Patents by Inventor John De Koning

John De Koning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs)
    Patent number: 7906491
    Abstract: The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: March 15, 2011
    Assignee: Univisitair Medisch Centrum Utrecht
    Inventors: John De Koning, Anne Christensen, Frank Schwede, Hans Gottfired Genieser, Stein Doskeland, Johannes Bos
  • Compounds for modulating the activity of exchange proteins directly activated by camp (epacs)
    Publication number: 20060100166
    Abstract: The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of humans and/or animals.
    Type: Application
    Filed: June 10, 2003
    Publication date: May 11, 2006
    Applicant: KYLIX B.V.
    Inventors: John De Koning, Anne Christensen, Frank Schwede, Hans Genieser, Stein Doskeland, Johannes Bos