Abstract: The invention relates to a suspension (20) in accordance with a first embodiment of the invention that permits reducing the number of load cells (14) incorporated in a suspension (20) of a vehicle or a trailer such as a semi-trailer to be towed by a towing vehicle. In accordance with a particular embodiment of the invention reduction of the number of load cells (14) is accomplished through the use of pivot joints (34) (that pivotally attach the suspension rockers (32) to the hangers 26) of reduced friction. In particular embodiments of the invention, the number and location of the low and lower friction pivot joints (34) may be chosen such as to increase the accuracy of measurement of the load cells. The invention also relates to load cell pins (62) for defining the pivot joint (34) that pivotally attaches rockers (32) to hangers (26) of the suspension (20).

Abstract: A support arrangement having an activation mechanism to control the movement of wheels is provided. The support arrangement includes a platform, a chassis attached to the platform, a pair of wheel assemblies movably coupled to the chassis, and the activation mechanism. The pair of wheel assemblies are operable between a first state and a second state. The activation mechanism includes a track having a first stable position and a second stable position spaced along a length of the track, and a pin configured to travel along the track. Wheels are in the first state when the pin is in the first stable position and are in the second state when the pin is in the second stable position.

Abstract: A support arrangement having an activation mechanism to control the movement of wheels is provided. The support arrangement includes a platform, a chassis attached to the platform, a pair of wheel assemblies movably coupled to the chassis, and the activation mechanism. The pair of wheel assemblies are operable between a first state and a second state. The activation mechanism includes a track having a first stable position and a second stable position spaced along a length of the track, and a pin configured to travel along the track. Wheels are in the first state when the pin is in the first stable position and are in the second state when the pin is in the second stable position.

Abstract: The present invention relates to a method and system for delivering messages, such as advertising messages. Printed labels are provided on drinks container lids, such as takeaway coffee container lids. Providing printed labels has the advantage that the lid does not need to be changed to provide a different message. Only the printed label has to be changed. To facilitate placement of the printed labels on the lids, the present invention also provides a labelling machine which includes delivery apparatus for delivering lids to a labelling position. The delivery apparatus includes a picker arrangement arranged to pick individual lids from a magazine and place them on a conveyer for delivery to the labelling point. It also includes a stacker apparatus for stacking the lids into a magazine for ease of distribution.

Abstract: The present invention relates to a method and system for delivering messages, such as advertising messages. Printed labels are provided on drinks container lids, such as takeaway coffee container lids. Providing printed labels has the advantage that the lid does not need to be changed to provide a different message. Only the printed label has to be changed. To facilitate placement of the printed labels on the lids, the present invention also provides a labelling machine which includes delivery apparatus for delivering lids to a labelling position. The delivery apparatus includes a picker arrangement arranged to pick individual lids from a magazine and place them on a conveyer for delivery to the labelling point. It also includes a stacker apparatus for stacking the lids into a magazine for ease of distribution.

Abstract: Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.

Abstract: The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.

Abstract: The present invention relates to methods and devices for intradermal delivery of substances, preferably therapeutic substances by targeting the substance to the intradermal compartment of a subject's skin. Substances delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods including intramuscular, and subcutaneous delivery. The present invention provides benefits and improvements over conventional drug delivery methods including but not limited to, improved pharmacokinetics and bioavailability.

Abstract: The present invention relates to methods and devices for intradermal delivery of substances, preferably therapeutic substances by targeting the substance to the intradermal compartment of a subject's skin. Substances delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods including intramuscular, and subcutaneous delivery. The present invention provides benefits and improvements over conventional drug delivery methods including but not limited to, improved pharmacokinetics and bioavailability.

Abstract: Methods for amplifying nucleic acid in a sample including providing the sample with a set of primers to enable synthesis of at least one nucleic acid strand complementary to at least part of the nucleic acid, wherein the set of primers comprises between 3-8 random bases, preferably clustered near the 3? end of each primer in said set of primers. The methods of the invention are useful, for example, for determining whether samples derived from humans, mammals, poultry, or fish comprise nucleic acid of a pathogen. The methods are further suited for typing the pathogen and typing particular variants of said pathogen. The methods are also suited for the elucidation of the gene expression profile or genetic profile of cells.

Abstract: The present invention relates to methods and devices for intradermal delivery of substances, preferably therapeutic substances by targeting the substance to the intradermal compartment of a subject's skin. Substances delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods including intramuscular, and subcutaneous delivery. The present invention provides benefits and improvements over conventional drug delivery methods including but not limited to, improved pharmacokinetics and bioavailability.

Abstract: A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: Methods for amplifying nucleic acid in a sample comprising providing the sample with a set of primers to enable synthesis of at least one nucleic acid strand complementary to at least part of the nucleic acid, wherein the set of primers comprises between 3-8 random bases, preferably clustered near the 3′ end of each primer in said set of primers. The methods of the invention are useful, for example, for determining whether samples derived from humans, mammals, poultry, or fish comprise nucleic acid of a pathogen. The methods are further suited for typing the pathogen and typing particular variants of said pathogen. The methods are also suited for the elucidation of the gene expression profile or genetic profile of cells.

Abstract: Methods for amplifying nucleic acid in a sample comprising providing the sample with a set of primers to enable synthesis of at least one nucleic acid strand complementary to at least part of the nucleic acid, wherein the set of primers comprises between 3-8 random bases, preferably clustered near the 3′ end of each primer in said set of primers. The methods of the invention are useful, for example, for determining whether samples derived from humans, mammals, poultry, or fish comprise nucleic acid of a pathogen. The methods are further suited for typing the pathogen and typing particular variants of said pathogen. The methods are also suited for the elucidation of the gene expression profile or genetic profile of cells.