Patents by Inventor John D. Higgins, III

John D. Higgins, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6399137
    Abstract: The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: June 4, 2002
    Assignee: McNeil-PPC, Inc.
    Inventors: Clemence K. Dartey, John D. Higgins, III, Richard D. Bruce, Brid T. Burruano
  • Patent number: 6184397
    Abstract: The present invention provides a method for the direct esterification of stanols and sterols with catalyst, which can be acidic or basic, in the presence of a color deactivating agent to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free of organic solvents or mineral acids.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: February 6, 2001
    Assignee: McNeil-PPC, Inc.
    Inventors: Allan Roden, James L. Williams, Ruey Bruce, Frank Detrano, Marie H. Boyer, John D. Higgins, III
  • Patent number: 6160020
    Abstract: Isolated salts of acetaminophen are disclosed. Alkali metal and alkaline-earth metal salts of acetaminophen were formed by reacting the free acid of acetaminophen with the corresponding metal hydroxide and then immediately isolating the resulting salt. These salts have been found to be more water soluble and less bitter in taste than the free acid form of acetaminophen. The isolated salts may also be combined with other active ingredients.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: December 12, 2000
    Assignee: McNeill-PPC, Inc.
    Inventors: Lena A. Ohannesian, David Nadig, John D. Higgins, III, Max Rey, Stephen A. Martellucci
  • Patent number: 6147236
    Abstract: The present invention provides a method for the direct esterification of stanols and sterols with fatty acids to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free ot organic solvents or mineral acids.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: November 14, 2000
    Assignee: McNeil-PPC, Inc.
    Inventor: John D. Higgins, III
  • Patent number: 6123978
    Abstract: The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: September 26, 2000
    Assignee: McNeil-PPC, Inc.
    Inventors: Clemence K. Dartey, John D. Higgins, III, Richard D. Bruce, Brid T. Burruano
  • Patent number: 6054144
    Abstract: A method for preparing .beta.-sitosterol, oryzanol, esters of both of these compounds and related compounds are disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: April 25, 2000
    Assignee: McNeil-PPC, Inc.
    Inventors: Brid Burruano, Richard D. Bruce, Michael R. Hoy, John D. Higgins, III
  • Patent number: 5892068
    Abstract: The present invention provides a method for the direct esterification of stanols and sterols with fatty acids to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free of organic solvents or mineral acids.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: April 6, 1999
    Assignee: McNeil-PPC, Inc.
    Inventor: John D. Higgins, III
  • Patent number: 5792444
    Abstract: The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX--Y--Leu--Phe--?Z!.sub.n --Wwherein:X is an amino protecting group,Y is an amino acid residue,Z is a spacer sequence,n is 0 or 1, andW is a labeling or attachment substituent.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: August 11, 1998
    Assignees: The General Hospital Corporation, Johnson Matthey, Inc., Ortho Pharmaceutical Corporation
    Inventors: Alan J. Fischman, Howard F. Solomon, Claudia K. Derian, Gary J. Bridger, John D. Higgins, III, Scott K. Larsen, Pedro E. Hernandez, Robert H. Rubin, H. William Strauss, Anthony J. Fuccello, Daniel J. Kroon
  • Patent number: 5350837
    Abstract: The ligand L, (R.sup.3)(R.sup.4)(R.sup.5)C--N(R)--C(R.sup.1)(R.sup.2)--(CH.sub.2).sub.n --COOH L where R is hydrogen, hydroxy, alkyl, hydroxyalkyl, or alkylcarboxy, or R and R.sup.1 together may form a mono-, di-, tri-, or tetra-methylene radical, or R and R.sup.3 together may form a mono-, di-, tri-, or tetra-methylene radical, and R.sup.1 and R.sub.2 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, alkylamine, alkylthiol, aryl or R.sup.1 and R.sup.2 together may form a tetra- or penta-methylene radical, and R.sup.3 and R.sup.4 and R.sup.5 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, provided that at least one of R.sup.3, R.sup.4 and R.sup.5 is hydroxyalkyl, and n is equal to 0, 1 or 2, for example tricine, form useful complexes with .sup.99m Tc, for radiolabelling macromolecules such as monoclonal antibodies.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: September 27, 1994
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Gary J. Bridger, Pedro E. Hernandez, John D. Higgins, III, Scott K. Larsen