Patents by Inventor John Dallas Pruitt
John Dallas Pruitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9052442Abstract: The invention provides a cost-effective and in-situ method for applying an LbL coating onto a silicone hydrogel contact lens directly in a lens package. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, intactness and durability and also can be used directly from the lens package by a patient without washing and/or rising. In addition, the invention provides a packaging solution for in-situ coating of a silicone hydrogel contact lens in a lens package and an ophthalmic lens product.Type: GrantFiled: October 29, 2007Date of Patent: June 9, 2015Assignee: Novartis AGInventors: John Dallas Pruitt, Lynn Cook Winterton, Sai Ramamurthy Kumar, Dawn A. Smith
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Publication number: 20150153482Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.Type: ApplicationFiled: February 9, 2015Publication date: June 4, 2015Inventors: Frank Chang, Robert Scott, Jinyu Huang, Arturo N. Medina, Dawn A. Smith, Laura A. Sanders, John Dallas Pruitt
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Publication number: 20150099822Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: December 16, 2014Publication date: April 9, 2015Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Publication number: 20150092156Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.Type: ApplicationFiled: December 9, 2014Publication date: April 2, 2015Inventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
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Patent number: 8987403Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.Type: GrantFiled: August 30, 2013Date of Patent: March 24, 2015Assignee: Novartis AGInventors: Frank Chang, Robert Scott, Jinyu Huang, Arturo N. Medina, Dawn A. Smith, Laura A. Sanders, John Dallas Pruitt
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Patent number: 8944592Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: July 23, 2013Date of Patent: February 3, 2015Assignee: Novartis AGInventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 8939577Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.Type: GrantFiled: May 22, 2013Date of Patent: January 27, 2015Assignee: Novartis AGInventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
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Publication number: 20140174031Abstract: The present invention generally relates to a method for applying a coating of hydrophilic polymers onto silicone hydrogel contact lenses to improve hydrophilicity and lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rising.Type: ApplicationFiled: December 10, 2013Publication date: June 26, 2014Applicant: Novartis AGInventors: Yongxing Qiu, Arturo Norberto Medina, John Dallas Pruitt
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Publication number: 20140096484Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.Type: ApplicationFiled: December 11, 2013Publication date: April 10, 2014Applicant: Novartis AGInventors: John Dallas Pruitt, Lynn Cook Winterton
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Patent number: 8647658Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.Type: GrantFiled: August 27, 2008Date of Patent: February 11, 2014Assignee: Novartis AGInventors: John Dallas Pruitt, Lynn Cook Winterton
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Publication number: 20140005430Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.Type: ApplicationFiled: August 30, 2013Publication date: January 2, 2014Applicant: Novartis AGInventors: Frank Chang, Robert Scott, Jinyu Huang, Arturo N. Medina, Dawn A. Smith, Laura A. Sanders, John Dallas Pruitt
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Publication number: 20130337160Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.Type: ApplicationFiled: June 10, 2013Publication date: December 19, 2013Inventors: Troy Vernon Holland, Frank Chang, Yongxing Qiu, John Dallas Pruitt, Chung-Yuan Chiang, Manivakkam J. Shankernarayanan, Robert Scott, Yash Kapoor
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Publication number: 20130308093Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: July 23, 2013Publication date: November 21, 2013Applicant: Novartis AGInventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 8557940Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.Type: GrantFiled: July 29, 2011Date of Patent: October 15, 2013Assignee: Novartis AGInventors: Frank Chang, Robert Scott, Jinyu Huang, Arturo N. Medina, Dawn A. Smith, Laura Ann Sanders, John Dallas Pruitt
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Publication number: 20130250234Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.Type: ApplicationFiled: May 22, 2013Publication date: September 26, 2013Applicant: Novartis AGInventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
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Patent number: 8529057Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: July 29, 2011Date of Patent: September 10, 2013Assignee: Novartis AGInventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo N. Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 8480227Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.Type: GrantFiled: July 29, 2011Date of Patent: July 9, 2013Assignee: Novartis AGInventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
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Patent number: 8440735Abstract: The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.Type: GrantFiled: July 13, 2010Date of Patent: May 14, 2013Assignee: Novartis AGInventors: John Dallas Pruitt, Lynn Cook Winterton, Bernhard Seiferling, Jüergen Vogt, Harald Bothe
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Patent number: 8409599Abstract: The invention provides a cost-effective method for applying a hydrophilic coating onto a silicone hydrogel contact lens based on Fenton chemistry. The hydrophilic coating is covalently attached onto the contact lens at room temperature without UV irradiation. The invention also provides silicone hydrogel contact lenses having a hydrophilic coating obtained according to the method of the invention.Type: GrantFiled: November 2, 2010Date of Patent: April 2, 2013Assignee: Novartis AGInventors: Daqing Wu, Xinming Qian, John Dallas Pruitt
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Publication number: 20120314185Abstract: The invention is related to a method for making a silicone hydrogel contact lens having a nano-textured surface which mimics the surface texture of cornea of human eye. A method of the invention comprises creating a prime coating having nano-textures through controlled imbibition and/or depositions of a reactive polymeric coating material and fixing the nano-textures by crosslinking a hydrophilic polymeric material onto the prime coating to form a crosslinked polymeric coating that perserves the nano-textures of the prime coating and provides a nano-textured surface to the contact lens.Type: ApplicationFiled: June 7, 2012Publication date: December 13, 2012Inventors: R. Erich Bauman, Peter Hagmann, John Dallas Pruitt, Joseph Michael Rappon