Patents by Inventor John D. Imig

John D. Imig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND COMPOSITIONS FOR TREATING KIDNEY DISEASE
    Publication number: 20220273593
    Abstract: The invention is based on a class of dual modulators of soluble epoxide hydrolase (sEH) and farnesoid X receptor (FXR), in particular of compounds having an activity as FXR agonist and sEH inhibitor for the treatment or prevention of kidney diseases and/or fibrotic diseases. The invention provides the compounds for use in such treatments and preventions as well as pharmaceutical compositions comprising the compounds as active ingredients.
    Type: Application
    Filed: September 21, 2020
    Publication date: September 1, 2022
    Inventors: JOHN D. IMIG, DANIEL MERK, ABDUL HYE KHAN, MORITZ HELMSTÄDTER
  • KIDNEY-TARGETED EPOXYEICOSATRIENOIC ACID (EET) ANALOGS
    Publication number: 20220251100
    Abstract: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
    Type: Application
    Filed: April 26, 2022
    Publication date: August 11, 2022
    Inventors: John D. Imig, John R. Falck, Abdul Hye Khan, Adeniyi Adebesin
  • Substituted epoxyeicosatrienoic acid (EET) analogs for treatment of kidney disease
    Patent number: 11358968
    Abstract: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: June 14, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: John D. Imig, John R. Falck, Abdul Hye Khan, Adeniyi Adebesin
  • KIDNEY-TARGETED EPOXYEICOSATRIENOIC ACID (EET) ANALOGS
    Publication number: 20200255433
    Abstract: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
    Type: Application
    Filed: September 14, 2018
    Publication date: August 13, 2020
    Applicant: THE MEDICAL COLLEGE OF WISCONSIN, INC.
    Inventors: John D. Imig, John R. Falck, Abdul Hye Khan, Adeniyi ADEBESIN
  • Compositions and methods for the treatment of renal and cardiovascular disease
    Patent number: 7732470
    Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 8, 2010
    Assignees: Medical College of Georgia Research Institute, Board of Regents, The University of Texas System
    Inventors: John D. Imig, John R. Falck
  • Compositions and methods for the treatment of renal and cardiovascular disease
    Patent number: 7550617
    Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: June 23, 2009
    Assignees: Medical College of Georgia Research Institute, Board of Regents, The University of Texas System
    Inventors: John D. Imig, John R. Falck
  • Compositions and Methods for the Treatment of Renal and Cardiovascular Disease
    Publication number: 20080153889
    Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds.
    Type: Application
    Filed: February 29, 2008
    Publication date: June 26, 2008
    Inventors: John D. Imig, John R. Falck
  • Compositions and Methods for the Treatment of Renal and Cardiovascular Disease
    Publication number: 20080146663
    Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
    Type: Application
    Filed: October 2, 2007
    Publication date: June 19, 2008
    Inventors: John D. Imig, John R. Falck