Abstract: The invention relates to modulating the SIRP?-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRP? polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.

Abstract: There is disclosed herein composition, methods and uses relating to miR-126 as a measure of engraftment potential of a population of hematopoietic stem cells (HSCs), as a method of purifying HSCs and in the monitoring or treatment of acute myeloid leukemia.

Abstract: The present invention provides the use of an anti-CD44 antibody, a (Fab?)2, Fab, Fab? fragment thereof, an IgG or IgM isotype thereof, in a method for eradicating pathological stem cells in cancer therapy, and more specifically in breast cancer and leukaemia therapy.

Abstract: A display and method enable the auto-alignment and auto focus of an image onto a large screen in a projection display.

Abstract: There is disclosed an insert (2) for a conduit (4) adapted to effect helical flow in the conduit (4) comprising a longitudinally extending member having a helical formation.

Abstract: An air dryer tunnel, including an impingement section and an exhaust section. The impingement section may include a hot air inlet, and a corrugated impingement nozzle shroud including rows of orifices positioned at least one of at and proximate apexes of the corrugation of the nozzle shroud. The orifices may be in fluid communication with the hot air inlet. The exhaust section may include an exhaust air outlet in fluid communication with the orifices of the impingement nozzle shroud.

Abstract: An artificial or modified natural blood flow tubing has a helical-flow inducer to induce helical flow in such a fashion as to eliminate or reduce turbulence. One inducer is a tubular stent of expansible mesh having a helical vane.

Abstract: The present invention provides the use of an anti-CD44 antibody, a (Fab?)2, Fab, Fab? fragment thereof, an IgG or IgM isotype thereof, in the preparation of a medicament for eradicating pathological stem cells in cancer therapy, and more specifically in acute myeloid leukaemia therapy.

Abstract: The present invention provides the use of an anti-CD44 antibody, a (Fab?)2, Fab, Fab? fragment thereof, an IgG or IgM isotype thereof, in the preparation of a medicament for eradicating pathological stem cells in cancer therapy, and more specifically in acute myeloid leukaemia therapy.

Abstract: Processes and methods relating to treating contaminants and collecting desired substances from a zone of interest using subterranean collection and containment barriers. Tubular casings having interlock structures are used to create subterranean barriers for containing and treating buried waste and its effluents. The subterranean barrier includes an effluent collection system. Treatment solutions provided to the zone of interest pass therethrough and are collected by the barrier and treated or recovered, allowing on-site remediation. Barrier components may be used to in the treatment by collecting or removing contaminants or other materials from the zone of interest.

Abstract: The present invention provides the use of an anti-CD44 antibody, a (Fab?)2, Fab, Fab? fragment thereof, an IgG or IgM isotype thereof, in the preparation of a medicament for eradicating pathological stem cells in cancer therapy, and more specifically in acute myeloid leukaemia therapy.

Abstract: A helical formation (2) for a conduit (1). The helical formation (2) comprises an elongate member defining at least a portion of a helix, the elongate member comprising two inwardly extending portions (6, 7). The inwardly extending portions (6, 7) are spaced from each other and extend along the length of the elongate member in side-by-side relationship.

Abstract: A holder (2; 22; 82) for coating drill with a ceramic coating by a vapor deposition process has a perforated outer wall (4; 24; 84) into which the drills are inserted with their tips projecting. The holder has a hollow interior in which support means locate the inserted drills parallel and with their tips projecting to the same extent. The support means may comprise a correspondingly perforated inner wall (8; 26; 86) and a back wall (10; 28; 88) against which the drills abut, the outer, inner and back walls being parallel to each other. In one configuration, the holder has a hexagonal plan form with alternate outer walls (4) perforated and each with associated inner and back walls (8, 10). The holder is provided with a lid (52) that shields the interior from ingress of the coating material but provides an air passage to assist cooling of the portions of the drills in the holder interior after the coating has been applied.

Abstract: Systems and techniques for suppressing the carrier signal using an optical delay element and an electrical interferometer in an opto-electronic noise suppression module.

Abstract: A sapphire resonator for an ultrastable oscillator capable of substantial performance improvements over the best available crystal quartz oscillators in a compact cryogenic package is based on a compensation mechanism enabled by the difference between copper and sapphire thermal expansion coefficients for so tuning the resonator as to cancel the temperature variation of the sapphire's dielectric constant. The sapphire resonator consists of a sapphire ring separated into two parts with webs on the outer end of each to form two re-entrant parts which are separated by a copper post. The re-entrant parts are bonded to the post by indium solder for good thermal conductivity between parts of that subassembly which is supported on the base plate of a closed copper cylinder (rf shielding casing) by a thin stainless steel cylinder.

Abstract: There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

Abstract: There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

Abstract: There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

Abstract: Avermectins and milbemycins to treat endo- and ectoparasitic infestations in dogs.

Abstract: Microwave oscilltors incorporate r.f. feedback with carrier suppression to reduce phase noise. In a direct feedback oscillator arrngement a circulator is interposed between the r.f. amplifier and the high-Q resonator. The amplifier output is applied to the slightly over-coupled input port of the resonator so that the resultant net return signal is the vectorial difference between the signals emitted and reflected from the resonator. The gain of the r.f. amplifier is chosen to regenerate the forward signal from the net return signal. In a STALO-type arrangement, the resonator is critically coupled and an r.f. amplifier added to the path of the net return signal. The sensitivity of the STALO-type feedback loop is thereby enhanced while added amplifier noise is minimized by the superposition of the signals emitted by and reflected from the resonator.