Patents by Inventor John E. Casida
John E. Casida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6303638Abstract: Novel compounds are provided that modulate the neuronal nicotinic acetylcholine receptor (nAChR), particularly the mammalian nAChR (m-nAChR). The compounds are substituted pyridine derivatives such as analogs of 1-[(6-chloro-3-pyridinyl)methyl]-2-imidazolidine and 1-[(6-chloro-3-pyridinyl)methyl]-2-iminothiazole. Methods of using the novel m-nAChR modulators are also provided, including methods of using the compounds as m-nAChR probes and as therapeutic agents to treat mammalian individuals suffering from conditions, disorders or diseases that are responsive to administration of an m-nAChR modulator.Type: GrantFiled: August 20, 1999Date of Patent: October 16, 2001Assignee: The Regents of the University of CaliforniaInventors: Bachir Latli, John E. Casida
-
Patent number: 5502073Abstract: Compounds of the formula (I) ##STR1## which contain between 10 and 27 carbon atoms, and wherein m and n are independently selected from 0, 1 and 2; R.sup.2a is hydrogen, methyl, or ethyl; R.sup.2b is acetylene or contains between 3 and 18 carbon atoms and is a group R.sup.7, wherein R.sup.7 is a C.sub.1-13 non-aromatic hydrocarbyl group, optionally substituted by a cyano or C.sub.1-4 carbalkoxy group and/or by one or two hydroxy groups and/or by one to five halo atoms which are the same or different and/or by one to three groups R.sup.8 which are the same or different and each contain one to four hetero atoms, which are the same or different and are chosen from oxygen, sulphur, nitrogen and silicon, 1 to 10 carbon atoms and optionally 1 to 6 fluoro or chloro atoms or R.sup.2b is a 6-membered aromatic ring substituted by cyano and/or by one to three groups R.sup.8 and/or by a group --C.tbd.CH, --C.tbd.C-R.sup.7 or C.tbd.C-halo and/or by one to five halo atoms and/or by one to three C.sub.Type: GrantFiled: February 23, 1994Date of Patent: March 26, 1996Assignees: The Wellcome Foundation, The Regents of the University of CaliforniaInventors: John E. Casida, Michael Elliott, David A. Pulman
-
Patent number: 5371075Abstract: Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2,]-octanes and bicyclo-[2,2,3]-nonanes having 2 or 3 ring hetero atoms selected from O, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4-iodophenyl substituted compound or by debromination of the corresponding 4-dibromomethylphenyl substituted compound.Type: GrantFiled: July 29, 1992Date of Patent: December 6, 1994Assignees: Roussel-Uclaf, University of CaliforniaInventors: John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
-
Patent number: 5204333Abstract: The present invention provides compounds of the formula (I): ##STR1## wherein R is a phenyl group, substituted fluorine atoms formulations containing them and their use in controlling pest infestation.Type: GrantFiled: February 24, 1992Date of Patent: April 20, 1993Inventors: John P. Larkin, John B. Weston, Ian H. Smith, Christopher J. Palmer, John E. Casida
-
Patent number: 5157029Abstract: Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo-[2,2,3]-nonanes having 2 or 3 ring hetero atoms selected from O, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4-iodophenyl substituted compound or by debromination of the corresponding 4-dibromomethylphenyl substituted compound.Type: GrantFiled: August 2, 1991Date of Patent: October 20, 1992Assignee: The Regents of the University of CaliforniaInventors: John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
-
Patent number: 5061726Abstract: Pesticidally-active alkynylphenyl-substituted 1,3-oxathianes and related substituted compounds of the formula: ##STR1## and their use in controlling pests such as arthropods and helminths are described.Type: GrantFiled: April 26, 1990Date of Patent: October 29, 1991Assignee: The Regents of the University of CaliforniaInventors: Christopher J. Palmer, John E. Casida, John P. Larkin
-
Patent number: 5057508Abstract: Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo[2,2,3]-nonanes having 2 or 3 ring hetero atoms selected from O, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4-iodophenyl substituted compound or by debromination of the corresponding 4-dibromomethylphenyl substituted compound.Type: GrantFiled: February 20, 1990Date of Patent: October 15, 1991Assignee: The Regents of the University of CaliforniaInventors: John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
-
Patent number: 4985411Abstract: The present invention provides compounds of the formula (I): ##STR1## wherein m and n are independently selected from 0, 1 or 2, ##STR2## R is selected from hydrogen, methyl or ethyl; R.sup.1 is selected from C.sub.1-4 hydrocarbyl substituted by one to five halo atoms, and a group --C.tbd.C--R.sup.9 wherein R.sup.9 is a group S(O).sub.w --R.sup.10 wherein R.sup.10 is trifluoromethyl, methyl or ethyl and w is 0, 1 or 2 or R.sup.9 is a C.sub.3-5 aliphatic group or an aliphatic group containing up to 5 carbon atoms atoms substituted by C.sub.1-4 alkoxy, C.sub.2-6 alkoxyalkoxy, C.sub.1-8 acyloxy, halo or hydroxy, a group COR.sup.11 wherein R.sup.11 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or a group NR.sup.12 R.sup.13 wherein R.sup.12 and R.sup.13 are independently selected from hydrogen, methyl or ethyl, or R.sup.9 is SiR.sup.14 R.sup.15 R.sup.16 wherein R.sup.14 to R.sup.16 are the same or different and each is a C.sub.1-4 aliphatic group or R.sup.14 and R.sup.15 are C.sub.1-4 aliphatic groups and R.sup.Type: GrantFiled: November 29, 1989Date of Patent: January 15, 1991Assignees: The Wellcome Foundation Ltd., The Regents of the University of CaliforniaInventors: John E. Casida, Michael Elliott
-
Patent number: 4965257Abstract: Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo-[2,2,3]-nonanes, having 2 or 3 ring hetero atoms selected from O, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4-iodophenyl substituted compounds or by debromination of the corresponding 4-dibromomethylphenyl substituted compound.Type: GrantFiled: July 24, 1989Date of Patent: October 23, 1990Assignee: The Regents of the University of CaliforniaInventors: John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
-
Patent number: 4942173Abstract: The present invention relates to a compound of the formula (I): ##STR1## wherein R is C.sub.2-10 alkyl, alkenyl or alkynyl, each optionally substituted by or methyl substituted by cyano, C.sub.3-4 cycloalkyl, halo, C.sub.1-4 alkoxy or a group S(O)m R.sup.4 where R.sup.4 is C.sub.1-4 alkyl and m is 0, 1 or 2, or Ris C.sub.3-10 cycloalkyl, C.sub.4-10 cycloalkenyl or phenyl, each optionally substituted by C.sub.1-4 alkoxy, C.sub.1-3 alkyl, C.sub.2-4 alkynyl, halo, cyano or a group S(O)m R.sup.4 as defined hereinbefore; R.sup.1 is halo, C.sub.1-3 alkyl, C.sub.2-3 alkenyl or alkynyl each optionally substituted by halo, cyano, C.sub.1-4 alkoxy, alkyl carbalkoxy containing up to 6 carbon atoms, a group S(O)m R.sup.4 as defined hereinbefore or alkynyl substituted by tri-C.sub.1-4 alkylsilyl, or R.sup.1 is cyano, spiro-cyclopropyl, gem dimethyl, gem dicyano, gem diethynyl, oxo or methylene optionally substituted by cyano of C.sub.1-3 alkyl optionally substituted by fluorine, or R.sup.Type: GrantFiled: February 24, 1989Date of Patent: July 17, 1990Assignee: The Regents of the University of CaliforniaInventors: John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
-
Patent number: 4876274Abstract: A pesticidal composition comprising a compound having the formula R--C(CH.sub.2 O).sub.3 C--X wherein R and X are each organic substituents and wherein the compound has an LD.sub.50, in micrograms of compound per gram of body weight of a selected pest, of less than about 400 and/or an LD.sub.50 in the presence of synergist of less than about 20 is disclosed along with its use in killing pests. Pesticidal activity has been found against a broad range of types of insects. The pesticidal activity of the composition is strongly enhanced by the use of a selected synergist.Type: GrantFiled: August 27, 1986Date of Patent: October 24, 1989Assignee: The Regents of the University of CaliforniaInventors: Christopher J. Palmer, John E. Casida
-
Patent number: 4772624Abstract: A compound of the formula ##STR1## wherein R is C.sub.3 -C.sub.10 normal- or branched- alkyl or cycloalkyl, C.sub.3 -C.sub.10 normal- or branched- alkyl or cycloalkyl having one or more halogen, cyano, C.sub.1 -C.sub.2 partially or completely halogenated alkyl, or C.sub.1 -C.sub.3 alkoxy or partially or completely halogenated alkoxy substituents, C.sub.3 -C.sub.10 cycloalkyl having C.sub.1 -C.sub.2 alkyl substituents, phenyl, or phenyl having one or more halogen, cyano, nitro, ethynl, C.sub.1 -C.sub.2 alkyl or partially or completely halogenated alkyl, or C.sub.1 -C.sub.3 alkoxy or partially or completely halogenated alkoxy substituents; wherein at least one of R.sub.2 -R.sub.6 is ethynyl; and wherein the remainder of R.sub.2 -R.sub.6 are independently either hydrogen, halogen, C.sub.1 -C.sub.2 alkyl, partially or completely halogenated C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.3 alkoxy, partially or completely halogenated C.sub.1 -C.sub.3 alkoxy, ethynyl, nitro, cyano, or azido.Type: GrantFiled: September 23, 1985Date of Patent: September 20, 1988Assignee: The Regents of the University of CaliforniaInventors: Christopher J. Palmer, John E. Casida
-
Patent number: 4622315Abstract: A number of pyrethroid insecticides are photolabile, thus limiting their use outdoors. The non-photolabile pyrethroids often have the disadvantage of lasting too long when used outdoors. Herein, certain toxicologically acceptable compounds are designated which stabilize the normally photolabile pyrethroids and allow them to be used for an extended time period out of doors. The stabilizers have an electron deficient .pi. system and serve to decrease the rate of the photochemical decomposition of the pyrethroid at a given light level.Type: GrantFiled: February 10, 1983Date of Patent: November 11, 1986Assignee: The Regents of the University of CaliforniaInventors: Prem Dureja, John E. Casida, Luis O. Ruzo