Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Described herein are methods for treating radicular pain due to radiculopathies comprising administering a therapeutically effective amount of a composition comprising cell-free amniotic fluid.

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)-O—, levulinyl (Lev)-O—, and a phosphoramidite.

Abstract: The present disclosure relates to a cell-free sterile filtered amniotic fluid that may be processed and/or supplemented to treat lung inflammation and/or fibrosis caused by lung disease.

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)—O—, levulinyl (Lev)—O—, and a phosphoramidite.

Abstract: Improved systems and methods for dosing agent injection adaptation for a selective catalytic reduction (SCR) system of an engine of a vehicle involve an adaptation procedure that is generally divided into distinct phases based upon the requirement to obtain an accurate dosing adaptation. The phases themselves provide the specific functions of catalyst ammonia storage depletion, catalyst ammonia storage and NOx conversion stabilization, and adaptation value factor determination and verification.

Abstract: Systems and methods of preventing thermal spikes at a catalyst in an exhaust system of an engine of a vehicle include detecting whether one of a fuel enrichment event and a fuel cutoff event has been initiated and in response, temporarily disabling the other of the fuel enrichment event and the fuel cutoff event from occurring to prevent an exhaust gas temperature thermal spike that could damage the catalyst, while the other of the fuel enrichment event and the fuel cutoff event is disabled, performing stoichiometric closed-loop fuel control using the one or more oxygen sensors to drive the exhaust gas fuel/air ratio to stoichiometry and an oxygen storage capacity of the catalyst to a balanced state, and when measurements from the one or more oxygen sensors indicate at least one lean-to-rich transition and one rich-to-lean transition in the exhaust gas oxygen level has occurred, re-enabling the other event.

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2-CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)—O—, levulinyl (Lev)—O—, and a phosphoramidite.

Abstract: Improved systems and methods for dosing agent injection adaptation for a selective catalytic reduction (SCR) system of an engine of a vehicle involve an adaptation procedure that is generally divided into distinct phases based upon the requirement to obtain an accurate dosing adaptation. The phases themselves provide the specific functions of catalyst ammonia storage depletion, catalyst ammonia storage and NOx conversion stabilization, and adaptation value factor determination and verification.

Abstract: A laminated shingle has a rendered shadow design when placed with other similar shingles on a roof deck. The laminated shingle includes an overlay member and an underlay member fixedly attached to each other. The overlay member includes an upper or headlamp portion and a lower or exposed butt portion with one or more tabs separated by cutouts. The overlay member is also coated with a layer of relatively dark granules to form horizontally-oriented overlay shading areas on the upper and lower edges of the tabs. The underlay member is coated with a layer of relatively dark granules to form vertically and horizontally-oriented underlay shading areas. In one embodiment, one or both vertical edges of each tab are generally parallel to the vertically-oriented longitudinal axis of the vertically-oriented shading area to expose a portion of the shading area.

Abstract: A laminated shingle has a rendered shadow design when placed with other similar shingles on a roof deck. The laminated shingle includes an overlay member and an underlay member fixedly attached to each other. The overlay member includes an upper or headlap portion and a lower or exposed butt portion with one or more tabs separated by cutouts. The overlay member is also coated with a layer of relatively dark granules to form horizontally-oriented overlay shading areas on the upper and lower edges of the tabs. The underlay member is coated with a layer of relatively dark granules to form vertically and horizontally-oriented underlay shading areas. In one embodiment, one or both vertical edges of each tab are generally parallel to the vertically-oriented longitudinal axis of the vertically-oriented shading area to expose a portion of the shading area.

Abstract: A method of making shingles includes coating a shingle mat with roofing asphalt to make an asphalt-coated sheet, and covering the asphalt-coated sheet with granules to form a granule-covered sheet along a longitudinal axis, the granule-covered sheet having a shadow patch thereon, the shadow patch having a first width along the longitudinal axis. The granule-covered sheet is divided into an overlay sheet and an underlay sheet, the shadow patch being on the underlay sheet. A pattern of tabs and cutouts is cut in the overlay sheet, one of the tabs of the pattern being a select tab having a second width along the longitudinal axis, the second width of the select tab being less than the first width of the shadow patches. The relative longitudinal positions of the shadow patch and the select tab are synchronized.

Abstract: A method of producing asphalt strip shingles includes continuously coating a substrate with asphalt to form an asphalt coated sheet, moving the asphalt coated sheet in a machine direction, depositing blend drops of blend drop granules onto the asphalt coated sheet from a blender, providing a signal indicative of the presence of the blend drops at a location downstream from the blender, sensing the color of the blend drops at the downstream location with a sensor, comparing the sensed color of the blend drops with a reference color, and providing a signal indicative of the comparison.

Abstract: A system and method is disclosed that uses an empirically-derived thermal transfer function for an ignition coil taken with respect to an ambient temperature and responsive internal temperatures. The system combines the transfer function with a minimum cure-induced stress profile, in order to obtain a time-temperature profile for minimizing cure-induced residual stress in an epoxy resin impregnated ignition coil. An accelerated minimal-stress profile is obtained by increasing an initial gel isotherm temperature of the above-mentioned time-temperature profile.

Abstract: A multi-layer laminate roofing shingle having a first sheet with a first marginal edge, an intermediate sheet with a second marginal edge, and a bottom sheet with a third marginal edge. The first sheet has a defined width (L), the intermediate sheet is about ⅔ the width of the first sheet, and the bottom sheet is about ⅓ the width of the first sheet. The first, intermediate and bottom sheets are arranged so that marginal edges coincide with one another. When applied to a roof, the multi-layer laminate shingle creates the appearance of depth on the roof.

Abstract: A laminated shingle has a rendered shadow design when placed with other similar shingles on a roof deck. The laminated shingle includes an overlay member and an underlay member fixedly attached to each other. The overlay member includes an upper or headlap portion and a lower or exposed butt portion with one or more tabs separated by cutouts. The overlay member is also coated with a layer of relatively dark granules to form horizontally-oriented overlay shading areas on the upper and lower edges of the tabs. The underlay member is coated with a layer of relatively dark granules to form vertically and horizontally-oriented underlay shading areas. In one embodiment, one or both vertical edges of each tab are generally parallel to the vertically-oriented longitudinal axis of the vertically-oriented shading area to expose a portion of the shading area.

Abstract: A method of making shingles includes coating a shingle mat with roofing asphalt to make an asphalt-coated sheet, and covering the asphalt-coated sheet with granules to form a granule-covered sheet along a longitudinal axis, the granule-covered sheet having a shadow patch thereon, the shadow patch having a first width along the longitudinal axis. The granule-covered sheet is divided into an overlay sheet and an underlay sheet, the shadow patch being on the underlay sheet. A pattern of tabs and cutouts is cut in the overlay sheet, one of the tabs of the pattern being a select tab having a second width along the longitudinal axis, the second width of the select tab being less than the first width of the shadow patches. The relative longitudinal positions of the shadow patch and the select tab are synchronized.

Abstract: A system and method is disclosed that uses an empirically-derived thermal transfer function for an ignition coil taken with respect to an ambient temperature and responsive internal temperatures. The system combines the transfer function with a minimum cure-induced stress profile, in order to obtain a time-temperature profile for minimizing cure-induced residual stress in an epoxy resin impregnated ignition coil. An accelerated minimal-stress profile is obtained by increasing an initial gel isotherm temperature of the above-mentioned time-temperature profile.