Patents by Inventor John D. Carpten

John D. Carpten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Prognosis, Diagnosis, Prevention and Treatment of Cancers
    Publication number: 20100120025
    Abstract: The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the present invention provides compositions which comprise an agent capable of eradicating or alleviating an abnormality in the EPHB2 gene or its related signaling pathways. This abnormality may cause or contribute to the development or progression of cancers. In another aspect, the present invention provides methods comprising detecting an abnormality in the EPHB2 gene or its related signaling pathways. The presence or absence of such an abnormality is indicative of the risk or disease status of cancer in a person of interest.
    Type: Application
    Filed: June 13, 2008
    Publication date: May 13, 2010
    Applicant: TGEN
    Inventors: Spyro Mousses, Pia Huusko, Olli-P Kallioniemi, John D. Carpten, David O. Azorsa, Jeffrey Kiefer
  • Compositions and methods for prognosis of cancers
    Patent number: 7402389
    Abstract: The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the present invention provides compositions which comprise an agent capable of eradicating or alleviating an abnormality in the EPHB2 gene or its related signaling pathways. This abnormality may cause or contribute to the development or progression of cancers. In another aspect, the present invention provides methods comprising detecting an abnormality in the EPHB2 gene or its related signaling pathways. The presence or absence of such an abnormality is indicative of the risk or disease status of cancer in a person of interest.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: July 22, 2008
    Assignee: The Translational Genomics Research Institute (TGen)
    Inventors: Spyro Mousses, Pia Huusko, Olli Kallioniemi, John D. Carpten, David O. Azorsa, Jeffrey Kiefer
  • Novel methods and reagents for the treatment of osteoarthritis
    Publication number: 20020086824
    Abstract: Methods and compositions are described for treating osteoarthritis. Treatment is described with a new class of anti-OA drug, namely compounds that may be used as lubricants of the tissue diagnosed with OA. Additionally, the present invention provides reagents for the screening of compounds that may be used as therapeutic agents in the treatment of OA.
    Type: Application
    Filed: March 8, 2001
    Publication date: July 4, 2002
    Applicant: Case Western Reserve University
    Inventors: Matthew L. Warman, John D. Carpten, Jeffery M. Trent, Jose Marcelino
  • Sequence modification of oligonucleotide primers to manipulate non-templated nucleotide addition
    Patent number: 6110710
    Abstract: The present invention is directed to methods for resisting or promoting template independent nucleotide addition to the 3' terminus of a DNA duplex. The process comprises amplifying a target nucleic acid using primers which comprise a 5' terminal sequence which resists or promotes non-templated nucleotide addition to the 3' terminus of the complementary nucleic acid strand. The invention is also directed to a kit for cloning 3' nucleotidylated duplex DNA.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: August 29, 2000
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jeffrey R. Smith, John D. Carpten, Michael J. Brownstein