Abstract: Systems and methods for localized pseudo-continuous ASL (pCASL) of arterial blood local multi-coil arrays in an MRI system allow a series of pulses to selectively label blood with an on-resonance magnetic field in one or more arteries in a labeling plane while masking blood in others with an off-resonance magnetic field. This allows perfusion imaging and is well suited for imaging of cerebral blood flow.

Abstract: An embodiment of the invention includes a device, system and method for determining the characteristics of deep tissue. The novel method includes measuring blood flow rate and oxygenation characteristics of the tissue, and determining oxygen metabolism of the tissue as a function of the measure blood flow rate and measure oxygenation. The blow flow rate characteristics are measured as a function of light fluctuations caused by the tissue, while the oxygenation characteristics are measured as a function of transmission of light through the tissue with respect to the wavelength of light. The tissue may be layered tissue, for example, a portion of a brain. The tissue characteristics may be measured during times of varying levels of exercise intensity.