Abstract: Delivery systems and methods of delivering devices or implants are disclosed. The devices or implants can be configured as valve repair devices or treatment devices have gripping members that are openable and closable to attach the device to leaflets of a native heart valve. The delivery systems are configured to position the device or implant and open and close the gripping members of the device or implant.

Abstract: The invention provides a solution for inadequate boundary layer testing methods. The invention includes a uniquely configured multi-module concentric loop cycling water past a testing module to obtain real-time values and variables to use in CFD calculations. The invention is comprised of various sections, specifically designed to support the entire system. The system includes: one or more water reservoirs/degassing tanks, high-capacity water pumps, water stream straightener(s), stable flow section, air induction ports, viewing ports, test modules containing test surfaces designed to measure friction and pressure of a passing water or air/water stream. The present invention includes one or more sensors on the test surface(s) that convey conditions to one or more computers that may receive, store, process and send interpretations to one or more visual monitors on or near the invention in real time.

Abstract: Methods, systems, and apparatus are described for transferring application data. In one aspect, a method includes causing, by a first component on a first device to establish a wireless connection with a second device; receiving, by the first component, first application data from the first application; receiving, by the first component, an indication that a user of the second device has approved a data transfer; and causing, by the first component, the first device to send the first application data to the second component running on the second device using the wireless connection.

Abstract: The present invention seeks to reduce the frictional resistance of a vessel through enhanced air lubrication by creating and sustaining a superaerophilic surface underneath the vessel. Air is supplied by two different means: through vents near the bow of the vessel and through the perforated superaerophilic surface underneath the vessel. The air delivered through the perforations in the superaerophilic surface prohibits wetting of microscopic structures on the surface, maintaining the superaerophilic properties of it. Since the superaerophilic surface attracts air close to the hull surface, this invention greatly increases the ratio of air from the bow vents within the boundary layer, improving the efficiency and effectiveness of the air lubrication system. Aerophilic effects are enhanced by carbon, which is captured, filtered, and mixed in with the air supplied to the plastron.

Abstract: The present disclosure relates to IL-34 antibodies, compositions comprising the same, and methods of using the antibodies and or compositions thereof for treating immune-mediated diseases such as neurodegenerative diseases, for example Alzheimer's Disease or a tauopathy disease.

Abstract: There is disclosed compositions and methods relating to anti-VEGFR2 antibodies. More specifically, there is disclosed fully human antibodies that bind VEGFR2, VEGFR2-binding fragments and derivatives of such antibodies, and VEGFR2-binding polypeptides comprising such fragments. Further still, there is disclosed antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having various cancers.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A concentrate composition comprising: (a) at least 0.1 wt % of a surfactant compound; and (b) at least 10 wt % one or more ingredients selected from aldehydes, succinimidyl esters, chelating agents and amine salts of carboxylic acids.

Abstract: Provided are methods and systems related to communications between a social media service or provider (e.g., Twitter®, Facebook®) or other resource (e.g., web page) and one or more content providers. In an aspect, provided are methods comprising receiving a request for content, wherein the request comprises a user agnostic identifier, determining user information associated with the request, determining time information associated with the request, determining media content associated with the user agnostic identifier based on the time information, determining one or more access rights to the media content based on the user information, and providing access to the media content based on the one or more access rights.

Abstract: There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that bind CD38, CD38-antibody binding fragments and derivatives of such antibodies, and CD38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

Abstract: The present invention seeks to reduce the frictional resistance of a vessel through enhanced air lubrication by creating and sustaining a superaerophilic surface underneath the vessel. Air is supplied by two different means: through vents near the bow of the vessel and through the perforated superaerophilic surface underneath the vessel. The air delivered through the perforations in the superaerophilic surface prohibits wetting of microscopic structures on the surface, maintaining the superaerophilic properties of it. Since the superaerophilic surface attracts air close to the hull surface, this invention greatly increases the ratio of air from the bow vents within the boundary layer, improving the efficiency and effectiveness of the air lubrication system. Aerophilic effects are enhanced by carbon, which is captured, filtered, and mixed in with the air supplied to the plastron.

Abstract: This invention introduces a unique two-piece nozzle used to provide air to the hull bottom of a ship, reducing the drag of water friction while in motion. The unique base assembly will mount flush in the bottom portion of a hull of a ship, creating no additional drag when closed. The unique interchangeable and modular nozzle design will allow for maintenance and or development of various designs in the water, without requiring a drydock visit. A flap portion of the nozzle insert will open when air is supplied, releasing small air bubbles to a ship's hull. The flap portion of the nozzle insert may incorporate various materials and passive closing schemes to adjust the air plastron. The present invention creates and maintains an air curtain, called plastron, delivering air underneath a ship hull through an array of nozzles.

Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.

Abstract: There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-L1, PD-L1-binding fragments and derivatives of such antibodies, and PD-L1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-L1 related disorders or conditions, including various inflammatory disorders and various cancers.

Abstract: An aqueous composition for forming a micro-fluid jet printable dielectric film layer, methods for forming dielectric film layers, and dielectric film layers formed by the method. The aqueous composition includes from about 5 to about 20 percent by 65 weight of a polymeric binder emulsion, from about 10 to about 30 percent by weight of a humectant, from about 0 to about 3 percent by weight of a surfactant, and an aqueous carrier fluid. The aqueous composition has a viscosity ranging from about 2 to about 6 centipoise at a temperature of about 23° C.

Abstract: In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

Abstract: There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies that bind CD123, CD123-antibody binding fragments and derivatives of such antibodies, and CD123-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

Abstract: Provided are methods and systems related to communications between a social media service or provider (e.g., Twitter®, Facebook®) or other resource (e.g., web page) and one or more content providers. In an aspect, provided are methods comprising receiving a request for content, wherein the request comprises a user agnostic identifier, determining user information associated with the request, determining time information associated with the request, determining media content associated with the user agnostic identifier based on the time information, determining one or more access rights to the media content based on the user information, and providing access to the media content based on the one or more access rights.

Abstract: Provided are methods and systems related to communications between a social media service or provider (e.g., Twitter®, Facebook®) or other resource (e.g., web page) and one or more content providers. In an aspect, provided are methods comprising receiving a request for content, wherein the request comprises a user agnostic identifier, determining user information associated with the request, determining time information associated with the request, determining media content associated with the user agnostic identifier based on the time information, determining one or more access rights to the media content based on the user information, and providing access to the media content based on the one or more access rights.