Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The invention provides a process and apparatus for forming an outwardly rolled lip on a cylindrical container body. The apparatus of the invention includes a mandrel having a cylindrical shaped portion and a lip forming annular cavity positioned coaxially with, and axially spaced from the cylindrical portion of the mandrel. The annular cavity has a generally semi-circular cross-section including an open mouth and a closed bottom extending outwardly of the mandrel. The mandrel additionally includes a radially tapered portion between the cylindrical portion and the lip forming die. The radially tapered portion tapers radially outwardly in the direction towards the lip forming die. An axial forcing means forces a cylindrical container body axially along the mandrel towards the lip forming die to thereby stretch the open end before the end is forced into the cavity and rolled outwardly.

Abstract: A compartmented composite container package is disclosed including a tubular composite body wall member closed at one end by a metal closure member, the one end of said body wall member containing a cup for receiving a first product, characterized by the provision of a separator member that is connected with the open end of the cup by a snap-fit connection to isolate the first product from a second product that is introduced into the remaining space within the tubular wall member via the other end thereof. In order to further isolate the products from each other, the separator includes a radially enlarged cylindrical flange portion that circumferentially engages the uniform cylindrical inner wall surface of the tubular body wall member, thereby to cooperate with the snap-fit connection to provide a double sealing result.

Abstract: An improved end seam construction for composite containers used in the packaging of hard to hold materials, such as materials under vacuum or pressure. The composite tubular body wall member includes at least one fibrous layer to the inner wall surface of which is bonded by a thermoplastic adhesive a metal liner layer that projects axially at at least one end a given distance beyond the fibrous layer. The end of the fibrous layer is deformed radially outwardly to define a funnel-shaped flange about which the projecting metal liner layer is deformed and compressed. The length of the projecting metal liner layer is such that when the metal-lined flange portion is connected by a rolled seam with the flange, the metal liner layer is compressed into surface-to-surface engagement with at least one surface of the curl portion of the metal end.