Patents by Inventor John D. Lueck

John D. Lueck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Rescuing Stop Codons via Genetic Reassignment with ACE-tRNA
    Publication number: 20230407300
    Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.
    Type: Application
    Filed: April 21, 2023
    Publication date: December 21, 2023
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher AHERN, John D. LUECK
  • ENCODING AND EXPRESSION OF ACE-tRNAs
    Publication number: 20230272378
    Abstract: This invention relates to compositions and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the invention relate to polynucleotides, vectors, and host cells, and uses thereof.
    Type: Application
    Filed: June 7, 2021
    Publication date: August 31, 2023
    Applicant: University of Rochester
    Inventors: John D. Lueck, Joseph J. Porter, Charles A. Thornton, Wooree Ko
  • Methods of rescuing stop codons via genetic reassignment with ACE-tRNA
    Patent number: 11661600
    Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: May 30, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher Ahern, John D. Lueck
  • METHODS OF RESCUING STOP CODONS VIA GENETIC REASSIGNMENT WITH ACE-TRNA
    Publication number: 20200291401
    Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.
    Type: Application
    Filed: November 2, 2018
    Publication date: September 17, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher Ahern, John D. Lueck