Patents by Inventor John E. Coligan

John E. Coligan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Induction of antigen-specific unresponsiveness by glioblastoma culture supernatants (GCS)
    Patent number: 6884413
    Abstract: The present invention concerns methods of specifically inhibiting an immune response of a subject to one or more selected antigens using an immunosuppressive composition derived from a glioblastoma cell line. The method steps include obtaining a population of antigen presenting cells (APCs); loading the APC population with specific antigens (in auto-immune diseases) or using donor APCs (for transplantation); incubating the APC population with the immunosuppressive composition; and introducing the incubated cells into the subject being treated. The APCs can be monocytes, macrophages, or dendritic cells. This method causes specific inhibition of the immune response because it induces apoptosis and/or anergy in the subject's T cells specific for antigens present on the APCs, but does not affect the immune response to antigens not present on the APC surfaces.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: April 26, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gene M. Shearer, Jian-Ping Zuo, John E. Coligan, Claire Chougnet