Patents by Inventor John D. Buehler

John D. Buehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10336290
    Abstract: A vehicle includes a body portion, an opening defined by the body portion, and an extendable bumper that is positioned in the opening and is moveable with respect to the body portions between an extended position and a retracted position. The extendable bumper includes an inflatable structure that causes movement of the extendable bumper between the retracted position and the extended position in response to inflation and deflation of the inflatable structure.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 2, 2019
    Assignee: Apple Inc.
    Inventors: Juan A. Lazaro, Erik Mikael Fermer, Alice C. Watts, Tommaso P. Rivellini, Christian Schermaier, John Raff, Derek C. Scott, David E. Kingman, Bryce A. Woollard, Samuel G. Fowle, Mark B. Rober, Ibuki Kamei, Donald R. Monroe, Jesse T. Buehler, Paul D. Yeomans
  • Publication number: 20150150819
    Abstract: Compositions containing opioid antagonists are disclosed, particularly alvimopan and its active metabolite in solid dosage forms, where the drug is uniformly distributed, achieves the desired bioavailability, and is stable. Methods of preparing and using the compositions containing opioid antagonists are also disclosed. The results are achieved by a combination of processing techniques and component selection.
    Type: Application
    Filed: February 12, 2015
    Publication date: June 4, 2015
    Inventor: John D. Buehler
  • Publication number: 20140303211
    Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventor: John D. Buehler
  • Publication number: 20140057947
    Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Applicant: Adolor Corporation
    Inventor: John D. BUEHLER
  • Publication number: 20140014611
    Abstract: An improved child-resistant closure for dispensers of liquid medicaments, the closure being of a two-part construction. The closure has an outer cap with a quantity of shoulder lugs and skirt lugs and an inner cap with a quantity of shoulder lugs and flexible beams. The closure has equal quantities of shoulder lugs on the inner and outer caps, equal quantities of skirt lugs and flexible beams, flexible beams having an arcuate underside, shoulder lugs having a depth to prevent hyper-flexion of the flexible beams, and an ideal overlap when the faces of the shoulder lugs are aligned. Additionally, provided are methods for attaching and removing the cap from a pre-existing bottle.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 16, 2014
    Inventors: John D. Buehler, John B. Daly, Kevin A. DiPlacido, Redd J. Harold, David T. Kershner, David A. Manera, Timothy K. Stangle, Russ Granato
  • Patent number: 8598207
    Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: December 3, 2013
    Assignee: Adolor Corporation
    Inventor: John D. Buehler
  • Patent number: 8517997
    Abstract: A dispenser assembly for liquid products is disclosed. Such an assembly may include an elongated barrel, and an elongated plunger having a flexible sealing lip disposed at an end thereof. The sealing lip may have an outer diameter in a relaxed state that is greater than an internal cross-sectional diameter of the barrel. When the plunger and barrel are actuated axially relative to one another, the sealing lip flexes inwardly and provides the sole contact between the plunger and the barrel.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: August 27, 2013
    Assignee: Comar, Inc.
    Inventors: David A. Manera, John D. Buehler
  • Patent number: 8459312
    Abstract: An adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: June 11, 2013
    Assignee: Comar, Inc.
    Inventors: David A. Manera, Victoria Moore O'Brien, Brian Myers, Daniel R. Hoffman, John D. Buehler
  • Publication number: 20120232114
    Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
    Type: Application
    Filed: May 22, 2012
    Publication date: September 13, 2012
    Applicant: Adolor Corporation
    Inventor: John D. Buehler
  • Publication number: 20100327010
    Abstract: An adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 30, 2010
    Inventors: David A. Manera, Victoria Moore O'Brien, Brian Myers, Daniel R. Hoffman, John D. Buehler
  • Publication number: 20100240690
    Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 23, 2010
    Applicant: Adolor Corporation
    Inventor: John D. Buehler
  • Patent number: 7700626
    Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: April 20, 2010
    Assignee: Adolor Corporation
    Inventor: John D. Buehler
  • Publication number: 20090062749
    Abstract: A dispenser assembly for liquid products is disclosed. Such an assembly may include an elongated barrel, and an elongated plunger having a flexible sealing lip disposed at an end thereof. The sealing lip may have an outer diameter in a relaxed state that is greater than an internal cross-sectional diameter of the barrel. When the plunger and barrel are actuated axially relative to one another, the sealing lip flexes inwardly and provides the sole contact between the plunger and the barrel.
    Type: Application
    Filed: February 12, 2008
    Publication date: March 5, 2009
    Applicant: Comar, Inc.
    Inventors: David A. Manera, John D. Buehler
  • Patent number: 7438552
    Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: October 21, 2008
    Assignee: Comar, Inc.
    Inventors: David A. Manera, John D. Buehler
  • Patent number: 7070581
    Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: July 4, 2006
    Assignee: Comar, Inc.
    Inventors: David A. Manera, John D. Buehler
  • Publication number: 20040040985
    Abstract: A container-closure assembly comprising a container having a body portion and a neck finish having external threads, a cap of cup-like form having a top and a skirt with internal threads to mate with the container threads for application and removal of the cap from the container, an elongated tubular dispensing member having a discharge opening at one end and mounting a bulbous member at the other end to draw liquid products in the container into the dispensing member, the body portion of the container having a downwardly dished bottom defining the lowest point at about the center of the bottom and means defining a series of circumferentially spaced protrusions projecting downwardly from the bottom wall defining support pads for supporting the container on a flat surface, the lowest point of the pads disposed in a common plane transverse to the longitudinal axis of the container and wherein the peak or apex of the slanted bottom wall is disposed above said common plane.
    Type: Application
    Filed: June 9, 2003
    Publication date: March 4, 2004
    Inventors: Brian Michael Gatton, John D. Buehler
  • Publication number: 20040007556
    Abstract: A container-closure assembly comprising a cap of cup-like form having a circumferentially expending skirt and a circumferentially extending flange depending from the top and spaced radially inwardly from the skirt and a series of radially inwardly directed circumferentially re-spaced lugs on the inner periphery of the skirt, the container having a neck portion with a discharge opening, the outer peripheral surface of the container being tapered upwardly and inwardly whereby the flexible flange engages the tapered surface when the cap is positioned over the container means defining a series of circumferentially re-spaced hook portions only on the container neck including a downwardly facing notched recess and a tapered face, said lugs position below a plain through the tip of the taper only hooks when the flexible flange lightly engages the tapered finish on the neck of the container.
    Type: Application
    Filed: May 23, 2003
    Publication date: January 15, 2004
    Inventors: David A. Manera, John D. Buehler
  • Publication number: 20040010238
    Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.
    Type: Application
    Filed: April 4, 2003
    Publication date: January 15, 2004
    Inventors: David A. Manera, John D. Buehler
  • Patent number: 6589484
    Abstract: The present invention provides a one-piece pipette/dropper assembly that includes a pipette portion, a threaded cap portion, and bulb portion. The cap potion has a top wall including a top and bottom surface and the bulb portion has a first end integrally formed with the top wall of the cap on the top surface. The pipette portion has a first end integrally formed with the top wall of the cap on the bottom surface thereof. The bulb potion communicates with the pipette potion through the first end of the pipette portion and the pipette portion has an opening in a second end for receiving and discharging a fluid.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: July 8, 2003
    Inventor: John D. Buehler
  • Patent number: 6565543
    Abstract: A drop dispenser having a sleeve carrying a closure and resilient dosage receiving fitting. The sleeve is treadably mounted on a fluid containing container having a nipple thereon. The closure on the sleeve has a configuration corresponding to the configuration of the nipple for sealing the nipple in the closed position. The fitting is filled with fluid from the container by turning the sleeve in a direction away from the closed position on the nipple to an open position to thereby establish fluid communication between the container and fitting. The fluid is dispensed from the fitting by squeezing the fitting after the closure has been returned to the closed position on the nipple, thereby preventing fluid from flowing from the resilient fitting back into the container. Cooperating stop members are provided between the sleeve and bottle neck to limit the movement of the sleeve relative to the bottle neck.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: May 20, 2003
    Assignee: Comar, Inc.
    Inventor: John D. Buehler