Abstract: Methods and systems for extraction of analytes from samples for analysis using mass spectrometers are described herein.

Abstract: A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

Abstract: A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

Abstract: A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

Abstract: A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

Abstract: Methods and systems for extraction of analytes from samples for analysis using mass spectrometers are described herein.

Abstract: Atmospheric pressure ionization (API) interface structures such as API interface structures for mass spectrometers and related components, systems and methods are described herein.

Abstract: A novel atmospheric pressure ionization device for the transport of charged particle produced by at atmospheric pressure to a mass analyzer includes a liquid shield between the particle source and the sample inlet into the mass analyzer. The liquid shield may be in the form of a disk with a central aperture and acts as a spray splitter and aerofocusing device which increases the flow rate of a liquid sample into the analyzer. The mass analyzer is located in a high vacuum region and an intermediate low vacuum region is provided between the sample inlet and the analyzer. An ion optical system includes electrostatic lens assemblies in said vacuum regions for transporting charged particles from the inlet to the analyzer.

Abstract: An ion trap mass spectrometer includes an ion trap region separated from an electron multiplier region by a baffle, and separate turbomolecular pumps for pumping each region to a different pressure level. The ion trap region can therefore be pumped to a higher pressure level than ca be used for the electron multiplier region, and the result and increase in pressure of damping gas in the ion trap region increases the sensitivity of the device.

Abstract: An improved capillary zone electrophoresis (CZE)/ mass spectrometer interface comprises a liquid junction adapted to makeup the volume/flow rate of the CZE column eluent stream to be more compatible with the ion spray LC/MS interface flow rates required by mass spectrometer detectors in on-line separation/detection systems for variouscompositions and mixtures including biological fluids and environmental samples. Analytes eluting from the CZE capillary column are diluted with a suitable buffer thereby adjusting the volume and flow rates to prevent flow and pressure discrepanies which would otherwise result in peak broadening.The new liquid junction system for CZE/MS and CZE/MS/MS is useful in separating, detecting and analyzing compositions and mixtures such as amino acids, pesticides, peptides, mucleotides, sulfonated azo dyes and enzymatic digests such as tryptic digest of recombinant bovine somatotropan. Detection can be carried out in both positive and negative ion modes.

Abstract: A Thermal-Assisted Electrospray Interface (TAESI) used in series between a liquid chromatograph and a mass analyzer gives increased sensitivity for detection of components in a liquid stream at high flow rates up to 2 milliliters per minute. Liquid exiting the liquid chromatograph is sprayed through a stainless steel capillary tube while being heated externally and under an applied voltage of about 3 KV. The combination of thermal energy and electric field potential disperses the liquid into a fine mist which is then directed at atmospheric pressure into the ionization chamber of a mass spectrometer. Such a system, optionally may additionally contain a high velocity gas flow neubulization means.The TAESI interface may be used without the electric field; however at flow rates of from 500 to 1000 .mu.L/min the use of both electric field and thermal energy increases the sensitivity by two orders of magnitude over the interface used without the electric field.

Abstract: A device for interfacing between a microbore liquid chromatograph and a mass analyser. In such a device, liquid from the liquid chromatograph is sprayed through a stainless steel capillary tube into the atmospheric pressure ionization chamber of a mass spectrometer. A voltage of e.g., plus or minus 3 KV is applied to the stainless steel tube, and a nebulizing gas, e.g. nitrogen, is directed at high velocity past the tube tip through another tube encircling the stainless steel tube. The combination of the nebulizing gas and the electric potential disperses the liquid at room temperature into a fine mist providing an increased and more stable ion signal without thermal decomposition of the compounds being analysed.