Abstract: Various embodiments disclosed relate to an abrasive sheet. The abrasive sheet includes a first layer including an abrasive major surface and an opposite second layer defining a second major surface. The second major surface includes a plurality of protrusions extending outwardly from the second major surface. The protrusions include a first polymer component having at least one of a Shore A hardness ranging from about 5 to about 100 and a Shore D hardness ranging from about 1 to about 70. The first layer and the second layer are directly joined to each other.

Abstract: This disclosure relates to the unexpected discovery that agents capable of inhibiting calcium channels, such as calcium channel blockers, are effective in treating or alleviating the symptoms of myotonic disorders. In patients who have been diagnosed with the condition, the methods of this disclosure can, e.g., reverse or inhibit the worsening of symptoms related to such condition and/or prevent development of new symptoms.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: This invention relates to compositions and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the invention relate to polynucleotides, vectors, and host cells, and uses thereof.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.