brandi Chiapelli, Matt W. Dimmic, Deryck Jeremy Williams, Jennifer Sheppard, John D. Bradley, Carl Diehl, Michelle L. Gasper, Bingli Gao, James P. McCarter
  • Patent number: 9006517
    Abstract: The present invention is directed to controlling nematode infestation. The invention discloses methods and compositions for use in controlling nematode infestation by providing recombinant DNA molecules to the cells of a plant in order to achieve a reduction in nematode infestation. The invention is also directed to methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from nematode infestation.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: April 14, 2015
    Assignee: Monsanto Technology LLC
    Inventors: John D. Bradley, Catherine C. Baublite, Michael J. Crawford, Stanislaw Flasinski, Deryck J. Williams
  • Patent number: 8907162
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Pratylenchus (root lesion nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets are conserved and expected to be essential and sensitive to RNAi perturbation in different Pratylenchus species, facilitating genus-wide targeting by RNA interference.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: December 9, 2014
    Assignee: Monsanto Technology LLC
    Inventors: Brandi Chiapelli, Matt W. Dimmic, Deryck Jeremy Williams, Jennifer Sheppard, John D. Bradley, Carl Diehl, Michelle L. Gasper, Bingli Gao, James P. McCarter
  • Patent number: 8901373
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: December 2, 2014
    Assignee: Monsanto Technology LLC
    Inventors: John D. Bradley, Brandi J. Chiapelli, Bingli Gao, James P. McCarter, Michelle L. Gasper, Deryck Jeremy Williams
  • Publication number: 20130036519
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Pratylenchus (root lesion nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets are conserved and expected to be essential and sensitive to RNAi perturbation in different Pratylenchus species, facilitating genus-wide targeting by RNA interference.
    Type: Application
    Filed: December 29, 2010
    Publication date: February 7, 2013
    Applicant: Monsanto Technology LLC
    Inventors: Brandi Chiapelli, Matt W. Dimmic, Deryck Jeremy Williams, Jennifer Sheppard, John D. Bradley, Carl Diehl, Michelle L. Gasper, Bingli Gao, James P. McCarter
  • Patent number: 8198060
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: June 12, 2012
    Assignee: Divergence, Inc.
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu
  • Publication number: 20120030834
    Abstract: The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
    Type: Application
    Filed: April 10, 2009
    Publication date: February 2, 2012
    Inventors: John D. Bradley, Brandi Chiapelli, Bingli Gao, James P. McCarter, Michelle L. Verbsky, Deryck Jeremy Williams
  • Patent number: 7993894
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: August 9, 2011
    Assignee: Divergence, Inc.
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. DaVila-Aponte, Siqun Xu, Anita M. Frevert
  • Publication number: 20110107446
    Abstract: The present invention is directed to controlling nematode infestation. The invention discloses methods and compositions for use in controlling nematode infestation by providing recombinant DNA molecules to the cells of a plant in order to achieve a reduction in nematode infestation. The invention is also directed to methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from nematode infestation.
    Type: Application
    Filed: February 9, 2009
    Publication date: May 5, 2011
    Inventors: John D. Bradley, Catherine C. Baublite, Michael J. Crawford, Stanislaw Flasinski, Deryck J. Williams
  • Patent number: 7867749
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: January 11, 2011
    Assignee: Divergence, Inc.
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert-Thompson, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu
  • Publication number: 20100248357
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Application
    Filed: January 15, 2009
    Publication date: September 30, 2010
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. DaVila-Aponte, Siqun Xu, Anita M. Frevert
  • Patent number: 7666642
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: February 23, 2010
    Assignee: Divergence, Inc.
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. Davila-Aponte, Siqun Xu, Anita M. Frevert
  • Publication number: 20090318563
    Abstract: Certain ethanolamine analogs and related compounds useful in the control of nematodes that infest plants or the situs of plants are described.
    Type: Application
    Filed: December 23, 2008
    Publication date: December 24, 2009
    Inventors: Michelle Coutu Hresko, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Barry J. Shortt, Ronald E. Worthington
  • Publication number: 20090203127
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as arc vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Application
    Filed: January 15, 2009
    Publication date: August 13, 2009
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. Davila-Aponte, Siqun Xu, Anita M. Frevert
  • Publication number: 20090123986
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Application
    Filed: October 28, 2008
    Publication date: May 14, 2009
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu