Abstract: A portable pill crushing device includes a housing having a base, a motor disposed in the housing, a battery for supplying electrical power to the motor, and a series of rotatably mounted rollers connected to the motor. A pressure plate is attached to the housing and is movable between a closed position in which a crushing chamber is defined between a first surface of the pressure plate and the outer surfaces of the rollers, and an open position in which the pressure plate can be used to provide a manual pre-crushing operation to reduce large pills to an acceptable size range. The housing has a vacuum lock system in its base for anchoring the crushing device to a smooth surface. Plastic enclosures are provided for encasing the pills to prevent direct contact of the pills with the rollers and the pressure plate to avoid contamination.