Patents by Inventor John D. Higgins

John D. Higgins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR TREATING CONDITIONS RELATED TO PCSK9 ACTIVITY
    Publication number: 20240238367
    Abstract: The present disclosure provides a method of treating hypercholesterolemia and other conditions related to PCSK9 activity, e.g. atherosclerosis, atherosclerotic cardiovascular disease, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions, by orally administering to the subject an amount of a compound of formula (I) wherein A? is selected from a pharmaceutically acceptable anion, and wherein the amount administered is from about 5 mg to about 300 mg of the compound of formula (I). The present invention is also directed to pharmaceutical compositions comprising a compound of formula (I), including particular salts of a compound of formula (I), and a permeation enhancer.
    Type: Application
    Filed: August 18, 2022
    Publication date: July 18, 2024
    Inventors: Douglas G. JOHNS, Puja BANKA, Zexun ZHOU, Artis KLAPARA, Fuh-rong TSAY, Jongrock KONG, Richard J. VARSOLONA, Richard DESMOND, Peter E. MALIGRES, Melanie MAROTA, Candice ALLEYNE, Grace A. OKOH, James C. DINUNZIO, Rebecca NOFSINGER, Li LI, Daniel J. SMITH, Majid MAHJOUR, Kenneth Alan KOEPLINGER, Yusheng XIONG, Peter W. WUEFLING, John D. HIGGINS
  • Amorphous solid dispersions
    Patent number: 7713548
    Abstract: Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: May 11, 2010
    Assignee: sanofi-aventis U.S. LLC
    Inventors: Irwin C. Jacobs, John D. Higgins, Micael Guillot, Nancy M. Franson, William L. Rocco, Khawla Abdullah Abu-Izza
  • Crystalline form
    Patent number: 7683062
    Abstract: Disclosed are a novel crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, processes of preparing said crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, compositions comprising said form in admixture with one or more pharmaceutically acceptable excipients, and uses for the same.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: March 23, 2010
    Assignee: sanofi-aventis U.S. LLC
    Inventors: William Rocco, John D. Higgins
  • AMORPHOUS SOLID DISPERSIONS
    Publication number: 20080160080
    Abstract: Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.
    Type: Application
    Filed: February 12, 2008
    Publication date: July 3, 2008
    Applicant: SANOFI-AVENTIS U.S. LLC
    Inventors: Irwin C. Jacobs, John D. Higgins, Micael Guillot, Nancy M. Franson, William L. Rocco, Khawla Abdullah Abu-Izza
  • NOVEL CRYSTALLINE FORM
    Publication number: 20080139569
    Abstract: Disclosed are a novel crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, processes of preparing said crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, compositions comprising said form in admixture with one or more pharmaceutically acceptable excipients, and uses for the same.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 12, 2008
    Applicant: SANOFI-AVENTIS U.S. LLC.
    Inventors: William L. ROCCO, John D. HIGGINS
  • Sterol esters in tableted solid dosage forms
    Patent number: 6376481
    Abstract: The present invention provides a sterol, stanol or their corresponding acid ester in a form suitable for the manufacture of an oral dosage form. A method for producing the oral dosage form is also provided.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: April 23, 2002
    Assignee: McNeil-PPC, Inc.
    Inventors: Richard D. Bruce, John D. Higgins, Stephen A. Martellucci