Abstract: Method, system and apparatus (10) for capturing eye/pupil movement(s). Wearable apparatus (10) includes image capture means (12,18), a light source (16) to illuminate the eye(s). Video recordings can be stored in memory (20) and/or transmitted to a remote location. The apparatus (10) can include on-board image processing. Pupil shape and/or position can be determined e.g. from glints (28). Direction and speed of eye motion can be determined. Head movement (50) and eye motion (52) measurements can be obtained. Measurement by head movement sensors (32), body sensors (34) and/or environment sensors (38) (e.g. gravity) can be factored in to an assessment of the user's condition.

Abstract: The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.

Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.

Abstract: The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.

Abstract: The present invention provides prodrug modifications for chemotherapeutic drugs that allow activation in the cytosol.

Abstract: In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The obstruction index is used to differentiate normal and obstructed breathing. The obstruction index is based upon different weighting factors applied to sections of the airflow signal thereby improving sensitivity to various types of respiration obstructions.

Abstract: In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The obstruction index is used to differentiate normal and obstructed breathing. The obstruction index is based upon different weighting factors applied to sections of the airflow signal thereby improving sensitivity to various types of respiration obstructions.

Abstract: In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The obstruction index is used to differentiate normal and obstructed breathing. The obstruction index is based upon different weighting factors applied to sections of the airflow signal thereby improving sensitivity to various types of respiration obstructions.

Abstract: A method and CPAP apparatus characterizes different mask systems, e.g., masks and hoses. The CPAP apparatus can be calibrated for different mask systems and hoses by including sensors that measure flow and pressure at a flow generator of the apparatus. When the generator is fitted to a new mask system, or any changes are made to an existing one, a method calibrates the generator for the mask system. The method includes determining air flow characteristics using flow measurements from a first test period when flow through the mask system is open, measuring or estimating pressure in the mask system during a second test period when flow through the mask system is blocked and determining air flow characteristics of the diffuser of the mask system using the air flow characteristics of the air delivery hose determined during the first period and the pressure measurements made during the second period.

Abstract: A method and a CPAP apparatus for characterizing different mask systems, e.g., masks and hoses, are provided. The apparatus can be calibrated for different mask systems and hoses by including sensors for measuring flow and pressure at a flow generator of the apparatus. When the flow generator is fitted to a new system, or changes are made to an existing system, mask or patient interface, and/or hose, a method of calibrating the flow generator is provided. The method includes determining air flow characteristics of the hose using flow measurements made during a first test period when flow through the system is open, measuring or estimating pressure in the system during a second test period when flow through the system is blocked, and determining air flow characteristics of the diffuser using the air first test period flow characteristics of the air delivery hose and the second test period pressure measurements.

Abstract: A method and a CPAP apparatus for characterizing mask systems provided. The CPAP apparatus can be calibrated by including sensors configured to measure flow and pressure. When the flow generator is fitted to a new or changed mask system, a method for calibrating the flow generator for the new or changed mask system. The method includes determining air flow characteristics using flow measurements made during a first test period when the flow through the mask system is open, measuring or estimating pressure in the mask system during a second test period when the flow through the mask system is blocked and determining air flow characteristics of the diffuser of the mask system using the air flow characteristics of the air delivery hose determined during the first test period and the pressure measurements made during the second test period.

Abstract: A method and a CPAP apparatus for characterizing different mask systems, e.g., masks and hoses, are provided. The apparatus can be calibrated for different mask systems and hoses by including sensors for measuring flow and pressure at a flow generator of the apparatus. When the flow generator is fitted to a new system, or changes are made to an existing system, mask or patient interface, and/or hose, a method of calibrating the flow generator is provided. The method includes determining air flow characteristics of the hose using flow measurements made during a first test period when flow through the system is open, measuring or estimating pressure in the system during a second test period when flow through the system is blocked, and determining air flow characteristics of the diffuser using the air first test period flow characteristics of the air delivery hose and the second test period pressure measurements.

Abstract: A method and a CPAP apparatus for characterizing a plurality of different mask systems, e.g., masks and hoses, are provided. The CPAP apparatus can be calibrated for different mask systems and hoses by including sensors configured to measure flow and pressure at a flow generator of the CPAP apparatus. When the flow generator is fitted to a new mask system, or any changes are made to an existing mask system, mask or patient interface and/or hose, a method for calibrating the flow generator for the new mask system, mask and/or hose is provided.

Abstract: A method and a CPAP apparatus for characterizing a plurality of different mask systems, e.g., masks and hoses, are provided. The CPAP apparatus can be calibrated for different mask systems and hoses by including sensors configured to measure flow and pressure at a flow generator of the CPAP apparatus. When the flow generator is fitted to a new mask system, or any changes are made to an existing mask system, mask or patient interface and/or hose, a method for calibrating the flow generator for the new mask system, mask and/or hose is provided.

Abstract: A logic arrangement, method and computer program for reducing incidence of errors in a redundant path system during a process of attachment of a device to a running subsystem, comprises a control component for encapsulating the process of attachment of a device to a running subsystem; a disabling component for disabling a path interface; a testing component for testing for the presence of a usable data path across at least one further path interface; and an enabling component for enabling the at least one further path interface to accept communication with the device responsive to a positive outcome from the testing component; wherein the control component is adapted to permit operation after attachment of the device only if full redundancy is retained. A re-enabling component may re-enable any path interface or further path interface.

Abstract: An apparatus for supplying breathable gas includes a main housing, a sub-housing removably connected to the main housing, and a vent valve assembly provided to the sub-housing. The sub-housing has a gas flow path between a gas inlet and a gas outlet. The vent valve assembly includes a gas venting conduit in fluid communication with the gas flow path. The gas venting conduit is adapted to be selectively restricted by a cam abutting an exterior of the gas venting conduit, whereby a position of the cam is variable to vary gas passing through the gas venting conduit which varies a flow rate of gas leaving the gas outlet.

Abstract: A sub-housing received within a housing of an apparatus for supplying breathable gas, includes a gas flow path between a gas inlet and a gas outlet and an impeller in fluid communication between the gas inlet and the gas outlet. The impeller is structured and configured to be releasably engaged with a shaft associated with an electric motor that is disposed exterior to the housing, whereby rotation of the shaft causes rotation of the impeller.

Abstract: In a stacked system, errors detected at a user application interface of one or more host systems are associated with root cause errors at a stack level below a virtualization layer by detecting an error at a user application interface; identifying an associated root cause error at a lower stack level; creating an error trace entry for the error; associating an error log identifier with the error trace entry; making the combined error log identifier and the error trace entry into an error identifier that is unique within the plurality of host systems in said stacked system; and communicating the error identifier to any requester of a service at a user application interface of one or more host systems when the service must be failed because of the root cause error.

Abstract: A sub-housing received within a housing of an apparatus for supplying breathable gas, includes a gas flow path between a gas inlet and a gas outlet and an impeller in fluid communication between the gas inlet and the gas outlet. The impeller is structured and configured to be releasably engaged with a shaft associated with an electric motor that is disposed exterior to the housing, whereby rotation of the shaft causes rotation of the impeller.

Abstract: In a stacked system, errors detected at a user application interface of one or more host systems are associated with root cause errors at a stack level below a virtualization layer by detecting an error at a user application interface; identifying an associated root cause error at a lower stack level; creating an error trace entry for the error; associating an error log identifier with the error trace entry; making the combined error log identifier and the error trace entry into an error identifier that is unique within the plurality of host systems in said stacked system; and communicating the error identifier to any requester of a service at a user application interface of one or more host systems when the service must be failed because of the root cause error.