Abstract: A method for system-specific analysis of an engine includes applying control inputs to the engine and an engine model and estimating outputs from the engine model based upon the control inputs. The method includes sensing outputs from the engine and analyzing residuals between estimated and sensed outputs. The method also includes customizing the engine model to reduce residuals for a particular engine and detecting the faults in the engine based upon the residuals for the particular engine.

Abstract: This invention relates to novel ?-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C—NH2 in which Xaa1 is G or D; Xaa3 is proline, hydroxyproline or glutamine; each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid; Xaa9 is proline, hydroxyproline or glutamine; Xaa10 is aspartate, glutamate or ?-carboxyglutamate; Xaa11 is optionally absent; and the C-terminus is optionally amidated, with the proviso that the peptide is not ?-conotoxin Ep1 or ?-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.