Abstract: Described are lantibiotic-based compounds, pharmaceutical compositions comprising the same and use of the compounds and said compositions, for the treatment of microbial infection, for example Clostridium difficile or Micrococcus luteus infection. The lantibiotic-based compounds have antimicrobial activity and in comparison to one or more of actagardine, actagardine B, deoxyactagardine B and deoxyactagardine have retained activity or improved activity.

Abstract: Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is —NHC(O)—, —C(O)—, —OC(O)—, —CH2— or —SO2—; R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkyl). and the alkyl or cycloalkyl bears one, two or three hydroxyl groups, or a —NR6R7 group, or one —NR6R7 group and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description.

Abstract: Soybean plants comprising event SYHT04R, methods of detecting and using the same, and soybean plants comprising a heterologous insert at the same site as SYHT04R.

Abstract: A method of thermally treating tissue during a surgical procedure where a surgical access device, including a body member having walls with at least one conduit therein, is inserted into the patient. A chilled fluid is circulated through the at least one conduit such that the tissue that is located proximate the body member is cooled. Alternatively, the body member may be constructed from a highly thermally conductive material such that heat energy is transmitted through the body from the tissue located proximate the body member and into a heat sink. The surgical device may include a first or second blade portions constructed from an inner and an outer shell having walls. Ribs located on the inner shell sealingly coupled to the inner wall of the outer shell to create the at least one conduit within the walls of the blade portion.

Abstract: A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds selected from the group consisting of mersacidin, actagardine, plantaricin, planosporicin, ruminococcin, antibiotic 10789, michiganin and haloduracin, and derivatives and variants thereof.

Abstract: A hinge set (and associated methodology and resultant hung doors or windows) where the leaf of each hinge sleeved component is, or is to be, leafwise received in, and is, or to be, screwed into, a different cavity, yet allowing aligned sleeve meshing for pin insertion. Its use allows the leaf to be largely concealed even when the doors or windows are open.

Abstract: Characterization of the biosynthetic gene cluster for the lantibiotic antibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterized biosynthetic gene clusters, is described.

Abstract: Described are lantibiotic-based compounds, pharmaceutical compositions comprising the same and use of the compounds and said compositions, for the treatment of microbial infection, for example Clostridium difficile or Micrococcus luteus infection. The lantibiotic-based compounds have antimicrobial activity and in comparison to one or more of actagardine, actagardine B, deoxyactagardine B and deoxyactagardine have retained activity or improved activity.

Abstract: Adjustment of stresses within a threaded connection having radial thread interference is taught by forming the box and pin threads on different axial pitches before assembly, so as to result in a preferred stress pattern after assembly. Also taught, is how to shape thread forms so as to avoid galling while connecting or disconnecting the box and pin.

Abstract: A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds selected from the group consisting of mersacidin, actagardine, plantaricin, planosporicin, ruminococcin, antibiotic 10789, michiganin and haloduracin, and derivatives and variants thereof.

Abstract: A flat-hose assembly has a proximal end and a distal end adapted for use with a negative pressure wound drainage system. The flat-hose assembly comprises a top layer, a bottom layer, and a filter layer. The bottom layer forms an opening at the distal end of the flat-hose assembly to allow exudates of a wound to flow into the flat-hose assembly. The filter layer is disposed between the top layer and the bottom layer. The top and bottom layer form a seal area along a periphery of the top layer and the bottom layer to seal the filter layer therebetween.

Abstract: This invention relates to characterisation of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterised biosynthetic gene clusters.

Abstract: A portable closed wound drainage system that uses a pouch shaped dressing which is inserted into a wound. At least a portion of the outer surface of the pouch 1 is porous to allow exudates to enter. Exudates are removed from the pouch by flexible tubing which is secured inside the pouch at one end, and secured at the other end to a portable drain/suction unit. The pouch contains porous material, and may optionally contain beads and fillers which are antibacterial in nature. The tubing can have a single or multi-lumen structure with perforations in the side walls of the end of the tube that is inserted in the pouch to allow body fluids to enter laterally. The portable drain/suction unit is preferably a portable battery powered device. The pouch and the tube are sealed by a flexible sealing material which is applied to the outer surface of the skin around the periphery of the pouch and the tubing as it exits the pouch.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.

Abstract: Characterization of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine are described.

Abstract: A hinge set (and associated methodology and resultant hung doors or windows) where the leaf of each hinge sleeved component is, or is to be, leafwise received in, and is, or to be, screwed into, a different cavity, yet allowing aligned sleeve meshing for pin insertion. Its use allows the leaf to be largely concealed even when the doors or windows are open.

Abstract: A device for spinal stabilization includes bone anchors, a metal cord, and a spacer. The materials of the cord and spacer are chosen to allow the physician to customize the stiffness of the stabilization device based on a particular patient's needs. Each bone anchor has a clamping mechanism for securing the cord to the bone anchor. In an assembled and implanted state of the device, the spacer is positioned between two neighboring bone anchors, thereby impeding the motion of the bone anchors toward each other; the cord is clamped to the bone anchors, thereby impeding the motion of the bone anchors away from each other. By increasing or decreasing the tension in the cord during implantation, the physician can create a stabilization device that is either relatively stiff or relatively flexible to accommodate the specific needs of the patient.

Abstract: A portable closed wound drainage system that uses a pouch shaped dressing which is inserted into a wound. At least a portion of the outer surface of the pouch is porous to allow exudates to enter. Exudates are removed from the pouch by flexible tubing which is secured inside the pouch at one end and secured at the other end to a portable drain/suction unit. The pouch contains porous material. The tubing can have a single or multi-lumen structure. The pouch and the tube are sealed by a flexible sealing material which is applied to the outer surface of the skin. A cosmetic cover sheet is attached to the patient's skin over the closed wound drainage system.

Abstract: Devices systems and methods are provided for providing a deterministic remote interface unit (RIU) based on a finite state machine. The RIU emulator uses a sequence controller that is configured to receive a synchronization input and to execute a fixed list of unconditional commands in an invariable order of execution based solely upon the synchronization input. The RIU emulator also uses pre-defined or pre-certified data structures that are specific to one or more interface devices to successfully execute the at least one unconditional command of the plurality when encountered in the invariable order. As such, peripheral devices may be added, removed or updated without recertification by merely inserting pre-certified data structures into memory or deleting them.

Abstract: Characterization of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine are described.