Patents by Inventor John D. Cleary

John D. Cleary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and formulations for reducing amphotericin B treatment side effects
    Patent number: 8648050
    Abstract: A method of ameliorating amphotericin treatment side effects in a mammal that comprises administering a therapeutically effective amount of a formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B compound is present, in terms of polyene content, in an amount greater than 90%, and non-amphotericin B polyene compounds are present in an amount of no greater than 10%, and a pharmaceutically effective carrier; and administering a therapeutically effective amount of said formulation to a subject in need thereof.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: February 11, 2014
    Assignee: University of Mississippi
    Inventors: John D. Cleary, Stanley W. Chapman, Robert E. Kramer
  • METHODS AND FORMULATIONS FOR REDUCING AMPHOTERICIN B TREATMENT SIDE EFFECTS
    Publication number: 20110152211
    Abstract: A method of ameliorating amphotericin treatment side effects in a mammal that comprises administering a therapeutically effective amount of a formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B compound is present, in terms of polyene content, in an amount greater than 90%, and non-amphotericin B polyene compounds are present in an amount of no greater than 10%, and a pharmaceutically effective carrier; and administering a therapeutically effective amount of said formulation to a subject in need thereof.
    Type: Application
    Filed: January 5, 2011
    Publication date: June 23, 2011
    Inventors: John D. Cleary, Stanley W. Chapman, Robert E. Kramer
  • Compositions comprising highly purified amphotericin B
    Patent number: 7867981
    Abstract: A method for treating fungal infections in a mammal that includes administering a therapeutically effective amount of a composition comprising substantially pure amphotericin B and a pharmaceutically acceptable carrier. Amphotericin BHP is associated with decreased toxicity in mammals and cells measured by cell viability and expression of cytokine markers. Thus, this method allows for reduced adverse reactions when using amphotericin B products.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: January 11, 2011
    Assignee: University of Mississippi
    Inventors: John D. Cleary, Stanley W. Chapman, Robert E. Kramer