Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A loudspeaker has voice coil suspended in the gap of a frame and motor by a spider and cone. The spider is attached to the frame by a clamp. The frame has a pair of contact pads formed therein. First and second retainers on the frame and clamp are releasably engageable through a combined axial and rotational movement. The clamp when engaged holds the periphery of the spider against the frame and the leads of the voice coil against the contacts pads. Cam surfaces on the retainers create axial pressure to hold the spider against the frame.

Abstract: An improved multiple sample handling system, including a fully machine-compatible multiple sample support assembly, sample vortexing apparatus, and sample radioactivity sensing apparatus, is disclosed which enables performance of a complete radioimmunoassay or competitive binding procedure on the samples in the support assembly, generally without the need to remove and handle individual samples, and which greatly increases processing speed and error avoidance. The support assembly includes an apertured tray and sample retainers cooperating therewith and supporting the sample tubes by radially inwardly acting gripping portions. The retainers fit loosely within the tray apertures, but displacement control means are defined on the retainers and tray permitting the retainers together with tubes to smoothly move angularly relative to the tray within a small predetermined solid angle. The assembly with tubes is self-supporting upon the tubes for storage and optionally during sample operation.

Abstract: A machine for stripping automatically the sheath from metal cored cables comprises a pair of driving wheels for feeding the cable to be stripped through a nip between the wheels, one of the driving wheels having a fixed axis and the other driving wheel being movable linearly towards and away from the wheel with the fixed axis and being biassed towards it, and a pair of opposed cutting wheels each having a peripheral cutting edge projecting into the region of the nip substantially midway between the driving wheels so that, as the cable is fed through the nip, the sheath of the cable is slit by the cutting wheels continuously along the length of the cable on opposite sides of the cable to enable the sheath to separate from the core, the cutting wheels being linked to the movable driving wheel in such a way that when the movable driving wheel is displaced towards or away from the fixed driving wheel, the cutting wheels are simultaneously displaced in the same direction but through half the distance moved by the