Patents by Inventor John D. Sharp

John D. Sharp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
    Publication number: 20020055139
    Abstract: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: March 1, 2001
    Publication date: May 9, 2002
    Inventors: Douglas A. Holtzman, John D. Sharp, Kevin R. Leiby, Steven Bossone, Yang Pan, Thomas M. Barnes, Christopher C. Fraser, Nicholas Wrighton, Paul S. Myers, Gillian Kingsbury
  • Human phospholipase A2 and related nucleic acid compounds
    Patent number: 6242206
    Abstract: The invention provides a novel phospholipase A2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: June 5, 2001
    Assignee: Eli Lilly and Company
    Inventors: Xue-Chiou C. Choiu, Ruth M. Kramer, Richard T. Pickard, John D. Sharp, Beth A. Strifler
  • Human phospholipase A2 and related nucleic acid compounds
    Patent number: 6197569
    Abstract: The invention provides a novel phospholipase A2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic add cascade.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: March 6, 2001
    Assignee: Eli Lilly and Company
    Inventors: Xue-Chiou C. Choiu, Ruth M. Kramer, Richard T. Pickard, John D. Sharp, Beth A. Strifler
  • Human phospholipase A.sub.2 and related nucleic acid compounds
    Patent number: 6025178
    Abstract: The invention provides a novel phospholipase A.sub.2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: February 15, 2000
    Assignee: Eli Lilly and Company
    Inventors: Xue-Chiou C. Choiu, Ruth M. Kramer, Richard T. Pickard, John D. Sharp, Beth A. Strifler
  • Compounds, vectors and methods for expressing human, cytosolic phospholipase A.sub.2
    Patent number: 5328842
    Abstract: The invention includes recombinant DNA compounds, vectors and methods useful for expressing an exceptionally rare, human, cytosolic phospholipase A.sub.2 (cPLA.sub.2) enzyme. The invention also includes a method for screening compounds to identify inhibitors of cPLA.sub.2 which is believed to partake in several disease processes.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: July 12, 1994
    Assignee: Eli Lilly and Company
    Inventors: Xue-Chiou C. Chiou, JoAnn Hoskins, Ruth M. Kramer, John D. Sharp, Donald L. White
  • Multi-functional hypobromide precursors
    Patent number: 4451376
    Abstract: An improved method for treating alkaline industrial process waters to control the growth and deposit of microorganisms which comprises adding to such waters a combination of a water-soluble anionic polymeric dispersant having a molecular weight not greater than 50,000 and hypobromous acid, said hypobromous acid having been produced by contacting a solution containing:(a) a water-soluble inorganic bromide, and(b) an anionic polymeric dispersantwith a chlorine containing oxidant chosen from the group consisting of an inorganic hypochlorite salt, hypochlorous acid, and chlorine.
    Type: Grant
    Filed: July 28, 1983
    Date of Patent: May 29, 1984
    Assignee: Nalco Chemical Company
    Inventor: John D. Sharp