Abstract: Systems and methods for rapid calculation of parameters for delivering ultrasound energy to selected locations in the brain. An example method for delivering ultrasound energy to a region of a blood-brain barrier may comprise generating a model of the region of the blood-brain barrier and surrounding tissues. The method may also comprise determining a plurality of intermediate parameters by simulating acoustic paths of a plurality of ultrasound beams propagating from the region of the blood-brain barrier to a plurality of locations. The method may also comprise determining transmission parameters for ultrasound beams to be emitted from a plurality of ultrasound transducers based on the intermediate parameters and measured locations of the ultrasound transducers.

Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ?x,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ?x,vi.

Abstract: A multi-layer transducer operates with only one system channel per element. Passive switching connects the layers differently for transmit than for receive operation, such as connecting two layers in parallel for transmit and in series for receive. Any passive switching may be used, such as current and voltage limiting circuits. Tuning may be passively switched. Different tuning circuits are passively switched as a function of voltage level between transmit and receive operations.

Abstract: Ultrasound transducer temperatures are measured in response to a temperature dependent property of the ultrasound transducer. The temperature is measured without addition of new electronics or hardware retrofits of the transducer. By implementing software and/or hardware on the ultrasound system rather than the transducer, the temperature is measured in order to provide a level of fault protection. The upgraded or new ultrasound system uses either old or new transducers while still providing temperature measurement. For example, the temperature of the lens or window is measured as a function of changes in attenuation or acoustic velocity. The receive beamformer already implemented on many ultrasound systems is used to measure a temperature dependent property of the lens or window. As another example, the dielectric constant or capacitance of one or more transducer elements is measured using additional hardware in the ultrasound system.

Abstract: A multi-layer transducer operates with only one system channel per element. Passive switching connects the layers differently for transmit than for receive operation, such as connecting two layers in parallel for transmit and in series for receive. Any passive switching may be used, such as current and voltage limiting circuits. Tuning may be passively switched. Different tuning circuits are passively switched as a function of voltage level between transmit and receive operations.

Abstract: Ultrasound transducer temperatures are measured in response to a temperature dependent property of the ultrasound transducer. The temperature is measured without addition of new electronics or hardware retrofits of the transducer. By implementing software and/or hardware on the ultrasound system rather than the transducer, the temperature is measured in order to provide a level of fault protection. The upgraded or new ultrasound system uses either old or new transducers while still providing temperature measurement. For example, the temperature of the lens or window is measured as a function of changes in attenuation or acoustic velocity. The receive beamformer already implemented on many ultrasound systems is used to measure a temperature dependent property of the lens or window. As another example, the dielectric constant or capacitance of one or more transducer elements is measured using additional hardware in the ultrasound system.

Abstract: Ultrasound transducer temperatures are measured in response to a temperature dependent property of the ultrasound transducer. The temperature is measured without addition of new electronics or hardware retrofits of the transducer. By implementing software and/or hardware on the ultrasound system rather than the transducer, the temperature is measured in order to provide a level of fault protection. The upgraded or new ultrasound system uses either old or new transducers while still providing temperature measurement. For example, the temperature of the lens or window is measured as a function of changes in attenuation or acoustic velocity. The receive beamformer already implemented on many ultrasound systems is used to measure a temperature dependent property of the lens or window. As another example, the dielectric constant or capacitance of one or more transducer elements is measured using additional hardware in the ultrasound system.