Patents by Inventor John Desjardins
John Desjardins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969475Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DUX4. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.Type: GrantFiled: October 26, 2023Date of Patent: April 30, 2024Assignee: Dyne Therapeutics, Inc.Inventors: Romesh R. Subramanian, Mohammed T. Qatanani, Timothy Weeden, Cody A. Desjardins, Brendan Quinn, John Najim
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Publication number: 20240125251Abstract: An energy storage system (TES) converts variable renewable electricity (VRE) to continuous heat at over 900° C. Intermittent electrical energy heats a solid medium. Heat from the solid medium is delivered continuously on demand. Heat delivery via flowing gas establishes a thermocline which maintains high outlet temperature throughout discharge. The delivered heat which may be used for processes including power generation and cogeneration. In one application, thermal energy storage systems are used to improve efficiency and reduce carbon emissions associated with processing materials or other industrial applications.Type: ApplicationFiled: December 22, 2023Publication date: April 18, 2024Inventors: John Setel O'DONNELL, Yusef Desjardins FERHANI
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Publication number: 20240110184Abstract: Aspects of the disclosure relate to oligonucleotides (e.g., RNAi oligonucleotides such as siRNAs) designed to target DUX4 RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease (e.g., FSHD).Type: ApplicationFiled: December 30, 2021Publication date: April 4, 2024Applicant: Dyne Therapeutics, Inc.Inventors: Duncan Brown, Nelson Hsia, Romesh R. Subramanian, Mohammed T. Qatanani, Timothy Weeden, Cody A. Desjardins, Brendan Quinn, John Najim
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Patent number: 11931421Abstract: Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes comprising an oligonucleotide (e.g., useful for targeting DMPK) covalently linked to an antibody (e.g., anti-TfR1 antibody).Type: GrantFiled: April 19, 2023Date of Patent: March 19, 2024Assignee: Dyne Therapeutics, Inc.Inventors: Scott Hilderbrand, Timothy Weeden, John Najim, Stefano Zanotti, Romesh R. Subramanian, Mohammed T. Qatanani, Cody A. Desjardins, Kim Tang, Brendan Quinn
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Patent number: 11920501Abstract: An energy storage system converts variable renewable electricity (VRE) to continuous heat at over 1000° C. Intermittent electrical energy heats a solid medium. Heat from the solid medium is delivered continuously on demand. An array of bricks incorporating internal radiation cavities is directly heated by thermal radiation. The cavities facilitate rapid, uniform heating via reradiation. Heat delivery via flowing gas establishes a thermocline which maintains high outlet temperature throughout discharge. Gas flows through structured pathways within the array, delivering heat which may be used for processes including calcination, hydrogen electrolysis, steam generation, and thermal power generation and cogeneration. Groups of thermal storage arrays may be controlled and operated at high temperatures without thermal runaway via deep-discharge sequencing. Forecast-based control enables continuous, year-round heat supply using current and advance information of weather and VRE availability.Type: GrantFiled: July 17, 2023Date of Patent: March 5, 2024Assignee: Rondo Energy, Inc.Inventors: John Setel O'Donnell, Peter Emery Von Behrens, Chiaki Treynor, Jeremy Quentin Keller, Matthieu Jonemann, Robert Ratz, Yusef Desjardins Ferhani
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Publication number: 20240066140Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DUX4. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.Type: ApplicationFiled: October 26, 2023Publication date: February 29, 2024Applicant: Dyne Therapeutics, Inc.Inventors: Romesh R. Subramanian, Mohammed T. Qatanani, Timothy Weeden, Cody A. Desjardins, Brendan Quinn, John Najim
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Patent number: 11913362Abstract: An energy storage system (TES)converts variable renewable electricity (VRE) to continuous heat at over 1000° C. Intermittent electrical energy heats a solid medium. Heat from the solid medium is delivered continuously on demand. Heat delivery via flowing gas establishes a thermocline which maintains high outlet temperature throughout discharge. The delivered heat which may be used for processes including power generation and cogeneration. In one application, the energy storage system provides higher-temperature heat to a steam cracking furnace system for converting a hydrocarbon feedstock into cracked gas, thereby increasing the efficiency of the temperature control.Type: GrantFiled: June 1, 2023Date of Patent: February 27, 2024Assignee: Rondo Energy, Inc.Inventors: John Setel O'Donnell, Yusef Desjardins Ferhani
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Patent number: 11913361Abstract: An energy storage system (TES) converts variable renewable electricity (VRE) to continuous heat at over 1000° C. Intermittent electrical energy heats a solid medium. Heat from the solid medium is delivered continuously on demand. Heat delivery via flowing gas establishes a thermocline which maintains high outlet temperature throughout discharge. The delivered heat which may be used for processes including power generation and cogeneration. In one application, the TES provides higher-temperature heat through non-combustible fluid to an alumina calcination system used to remove impurities or volatile substances and/or to incur thermal decomposition to a desired product.Type: GrantFiled: May 5, 2023Date of Patent: February 27, 2024Assignee: Rondo Energy, Inc.Inventors: John Setel O'Donnell, Yusef Desjardins Ferhani
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Patent number: 11684307Abstract: Implantable sensors for determining bone health that can be utilized in conjunction with orthopedic implants are described. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant; for instance, to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area; for instance, to monitor the implant area of early stage infection or healing of a fusion procedure.Type: GrantFiled: April 23, 2020Date of Patent: June 27, 2023Assignee: Clemson University Research FoundationInventors: Jeffrey Anker, Caleb Behrend, John Desjardins
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Patent number: 11357281Abstract: A force generator applying a force load against a facemask. A first load cell carrying a first portion of the facemask at an attachment point of the facemask where the facemask is attachable to a helmet. A second load cell carrying a second portion of the facemask at another attachment point of the facemask where the facemask is attachable to a helmet. A first attachment platform carrying the first load cell, wherein the first attachment platform is laterally movable in at least two degrees of freedom. A second attachment platform carrying the second load cell, wherein the second attachment platform is laterally movable in at least two degrees of freedom. The force generator directs the contact plate against the facemask to cause a horizontal deformation of the facemask and a lateral movement of the attachment platforms to allow for repeatable force load testing on a single facemask.Type: GrantFiled: October 18, 2019Date of Patent: June 14, 2022Assignee: CLEMSON UNIVERSITY RESEARCH FOUNDATIONInventors: John DesJardins, Gregory S. Batt, Alexander Bina
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Publication number: 20200275879Abstract: Implantable sensors for determining bone health that can be utilized in conjunction with orthopedic implants are described. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant; for instance, to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area; for instance, to monitor the implant area of early stage infection or healing of a fusion procedure.Type: ApplicationFiled: April 23, 2020Publication date: September 3, 2020Inventors: JEFFREY ANKER, CALEB BEHREND, JOHN DESJARDINS
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Patent number: 10667745Abstract: Implantable sensors for determining bone health are described that can be utilized in conjunction with orthopedic implants. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant for instance to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area, for instance to monitor the implant area of early stage infection or healing of a fusion procedure.Type: GrantFiled: August 12, 2016Date of Patent: June 2, 2020Assignee: Clemson University Research FoundationInventors: Jeffrey Anker, Caleb Behrend, John DesJardins
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Publication number: 20200121018Abstract: A force generator applying a force load against a facemask. A first load cell carrying a first portion of the facemask at an attachment point of the facemask where the facemask is attachable to a helmet. A second load cell carrying a second portion of the facemask at another attachment point of the facemask where the facemask is attachable to a helmet. A first attachment platform carrying the first load cell, wherein the first attachment platform is laterally movable in at least two degrees of freedom. A second attachment platform carrying the second load cell, wherein the second attachment platform is laterally movable in at least two degrees of freedom. The force generator directs the contact plate against the facemask to cause a horizontal deformation of the facemask and a lateral movement of the attachment platforms to allow for repeatable force load testing on a single facemask.Type: ApplicationFiled: October 18, 2019Publication date: April 23, 2020Inventors: John DesJardins, Gregory S. Batt, Alexander Bina
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Patent number: 10244818Abstract: Orthotics and methods for forming orthotics are described. The orthotics can be designed with a patient-specific design and can include variation in hardness across the orthotic so as to satisfy clinical need. An orthotic can be a custom-designed orthotic formed according to an additive manufacturing process such as a 3-D printing methodology. Through utilization of on-site formation methods such as 3-D printing, an orthotic can be designed, formed and fit at the point of care in a much shorter time period than traditional orthotics. The orthotics can include a layer that includes a plurality of cells across the layer. The layer can exhibit variable hardness across the layer through variation in cell void volume and optionally material of formation across the layer.Type: GrantFiled: February 18, 2016Date of Patent: April 2, 2019Assignees: Clemson University Research Foundation, Ability Prosthetics & Orthotics, Inc.Inventors: John DesJardins, Scott Edward Stanley, Breanne Przestrzelski, Timothy C. Pruett, Steve L. Hoeffner, Brian Daryl Kaluf
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Publication number: 20180228428Abstract: Implantable sensors for determining bone health are described that can be utilized in conjunction with orthopedic implants. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant for instance to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area, for instance to monitor the implant area of early stage infection or healing of a fusion procedure.Type: ApplicationFiled: August 12, 2016Publication date: August 16, 2018Inventors: Jeffrey ANKER, Caleb BEHREND, John DESJARDINS
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Publication number: 20160235158Abstract: Orthotics and methods for forming orthotics are described. The orthotics can be designed with a patient-specific design and can include variation in hardness across the orthotic so as to satisfy clinical need. An orthotic can be a custom-designed orthotic formed according to an additive manufacturing process such as a 3-D printing methodology. Through utilization of on-site formation methods such as 3-D printing, an orthotic can be designed, formed and fit at the point of care in a much shorter time period than traditional orthotics. The orthotics can include a layer that includes a plurality of cells across the layer. The layer can exhibit variable hardness across the layer through variation in cell void volume and optionally material of formation across the layer.Type: ApplicationFiled: February 18, 2016Publication date: August 18, 2016Inventors: John DesJardins, Scott Edward Stanley, Breanne Przestrzelski, Timothy C. Pruett, Steve L. Hoeffner, Brian Daryl Kaluf
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Publication number: 20150297873Abstract: A stabilization device is described that can be utilized to properly align and secure a percutaneous tube such as a chest tube following insertion. The device includes a central passage that is ridged for a tight friction fit with a percutaneous tube, a base that includes features to improve contouring and flexibility of the base with the skin surface of a patient and eyelets for suturing to the skin that include insets for secure placement of the suture. The device can be used without need of adhesive and can hold a percutaneous tube at a comfortable exit angle without placing undue stress upon the sutures holding the device.Type: ApplicationFiled: August 22, 2013Publication date: October 22, 2015Inventors: Brennen Crenshaw Jenkins, Lauren Elizabeth Eskew, Breanne Therese Przestrzelski, Carlyn Miller Atwood, Robert Gates, John Chandler, John Desjardins
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Patent number: 6939437Abstract: Methods of making paper or paperboard are described. In one method, at least one cellulytic enzyme composition and at least one cationic polymer composition are introduced to a paper making pulp at about the same time to form a treated pulp. The pulp may also be treated with at least one cationic starch. The resulting pulp is formed into a sheet of pulp. Other paper making processes are also described. A paper making apparatus is also described for carrying out the methods. Paper and paperboard made according to the methods are also described.Type: GrantFiled: November 13, 2000Date of Patent: September 6, 2005Assignee: Buckman Laboratories International, Inc.Inventors: Walter B. Hill, Jr., Richard L. Barclay, James A. O'Malley, Randall W. Conrod, John Desjardins, Roger M. Plourde