Abstract: A CPAP system includes a flow generator (10), a patient interface (50), an air delivery conduit (20) that interconnects the flow generator and the patient interface, wherein the air delivery conduit has an internal diameter of less than 19 mm. Preferably the air delivery conduit has an internal diameter of between about 10 mm and about 18 mm. The CPAP system may also include a controller for compensating for pressure swings and/or increased impedance within the system. Preferably the blower includes a low inertia blower.

Abstract: Systems, methods and apparatuses to log memory errors in memory devices that can perform wear leveling based on physical addresses used in the memory devices to address select memory cells. For example, a controller of a memory sub-system communicates with a memory device installed in the memory sub-system to access memory cells in the memory device. During the communication to access memory cells in the memory device, the controller can determine a memory error at a first address. If the controller transmits the first address to the memory device for memory access at the time of the memory error, the memory device converts the first address to a second address to perform the memory access. The controller can be configured to determine the second address and record, in an error log, the memory error in association with the second address.

Abstract: Provided nucleic acid-based expression construct for the target cell-specific production of a therapeutic protein, such as a pro-apoptotic protein, within a target cell, including a target cell that is associated with aging, disease, or other condition, in particular a target cell that is a senescent cell or a cancer cell.

Abstract: A respiratory disease analytics system provides respiratory disease risk reports to a patient, provider, or third-party entity describing a patient's risk of experiencing a medication usage event given data in a geographic region. Regional data, including air pollutant conditions, weather conditions, demographic information, built environment factors, and regional health conditions for a geographic region are accessed from other sources and assigned based on event data recorded during a medicament usage event, as collected by sensors associated with the patient's medicament device/s. The regional data is assigned to medicament usage events occurring within a period of time. The assigned regional data is analyzed to determine an expected number of medication usage events for the geographic region occurring over the period of time.

Abstract: A mounting device includes a first arm, a second arm positioned parallel to the first arm, and a top plate coupled to the first arm and the second arm. The top plate includes a center portion, a first coupling panel formed at a 90 degree angle with respect to a surface of the center portion, and a second coupling panel formed at a 90 degree angle with respect to a surface of the center portion. The second coupling panel is located at a side of the center portion opposite the first coupling panel.

Abstract: This disclosure relates to a graft preparation station and methods for repairing bone defects. The station described herein may be utilized for dimensioning a graft prior to positioning the shaped graft at a surgical site.

Abstract: An automated security assessment service of a service provider network may identify, and notify a customer of, misconfigured VM instances that can be access (e.g., via the Internet). A scanner tool may call an automated reasoning service to identify any VM instances of a customer that can be accessed, and may receive information from the automated reasoning service that is usable to exchange packets with those identified instances. The scanner tool can use the information to send requests to the identified instances. After receiving responses from the identified instances, the scanner tool can store, in storage of a network-based storage service, and in association with a customer account of the customer, encrypted data about the results of the scan (e.g., any VM instances that are vulnerable to attackers), and this encrypted data is thereby accessible to the customer with proper decrypt permissions.

Abstract: Apparatus and associated methods relate to a unitary ring gear-flange body (URGFB). In an illustrative example, the flange body may be spin-formed and may, for example, include a riser body extending substantially parallel to a longitudinal axis and a flange extending substantially radially outward from the riser body. To the riser body may, for example, be welded a ring gear to form a unitary assembly, the ring gear having an axis of revolution aligned with the longitudinal axis. A continuous coating may, for example, be applied to at least a selected portion of a surface of the unitary assembly. Various embodiments may advantageously provide a cost-efficient, weight-efficient, and/or time-efficient unitary body which may, for example, be coupled to machinery to provide a shaftless torque-transmitter.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The invention relates to the use of disconnection agents before, or together with, toxic agents for the treatment of solid tumours.

Abstract: Connection settings used by a mobile device to connect to a packet data network, e.g. the internet, are stored in a subscriber identity module (SIM) card. This enables connection settings to be pre-loaded on a SIM card, allowing a mobile device to immediately connect to the internet without manual configuration. The mobile device's connection settings may also be updated by a mobile network operator via an over the air profile update. For example, the operator may supply a device with connection settings the first time it connects to the network. Connection settings may be stored in one or more files within the SIM profile, and may be updated via a remote file management operation. Embedded-SIM (eSIM) profiles may also store connection settings in profile metadata, which may be updated via a metadata update operation.

Abstract: This description relates to insight into the asthma management habits of a patient or a plurality of patients. The provided information includes records of rescue medication usage events, records of controller medication events, and overall evaluations of a patients disease management. Users of the application may include both patients who may use the information to monitor their own habits or providers who may use the information to monitor patients or improve a patient's existing medication regimen.

Abstract: Provided is a firearm cartridge chamber with a relief feature that traps a portion of a cartridge case within the cartridge chamber when fired. The relief feature causes the cartridge case to deform within the chamber, wherein it optionally separates into a forward section and a rearward section. The deformed case remains trapped after firing, preventing extraction of the fired case and the chambering or firing of any subsequent cartridges, thereby causing a firearm malfunction. The cartridge chamber can distinguish between higher and lower pressure cartridges by allowing for normal firing and function with blank training ammunition while also facilitating localized deformation of the cartridge case when firing standard ammunition that includes one or more projectiles. The inventive chamber prevents more than one higher pressure round from firing while allowing lower pressure or training rounds to fire without limitation, which aids in enhanced safety during training exercises.

Abstract: A method for categorizing a substrate subject to a semiconductor manufacturing process including multiple operations, the method including: obtaining values of functional indicators derived from data generated during one or more of the multiple operations on the substrate, the functional indicators characterizing at least one operation; applying a decision model including one or more threshold values to the values of the functional indicators to obtain one or more categorical indicators; and assigning a category to the substrate based on the one or more categorical indicators.

Abstract: A low-profile coupled inductor is disclosed to provide compact and high performance magnetic coupling. The low-profile coupled inductor has an asymmetrical geometry, having a pair of complementary ferrite cores supporting a pair of conducting strips in an alternating serpentine pattern. One or more core gaps exist between the cores to create a strong flux coupling between adjacent magnetic fields of either conducting strip. The alternating serpentine conductors and core gaps serve to increase energy transfer between the magnetic fields and improve the overall power density of the low-profile coupled inductor.

Abstract: A trisamide compound has the structure of Formula (I) in which R1, R2, and R3 are independently selected from the group consisting of alkyl groups. A polymer composition comprises a trisamide compound of Formula (I) and a polyolefin polymer. The polymer compositions containing a trisamide compound of Formula (I) exhibit very low haze levels and minimal extraction of the trisamide compound.

Abstract: This disclosure relates to surgical devices and methods for repairing bone defects. The defect indicators disclosed herein may be utilized to indicate a precise location of the defect associated with an articular surface of a joint.

Abstract: The disclosure describes a scalable, risk-based authentication system including a plurality of fraud monitoring engines configured to: analyze user data and organization data, and generate a set of risk factors based on the user data and the enterprise data; a risk aggregator in communication with the plurality of fraud monitoring engines configured to: receive the set of risk factors, and transform the set of risk factors into risk indicators; and an authentication engine configured to: receive the risk indicators from the risk aggregator, and generate an authentication plan for a requested activity based on the risk indicators and the requested activity.

Abstract: An exercise apparatus for strengthening the hips that includes a belt adapted for being tightly secured around the hip area of a user and a resistance band attached to the belt at a position wherein the resistance band resides proximate the hips. An anchor is provided for attaching a distal end of the resistance band to a support generally at a level with the hips whereby rotating the hips applies resistance to the hips providing strengthening resistance to the hips. A method of using the apparatus is disclosed.