Patents by Inventor John Devane

John Devane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR MONITORING AND PREVENTING CLINICALLY SIGNIFICANT KETONE LEVELS IN PATIENTS RECEIVING DICHLOROACETATE CO-ADMINISTERED WITH A CARBOHYDRATE RESTRICTED DIET
    Publication number: 20250369974
    Abstract: Methods of controlling unhealthy levels of beta-hydroxybutyrate during dichloroacetate administration by managing diet are disclosed.
    Type: Application
    Filed: May 23, 2025
    Publication date: December 4, 2025
    Applicants: SAOL INTERNATIONAL DEVELOPMENT LTD., University of Florida Research Foundation, Incorporated
    Inventors: David PENAKE, Susan CLEMENT, John DEVANE, Sharon HAMM, Peter STACPOOLE, Richard WAGNER
  • Baclofen formulations and methods of minimizing patient exposure to metabolite variations
    Patent number: 12383522
    Abstract: Baclofen formulations, including formulations that minimize variability between doses, that minimize variation in patient exposure to baclofen metabolites, and are bioequivalent in regards to baclofen versus M1 metabolite ratios of baclofen tablets.
    Type: Grant
    Filed: November 14, 2023
    Date of Patent: August 12, 2025
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'Mahony, Sharon Hamm, John Devane, David Penake, Wolfgang Mohr, Manuel Weinheimer
  • METHODS OF IMPROVING SURVIVAL AND ELIMINATING TREATMENT-LIMITING TOXICITIES OF DICHLOROACETATE IN PATIENTS WITH PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY
    Publication number: 20250223628
    Abstract: Methods of improving survival and eliminating treatment-limiting toxicities of dichloroacetate (DCA) in patients with pyruvate dehydrogenase complex deficiency (PDCD).
    Type: Application
    Filed: January 7, 2025
    Publication date: July 10, 2025
    Applicants: SAOL INTERNATIONAL DEVELOPMENT LTD., University of Florida Research Foundation, Incorporated
    Inventors: David PENAKE, Sharon HAMM, Susan CLEMENT, John DEVANE, Peter STACPOOLE
  • Compositions and methods of administering baclofen
    Patent number: 12011502
    Abstract: Injectable baclofen formulations and methods that are bioequivalent in terms of plasma baclofen exposure to oral dosage forms but with reduced exposure ratios of baclofen to the M1 metabolite.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: June 18, 2024
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'Mahony, John Devane, Sharon Hamm, David Penake
  • Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
    Patent number: 11931328
    Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use. The composition may include the active ingredient dispersed throughout a matrix of the stabilizer. In some embodiments, the active ingredient and the stabilizer are intimately mixed in a matrix formulation. In some embodiments, the active ingredient is selected from 4 amino-3-(4-chlorophenyl)butanoic acid) (“baclofen”) and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: March 16, 2023
    Date of Patent: March 19, 2024
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: David Penake, Sharon Hamm, Leonard O'Mahony, John Devane, Wolfgang Mohr, Manuel Weinheimer
  • BACLOFEN FORMULATIONS AND METHODS OF MINIMIZING PATIENT EXPOSURE TO METABOLITE VARIATIONS
    Publication number: 20240082193
    Abstract: Baclofen formulations, including formulations that minimize variability between doses, that minimize variation in patient exposure to baclofen metabolites, and are bioequivalent in regards to baclofen versus M1 metabolite ratios of baclofen tablets.
    Type: Application
    Filed: November 14, 2023
    Publication date: March 14, 2024
    Applicant: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O’MAHONY, Sharon HAMM, John DEVANE, David PENAKE, Wolfgang MOHR, Manuel WEINHEIMER
  • Baclofen formulations and methods of minimizing patient exposure to metabolite variations
    Patent number: 11850225
    Abstract: Baclofen formulations, including formulations that minimize variability between doses, that minimize variation in patient exposure baclofen metabolites, and are bioequivalent in regards to baclofen versus M1 metabolite ratios of baclofen tablets.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: December 26, 2023
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'Mahony, Sharon Hamm, John Devane, David Penake, Wolfgang Mohr, Manuel Weinheimer
  • STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES
    Publication number: 20230218554
    Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use. The composition may include the active ingredient dispersed throughout a matrix of the stabilizer. In some embodiments, the active ingredient and the stabilizer are intimately mixed in a matrix formulation. In some embodiments, the active ingredient is selected from 4 amino-3-(4-chlorophenyl)butanoic acid) (“baclofen”) and its pharmaceutically acceptable salts.
    Type: Application
    Filed: March 16, 2023
    Publication date: July 13, 2023
    Applicant: AMNEAL PHARMACEUTICALS LLC
    Inventors: David PENAKE, Sharon HAMM, Leonard O’MAHONY, John DEVANE, Wolfgang MOHR, Manuel WEINHEIMER
  • COMPOSITIONS AND METHODS OF ADMINISTERING BACLOFEN
    Publication number: 20230201107
    Abstract: Injectable baclofen formulations and methods that are bioequivalent in terms of plasma baclofen exposure to oral dosage forms but with reduced exposure ratios of baclofen to the M1 metabolite.
    Type: Application
    Filed: November 9, 2022
    Publication date: June 29, 2023
    Applicant: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'MAHONY, John DEVANE, Sharon HAMM, David PENAKE
  • Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
    Patent number: 11654124
    Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use. The composition may include the active ingredient dispersed throughout a matrix of the stabilizer. In some embodiments, the active ingredient and the stabilizer are intimately mixed in a matrix formulation. In some embodiments, the active ingredient is selected from 4 amino-3-(4-chlorophenyl)butanoic acid) (“baclofen”) and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: May 23, 2023
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: David Penake, Sharon Hamm, Leonard O'Mahony, John Devane, Wolfgang Mohr, Manuel Weinheimer
  • BACLOFEN FORMULATIONS AND METHODS OF MINIMIZING PATIENT EXPOSURE TO METABOLITE VARIATIONS
    Publication number: 20230103372
    Abstract: Baclofen formulations, including formulations that minimize variability between doses, that minimize variation in patient exposure baclofen metabolites, and are bioequivalent in regards to baclofen versus M1 metabolite ratios of baclofen tablets.
    Type: Application
    Filed: July 11, 2022
    Publication date: April 6, 2023
    Applicant: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'MAHONY, Sharon HAMM, John DEVANE, David PENAKE
  • Compositions and methods of administering baclofen
    Patent number: 11523984
    Abstract: Injectable baclofen formulations and methods that are bioequivalent in terms of plasma baclofen exposure to oral dosage forms but with reduced exposure ratios of baclofen to the M1 metabolite.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: December 13, 2022
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'Mahony, John Devane, Sharon Hamm, David Penake
  • Baclofen formulations and methods of minimizing patient exposure to metabolite variations
    Patent number: 11491125
    Abstract: Baclofen formulations, including formulations that minimize variability between doses, that minimize variation in patient exposure to baclofen metabolites, and are bioequivalent in regards to baclofen versus M1 metabolite ratios of baclofen tablets.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: November 8, 2022
    Assignee: AMNEAL PHARMACEUTICALS LLC
    Inventors: Leonard O'Mahony, Sharon Hamm, John Devane, David Penake
  • STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES
    Publication number: 20220265588
    Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use. The composition may include the active ingredient dispersed throughout a matrix of the stabilizer. In some embodiments, the active ingredient and the stabilizer are intimately mixed in a matrix formulation. In some embodiments, the active ingredient is selected from 4 amino-3-(4-chlorophenyl)butanoic acid) (“baclofen”) and its pharmaceutically acceptable salts.
    Type: Application
    Filed: May 28, 2020
    Publication date: August 25, 2022
    Applicant: AMNEAL PHARMACEUTICALS LLC
    Inventors: David PENAKE, Sharon HAMM, Leonard O'MAHONY, John DEVANE, Wolfgang MOHR, Manuel WEINHEIMER
  • Injectable phenol formulations and methods of manufacture
    Patent number: 11083695
    Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 10, 2021
    Assignee: SAOL INTERNATIONAL DEVELOPMENT LTD.
    Inventors: Leonard O'Mahony, Sharon Hamm, John Devane, Imran Ahmed, David Penake
  • Injectable phenol formulations and methods of their use
    Patent number: 11083694
    Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 10, 2021
    Assignee: SAOL INTERNATIONAL DEVELOPMENT LTD.
    Inventors: Leonard O'Mahony, Sharon Hamm, John Devane, Imran Ahmed, David Penake
  • INJECTABLE PHENOL FORMULATIONS AND METHODS OF THEIR USE
    Publication number: 20210145766
    Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.
    Type: Application
    Filed: January 28, 2021
    Publication date: May 20, 2021
    Applicant: SAOL INTERNATIONAL DEVELOPMENT LTD.
    Inventors: Leonard O'MAHONY, Sharon HAMM, John DEVANE, Imran AHMED, David PENAKE
  • INJECTABLE PHENOL FORMULATIONS AND METHODS OF THEIR USE
    Publication number: 20210145767
    Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.
    Type: Application
    Filed: January 28, 2021
    Publication date: May 20, 2021
    Applicant: SAOL INTERNATIONAL DEVELOPMENT LTD.
    Inventors: Leonard O'MAHONY, Sharon HAMM, John DEVANE, Imran AHMED, David PENAKE
  • Injectable phenol formulations and methods of their use
    Patent number: 10959962
    Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: March 30, 2021
    Assignee: SAOL INTERNATIONAL DEVELOPMENT LTD.
    Inventors: Leonard O'Mahony, Sharon Hamm, John Devane, Imran Ahmed, David Penake
  • Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
    Patent number: 10792262
    Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: October 6, 2020
    Assignee: SAOL INTERNATIONAL LIMITED
    Inventors: David Penake, Sharon Hamm, Leonard O'Mahony, John Devane, Wolfgang Mohr, Manuel Weinheimer