Patents by Inventor John Dasilva

John Dasilva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230416376
    Abstract: Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human MET. The bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. The bispecific antigen-binding molecules can exhibit minimal or no MET agonist activity, e.g., as compared to monovalent antigen-binding molecules that comprise only one of the antigen-binding domains of the bispecific molecule, which tend to exert unwanted MET agonist activity.
    Type: Application
    Filed: May 25, 2023
    Publication date: December 28, 2023
    Inventors: Robert Babb, Gang Chen, Christopher Daly, John DaSilva, Douglas MacDonald, Thomas Nittoli
  • Publication number: 20230107172
    Abstract: Provided are one-piece end plates, which end plates can act as current collectors and are useful in electrochemical cell stack assemblies. The end plates can be secured to one another by floating tie rods that exert a pressure on the electrochemical cells disposed between the end plates.
    Type: Application
    Filed: October 1, 2021
    Publication date: April 6, 2023
    Inventors: Steven John DaSilva, Curtis S. Warrington, Andrew Joseph Melough
  • Patent number: 11521735
    Abstract: Aspects and features of this disclosure relate to delivering individualized mental health therapies via networked computing devices. A mental-health-treatment-delivery server outputs a module with video content in connection with a mental health treatment protocol for a user. The mental-health-treatment-delivery server outputs a request for the user to respond to a question or to stimuli. The mental-health-treatment-delivery server receives a response from the user to the question or the stimuli. The mental-health-treatment-delivery server compares the response to stored data to determine information to present to the user. The mental-health-treatment-delivery server receives a command from the server device to present the information to the user. The mental-health-treatment-delivery server outputs the information to an interface of the user device.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: December 6, 2022
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Michael J. Hasselberg, Wendy Cross, Matthew Brown, David John Mitten, Christopher John Dasilva
  • Publication number: 20220049001
    Abstract: Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human MET. The bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. The bispecific antigen-binding molecules can exhibit minimal or no MET agonist activity, e.g., as compared to monovalent antigen-binding molecules that comprise only one of the antigen-binding domains of the bispecific molecule, which tend to exert unwanted MET agonist activity.
    Type: Application
    Filed: August 25, 2021
    Publication date: February 17, 2022
    Inventors: Robert Babb, Gang Chen, Christopher Daly, John DaSilva, Douglas MacDonald, Thomas Nittoli
  • Patent number: 11142578
    Abstract: Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human MET. The bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. The bispecific antigen-binding molecules can exhibit minimal or no MET agonist activity, e.g., as compared to monovalent antigen-binding molecules that comprise only one of the antigen-binding domains of the bispecific molecule, which tend to exert unwanted MET agonist activity.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: October 12, 2021
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Robert Babb, Gang Chen, Christopher Daly, John DaSilva, Douglas MacDonald, Thomas Nittoli
  • Publication number: 20200402642
    Abstract: Aspects and features of this disclosure relate to delivering individualized mental health therapies via networked computing devices. A mental-health-treatment-delivery server outputs a module with video content in connection with a mental health treatment protocol for a user. The mental-health-treatment-delivery server outputs a request for the user to respond to a question or to stimuli. The mental-health-treatment-delivery server receives a response from the user to the question or the stimuli. The mental-health-treatment-delivery server compares the response to stored data to determine information to present to the user. The mental-health-treatment-delivery server receives a command from the server device to present the information to the user. The mental-health-treatment-delivery server outputs the information to an interface of the user device.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 24, 2020
    Applicant: University of Rochester
    Inventors: Michael J. Hasselberg, Wendy Cross, Matthew Brown, David John Mitten, Christopher John Dasilva
  • Publication number: 20180134794
    Abstract: Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human MET. The bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. The bispecific antigen-binding molecules can exhibit minimal or no MET agonist activity, e.g., as compared to monovalent antigen-binding molecules that comprise only one of the antigen-binding domains of the bispecific molecule, which tend to exert unwanted MET agonist activity.
    Type: Application
    Filed: November 15, 2017
    Publication date: May 17, 2018
    Inventors: Robert Babb, Gang Chen, Christopher Daly, John DaSilva, Douglas MacDonald
  • Patent number: 8248263
    Abstract: A system to improve safety of workers who are in proximity to mobile machines includes a machine mountable radio-frequency identification reader that wirelessly monitors radio-frequency identification tags worn by workers moving relative to and in proximity to a mobile machine when the reader is mounted on the machine. The reader includes a processor and an antenna front-end which is switchable between an omni-directional antenna or at least one directional antenna. The omni-directional antenna is mountable so as to monitor a machine circumference completely around the mobile machine. Each directional antenna is mountable so as to monitor only either a front or a back of the mobile machine relative to the machine's direction of motion.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: August 21, 2012
    Assignees: PSST Mobile Equipment
    Inventors: Richard Clayton Shervey, John Dasilva, Ahmad Chamseddine, Peter Haubrich
  • Patent number: 8115650
    Abstract: Disclosed is a method and apparatus for selectively immobilizing equipment to ensure the safety of a proximate worker. The apparatus comprises an article of clothing wearable by the proximate worker, a sensor and a stopping means for stopping the movement of a portion of the equipment in response to the sensing. The article of clothing has a RFID tag having an antenna distributed about the article so as to substantially surround a worker wearing the article of clothing. The sensor senses the proximity of the RFID tag to a portion of the equipment. The method comprises sensing the proximity of the RFID tag to a portion of the equipment and stopping the movement of a portion of the equipment in response to the sensing.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: February 14, 2012
    Inventors: John Dasilva, Richard Clayton Shervey
  • Publication number: 20100289662
    Abstract: A system to improve safety of workers who are in proximity to mobile machines includes a machine mountable radio-frequency identification reader that wirelessly monitors radio-frequency identification tags worn by workers moving relative to and in proximity to a mobile machine when the reader is mounted on the machine. The reader includes a processor and an antenna front-end which is switchable between an omni-directional antenna or at least one directional antenna. The omni-directional antenna is mountable so as to monitor a machine circumference completely around the mobile machine. Each directional antenna is mountable so as to monitor only either a front or a back of the mobile machine relative to the machines direction of motion.
    Type: Application
    Filed: January 9, 2009
    Publication date: November 18, 2010
    Inventors: John Dasilva, Ahmad Chamseddine, Peter Haubrich
  • Publication number: 20090219160
    Abstract: A person-overboard monitoring and alarm system, includes an RFID tag worn by a user; an array of directional antennas for mounting around a perimeter of a boat hull, below and substantially parallel with a gunnel of the boat so as to be arrayed substantially above a water line of the boat and so as to provide a corresponding array of substantially distinct and independent detection zones which are substantially only directed outwardly of the boat, a transceiver cooperating with said array of antennas for detecting the presence of a tag in any one of said detection zones, a processor cooperating with said transceiver for receiving signals from said transceiver upon detection of said tag in said any one of said detection zones and determining which of said detection zones contain said tag, and wherein said processor is adapted to output an alarm trigger signal to an alarm upon said detection, whereby said antenna and said transceiver substantially only detects said tag when located over-board from the boat.
    Type: Application
    Filed: February 11, 2009
    Publication date: September 3, 2009
    Inventors: Richard Clayton Shervey, John DaSilva
  • Publication number: 20080018472
    Abstract: Disclosed is a method and apparatus for selectively immobilizing equipment to ensure the safety of a proximate worker. The apparatus comprises an article of clothing wearable by the proximate worker, a sensor and a stopping means for stopping the movement of a portion of the equipment in response to the sensing. The article of clothing has a RFID tag having an antenna distributed about the article so as to substantially surround a worker wearing the article of clothing. The sensor senses the proximity of the RFID tag to a portion of the equipment. The method comprises sensing the proximity of the RFID tag to a portion of the equipment and stopping the movement of a portion of the equipment in response to the sensing.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 24, 2008
    Inventors: John Dasilva, Richard Shervey