Patents by Inventor John D. DeNuzzio
John D. DeNuzzio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170216845Abstract: Enhanced composite liquid cell (CLC) devices and methods of using the same are provided. The devices find use in, among other applications, CLC mediated nucleic acid library generation protocols, e.g., for use in next generation sequencing applications.Type: ApplicationFiled: January 10, 2017Publication date: August 3, 2017Inventors: Brian Chawke, Jeffrey Sugarman, James Nealis, Jeffrey P. Baker, Mark Dalton, John D. DeNuzzio, Emma M. Kelly, Mitchell E. Gatesman
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Publication number: 20150018641Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: July 1, 2013Publication date: January 15, 2015Applicant: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 8808321Abstract: A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.Type: GrantFiled: January 11, 2011Date of Patent: August 19, 2014Assignee: Becton, Dickinson and CompanyInventors: John D. DeNuzzio, Steven Keith, Lawrence A. Monahan, Phyllis Palmer, Bill Stewart, Todd M. Chelak, Robert E. West, William Allen, Frederick Karl, Lee Griswold
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Publication number: 20120011705Abstract: A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.Type: ApplicationFiled: January 11, 2011Publication date: January 19, 2012Inventors: John D. DeNuzzio, Steven Keith, Lawrence A. Monahan, Phyllis Palmer, Bill Stewart, Todd M. Chelak, Robert E. West, William Allen, Frederick Karl, Lee Griswold
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Publication number: 20110184259Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: August 23, 2010Publication date: July 28, 2011Inventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith
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Patent number: 7959583Abstract: A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.Type: GrantFiled: February 9, 2007Date of Patent: June 14, 2011Assignee: Becton, Dickinson and CompanyInventors: John D. DeNuzzio, Steven Keith, Lawrence A. Monahan, Phyllis Palmer, Bill Stewart, Todd M. Chelak, Robert E. West, William Allen, Frederick Karl, Lee Griswold
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Patent number: 7792561Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: GrantFiled: August 16, 2007Date of Patent: September 7, 2010Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. Denuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 7787923Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: GrantFiled: October 19, 2004Date of Patent: August 31, 2010Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amis, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith
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Patent number: 7496392Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and may include at least one binding protein adapted to bind with at least one target analyte. The sensing element further may also include at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: GrantFiled: November 26, 2003Date of Patent: February 24, 2009Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcón, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 7426408Abstract: A minimally-invasive analyte detecting device and method for using the same. The system and method employ a device having an active electrode optionally coated with a substance, and a counter-electrode that is configured at least partially surround the active electrode. The configuration of the auxiliary electrode and active electrode improves the current flow through the device and increases the sensitivity of the device. When the device is placed against the patient's skin, the active electrode is adapted to enter through the stratum corneum of a patient to a depth less than a depth in the dermis at which nerve endings reside. An electric potential is applied to the active electrode and the analyte level is determined based on the amount of current or charge flowing through the device.Type: GrantFiled: August 2, 2004Date of Patent: September 16, 2008Assignee: Becton, Dickinson and CompanyInventors: John D. DeNuzzio, William E. Strohben, Jr.
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Publication number: 20080198358Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: ApplicationFiled: August 16, 2007Publication date: August 21, 2008Inventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. Denuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 7192405Abstract: A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.Type: GrantFiled: September 30, 2002Date of Patent: March 20, 2007Assignee: Becton, Dickinson and CompanyInventors: John D. DeNuzzio, Steven Keith, Lawrence A. Monahan, Phyllis Palmer, Bill Stewart, Todd M. Chelak, Robert E. West, William Allen, Frederick Karl, Lee Griswold
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Patent number: 7060059Abstract: A closed loop therapy system for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system that measures a glucose level in the body, a controller that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.Type: GrantFiled: October 14, 2003Date of Patent: June 13, 2006Assignee: Becton, Dickinson and CompanyInventors: Steven Keith, Robert S. Parker, Noel G. Harvey, Ronald J. Pettis, John D. DeNuzzio, Glenn Vonk
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Patent number: 6952604Abstract: A minimally-invasive analyte detecting device and method for using the same. The system and method employ a device having an active electrode optionally coated with a substance, and a counter-electrode that is configured at least partially surround the active electrode. The configuration of the auxiliary electrode and active electrode improves the current flow through the device and increases the sensitivity of the device. When the device is placed against the patient's skin, the active electrode is adapted to enter through the stratum corneum of a patient to a depth less than a depth in the dermis at which nerve endings reside. An electric potential is applied to the active electrode and the analyte level is determined based on the amount of current or charge flowing through the device.Type: GrantFiled: December 21, 2001Date of Patent: October 4, 2005Assignee: Becton, Dickinson and CompanyInventors: John D. DeNuzzio, William E. Strohben, Jr.
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Publication number: 20040152622Abstract: A closed loop therapy system for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system that measures a glucose level in the body, a controller that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.Type: ApplicationFiled: October 14, 2003Publication date: August 5, 2004Inventors: Steven Keith, Robert S. Parker, Noel G. Harvey, Ronald J. Pettis, John D. DeNuzzio, Glenn Vonk
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Publication number: 20040064068Abstract: A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.Type: ApplicationFiled: September 30, 2002Publication date: April 1, 2004Inventors: John D. DeNuzzio, Steven Keith, Lawrence A. Monahan, Phyllis Palmer, Bill Stewart, Todd M. Chelak, Robert E. West, William Allen, Frederick Karl, Lee Griswold
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Publication number: 20040040868Abstract: Sensors and methods of making the same are disclosed. Sensors are microfabricated with multiple working electrodes and a single, common counter electrode. The multiple working electrodes can be fabricated in different geometrical configurations for advantageously analyzing multiple components simultaneously in the same microcell sensor. Furthermore, sensors according to certain embodiments of the invention include openings to allow photometric analysis along with electroanalytical methods.Type: ApplicationFiled: June 19, 2003Publication date: March 4, 2004Inventors: John D. DeNuzzio, Erno Lindner, Robert E. Gyurcsanyi
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Publication number: 20040015063Abstract: A minimally-invasive analyte detecting device and method for using the same. The system and method employ a device having an active electrode optionally coated with a substance, and a counter-electrode that is configured at least partially surround the active electrode. The configuration of the auxiliary electrode and active electrode improves the current flow through the device and increases the sensitivity of the device. When the device is placed against the patient's skin, the active electrode is adapted to enter through the stratum corneum of a patient to a depth less than a depth in the dermis at which nerve endings reside. An electric potential is applied to the active electrode and the analyte level is determined based on the amount of current or charge flowing through the device.Type: ApplicationFiled: December 21, 2001Publication date: January 22, 2004Inventors: John D. DeNuzzio, William E. Strohben
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Publication number: 20020172969Abstract: Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.Type: ApplicationFiled: April 1, 2002Publication date: November 21, 2002Applicant: The Regents of the University of MichiganInventors: Mark A. Burns, David T. Burke, Brian N. Johnson, John D. DeNuzzio, Wayne F. Beyer
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Publication number: 20020168671Abstract: Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.Type: ApplicationFiled: April 1, 2002Publication date: November 14, 2002Applicant: The Regents of the University of MichiganInventors: Mark A. Burns, David T. Burke, Brian N. Johnson, John D. DeNuzzio, Wayne F. Beyer