Patents by Inventor John D. Munger, Jr.

John D. Munger, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors
    Patent number: 8859784
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: October 14, 2014
    Assignee: Codexis, Inc.
    Inventors: Jack Liang, James Lalonde, Jun Zhu, John M. Gruber, John D. Munger, Jr.
  • Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds
    Patent number: 8574876
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: November 5, 2013
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds
    Publication number: 20120244581
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: March 30, 2012
    Publication date: September 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors
    Publication number: 20120130087
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 24, 2012
    Applicant: CODEXIS, INC.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
    Patent number: 8178333
    Abstract: The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 15, 2012
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
    Publication number: 20100063300
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: June 23, 2009
    Publication date: March 11, 2010
    Applicant: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Nucleotide analog compositions
    Patent number: 6451340
    Abstract: The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: September 17, 2002
    Assignee: Gilead Sciences, Inc.
    Inventors: Murty N. Arimilli, Daphne E. Kelly, Thomas T. K. Lee, Lawrence V. Manes, John D. Munger, Jr., Ernest J. Prisbe, Lisa M. Schultze
  • Preparation of carbocyclic compounds
    Patent number: 6057459
    Abstract: The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 2, 2000
    Assignee: Gilead Sciences, Inc.
    Inventors: Kenneth M. Kent, Choung U. Kim, Lawrence R. McGee, John D. Munger, Jr., Ernest J. Prisbe, Michael J. Postich, John C. Rohloff, Daphne E. St. John, Matthew A. Williams, Lijun Zhang
  • Nucleotide analog composition and synthesis method
    Patent number: 5935946
    Abstract: The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: August 10, 1999
    Assignee: Gilead Sciences, Inc.
    Inventors: John D. Munger, Jr., John C. Rohloff, Lisa M. Schultze
  • Preparation of carbocyclic compounds
    Patent number: 5859284
    Abstract: The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: January 12, 1999
    Assignee: Gilead Sciences, Inc.
    Inventors: Kenneth M. Kent, Choung U. Kim, Lawrence R. McGee, John D. Munger, Jr., Ernest J. Prisbe, Michael J. Postich, John C. Rohloff, Daphne E. St. John, Matthew A. Williams, Lijun Zhang