Abstract: The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.

Abstract: The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.

Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.

Abstract: The present invention provides prodrug modifications for chemotherapeutic drugs that allow activation in the cytosol.

Abstract: The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.

Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.

Abstract: The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.

Abstract: The present invention provides prodrug modifications for chemotherapeutic drugs that allow activation in the cytosol.

Abstract: A touch system using a plurality of infrared (“IR”) transmitters and receivers, and a method of determining with increased resolution the location of a touch between the IR transmitters and receivers using on-axis and off-axis detection are disclosed. The inventive touch system and method use, in conjunction with the on-axis and off-axis detection, a coarse and fine sweep of the transmitters and receivers to increase the resolution of identified touch location. The method of determining a touch location involves selection and activation of particular off-axis infrared transmitter and receiver pairs determined from a triangulation interdependence between the x and y coordinates. The increased resolution of the identified touch location is achievable using the inventive system and method without the need for an increased number of IR transmitters and receivers and without the need for higher speed processing capability.

Abstract: A touch system using a plurality of infrared (“IR”) transmitters and receivers, and a method of determining with increased resolution the location of a touch between the IR transmitters and receivers using on-axis and off-axis detection are disclosed. The inventive touch system and method use, in conjunction with the on-axis and off-axis detection, a coarse and fine sweep of the transmitters and receivers to increase the resolution of identified touch location. The method of determining a touch location involves selection and activation of particular off-axis infrared transmitter and receiver pairs determined from a triangulation interdependence between the x and y coordinates. The increased resolution of the identified touch location is achievable using the inventive system and method without the need for an increased number of IR transmitters and receivers and without the need for higher speed processing capability.

Abstract: A system and method for handling audio input/output data translates audio message in a first format from an audio application resident in a virtual machine to an audio voice in a second format which may have no exact match for the original audio message. The invention is used for audio applications which directly write to a particular hardware register of a particular audio card to communicate with an audio card which operates according to completely different principles. The translating program intercepts the audio message written in the first format including a first plurality of audio parameters, compares the audio parameters to those corresponding to a table of audio voices and selects the audio voice which corresponds to a match of the audio parameters in the audio message. If there is no exact match in the table, a variety of techniques are provided to calculate the closest or at least an acceptable audio voice for the original audio message.

Abstract: Tube working apparatus is provided comprising a mandrel having a die thereon over which a tube to be worked can be positioned. The die is adapted to cooperate with a tool externally of the tube to work the tube. Feed means is provided for effecting relative movement between the mandrel and the tube whereby the tube is progressively withdrawn from the mandrel as working proceeds.