Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: The new potato variety is classified as having no known parentage. It was discovered in a cultivated field of Butte variety potatoes near Ashton, Id. The new variety produces tubers that mature early and are suitable for fresh market use having high solids, low sugars, a fine mealy texture, good processing quality and good storability. The variety is resistant to metribuzin herbicide injury, leafroll net necrosis, veinal necrosis, jelly or sugar ends, second growths, growth cracking and black spot or shatter bruising. Its tubers are oblong to long, with shallow eyes, a smooth skin of moderate thickness, and exhibits moderate russeting. The tubers rarely express hollow heart, internal brown spot or other defects, and seldom develop storage rots. LC-1 is susceptible to most soilborne, foilage, and viral diseases, but is resistant to scab and seldom develops blackleg. The variety is well adapted to the sandy soils of the Western United States.

Abstract: A clutch pressure modifier valve for an automatic control circuit for a power transmission mechanism in a vehicle driveline wherein provision is made during ratio changes that requires engagement of a fluid pressure operated transmission clutch for modifying a clutch engagement pressure to compensate for the effect of centrifugal pressure build up in the pressure chamber of the clutch structure due to rotation of the clutch at high speeds during a shift interval whereby the timing of the clutch engagement is relatively independent of the rotary speed of the clutch during engagement and whereby the torque capacity of the clutch more closely matches the torque requirements of the driveline during ratio changes.