Patents by Inventor John D. Higgins
John D. Higgins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7713548Abstract: Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.Type: GrantFiled: February 12, 2008Date of Patent: May 11, 2010Assignee: sanofi-aventis U.S. LLCInventors: Irwin C. Jacobs, John D. Higgins, Micael Guillot, Nancy M. Franson, William L. Rocco, Khawla Abdullah Abu-Izza
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Patent number: 7683062Abstract: Disclosed are a novel crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, processes of preparing said crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, compositions comprising said form in admixture with one or more pharmaceutically acceptable excipients, and uses for the same.Type: GrantFiled: February 14, 2008Date of Patent: March 23, 2010Assignee: sanofi-aventis U.S. LLCInventors: William Rocco, John D. Higgins
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Publication number: 20080160080Abstract: Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.Type: ApplicationFiled: February 12, 2008Publication date: July 3, 2008Applicant: SANOFI-AVENTIS U.S. LLCInventors: Irwin C. Jacobs, John D. Higgins, Micael Guillot, Nancy M. Franson, William L. Rocco, Khawla Abdullah Abu-Izza
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Patent number: 6399137Abstract: The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.Type: GrantFiled: July 26, 2000Date of Patent: June 4, 2002Assignee: McNeil-PPC, Inc.Inventors: Clemence K. Dartey, John D. Higgins, III, Richard D. Bruce, Brid T. Burruano
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Patent number: 6376481Abstract: The present invention provides a sterol, stanol or their corresponding acid ester in a form suitable for the manufacture of an oral dosage form. A method for producing the oral dosage form is also provided.Type: GrantFiled: September 2, 1998Date of Patent: April 23, 2002Assignee: McNeil-PPC, Inc.Inventors: Richard D. Bruce, John D. Higgins, Stephen A. Martellucci
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Patent number: 6184397Abstract: The present invention provides a method for the direct esterification of stanols and sterols with catalyst, which can be acidic or basic, in the presence of a color deactivating agent to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free of organic solvents or mineral acids.Type: GrantFiled: June 21, 1999Date of Patent: February 6, 2001Assignee: McNeil-PPC, Inc.Inventors: Allan Roden, James L. Williams, Ruey Bruce, Frank Detrano, Marie H. Boyer, John D. Higgins, III
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Patent number: 6160020Abstract: Isolated salts of acetaminophen are disclosed. Alkali metal and alkaline-earth metal salts of acetaminophen were formed by reacting the free acid of acetaminophen with the corresponding metal hydroxide and then immediately isolating the resulting salt. These salts have been found to be more water soluble and less bitter in taste than the free acid form of acetaminophen. The isolated salts may also be combined with other active ingredients.Type: GrantFiled: June 19, 1998Date of Patent: December 12, 2000Assignee: McNeill-PPC, Inc.Inventors: Lena A. Ohannesian, David Nadig, John D. Higgins, III, Max Rey, Stephen A. Martellucci
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Patent number: 6147236Abstract: The present invention provides a method for the direct esterification of stanols and sterols with fatty acids to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free ot organic solvents or mineral acids.Type: GrantFiled: December 15, 1998Date of Patent: November 14, 2000Assignee: McNeil-PPC, Inc.Inventor: John D. Higgins, III
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Patent number: 6123978Abstract: The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.Type: GrantFiled: August 31, 1998Date of Patent: September 26, 2000Assignee: McNeil-PPC, Inc.Inventors: Clemence K. Dartey, John D. Higgins, III, Richard D. Bruce, Brid T. Burruano
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Patent number: 6054144Abstract: A method for preparing .beta.-sitosterol, oryzanol, esters of both of these compounds and related compounds are disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.Type: GrantFiled: November 4, 1998Date of Patent: April 25, 2000Assignee: McNeil-PPC, Inc.Inventors: Brid Burruano, Richard D. Bruce, Michael R. Hoy, John D. Higgins, III
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Patent number: 5892068Abstract: The present invention provides a method for the direct esterification of stanols and sterols with fatty acids to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free of organic solvents or mineral acids.Type: GrantFiled: August 25, 1998Date of Patent: April 6, 1999Assignee: McNeil-PPC, Inc.Inventor: John D. Higgins, III
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Patent number: 5792444Abstract: The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX--Y--Leu--Phe--?Z!.sub.n --Wwherein:X is an amino protecting group,Y is an amino acid residue,Z is a spacer sequence,n is 0 or 1, andW is a labeling or attachment substituent.Type: GrantFiled: October 22, 1993Date of Patent: August 11, 1998Assignees: The General Hospital Corporation, Johnson Matthey, Inc., Ortho Pharmaceutical CorporationInventors: Alan J. Fischman, Howard F. Solomon, Claudia K. Derian, Gary J. Bridger, John D. Higgins, III, Scott K. Larsen, Pedro E. Hernandez, Robert H. Rubin, H. William Strauss, Anthony J. Fuccello, Daniel J. Kroon
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Patent number: 5350837Abstract: The ligand L, (R.sup.3)(R.sup.4)(R.sup.5)C--N(R)--C(R.sup.1)(R.sup.2)--(CH.sub.2).sub.n --COOH L where R is hydrogen, hydroxy, alkyl, hydroxyalkyl, or alkylcarboxy, or R and R.sup.1 together may form a mono-, di-, tri-, or tetra-methylene radical, or R and R.sup.3 together may form a mono-, di-, tri-, or tetra-methylene radical, and R.sup.1 and R.sub.2 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, alkylamine, alkylthiol, aryl or R.sup.1 and R.sup.2 together may form a tetra- or penta-methylene radical, and R.sup.3 and R.sup.4 and R.sup.5 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, provided that at least one of R.sup.3, R.sup.4 and R.sup.5 is hydroxyalkyl, and n is equal to 0, 1 or 2, for example tricine, form useful complexes with .sup.99m Tc, for radiolabelling macromolecules such as monoclonal antibodies.Type: GrantFiled: May 3, 1993Date of Patent: September 27, 1994Assignee: Johnson Matthey Public Limited CompanyInventors: Gary J. Bridger, Pedro E. Hernandez, John D. Higgins, III, Scott K. Larsen