Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: A method and sensor or sensor subsystem permit improved evaporative leak detection in an automotive fuel system. The sensor or sensor subsystem computes temperature-compensated pressure values, thereby eliminating or reducing false positive or other adverse results triggered by temperature changes in the fuel tank. The temperature-compensated pressure measurement is then available for drawing an inference regarding the existence of a leak with reduced or eliminated false detection arising as a result of temperature fluctuations.

Abstract: A method and sensor or sensor subsystem permit improved evaporative leak detection in an automotive fuel system. The sensor or sensor subsystem computes temperature-compensated pressure values, thereby eliminating or reducing false positive or other adverse results triggered by temperature changes in the fuel tank. The temperature-compensated pressure measurement is then available for drawing an inference regarding the existence of a leak with reduced or eliminated false detection arising as a result of temperature fluctuations.

Abstract: A purge valve for an evaporative emission control system. The purge valve includes an actuator, a valve body, and a valve closure member disposed in the valve body. The actuator is disposed along a longitudinal axis, and includes an electromagnetic coil having a hollow core extending along the longitudinal axis, a stator disposed in the hollow core, and a permanent magnet armature disposed proximate the stator. The valve body is disposed proximate the actuator, and defines a flow passage extending along the longitudinal axis. When the coil is unenergized, the permanent magnet armature is magnetically attracted to the stator, and the valve closure member is spaced from the armature by a lost motion distance.

Abstract: A fuel system supplying fuel to an internal combustion engine of a vehicle. The fuel system includes an integrated pressure management system managing pressure and detecting leaks in the fuel system. The integrated pressure management system also performs a leak diagnostic for the headspace in a fuel tank, a canister that collects volatile fuel vapors from the headspace, a purge valve, and all associated hoses and connections.

Abstract: An integrated pressure management system manages pressure and detects leaks in a fuel system. The integrated pressure management system also performs a leak diagnostic for the head space in a fuel tank, a canister that collects volatile fuel vapors from the head space, a purge valve, and all associated.

Abstract: An integrated pressure management system manages pressure and detects leaks in a fuel system. The integrated pressure management system also performs a leak diagnostic for the headspace in a fuel tank, a canister that collects volatile fuel vapors from the headspace, a purge valve, and all associated hoses and connections.

Abstract: An integrated pressure management system manages pressure and detects leaks in a fuel system. The integrated pressure management system also performs a leak diagnostic for the head space in a fuel tank, a canister that collects volatile fuel vapors from the head space, a purge valve, and all associated.

Abstract: A method and sensor or sensor subsystem permit improved evaporative leak detection in an automotive fuel system. The sensor or sensor subsystem computes temperature-compensated pressure values, thereby eliminating or reducing false positive or other adverse results triggered by temperature changes in the fuel tank. The temperature-compensated pressure measurement is then available for drawing an inference regarding the existence of a leak with reduced or eliminated false detection arising as a result of temperature fluctuations.

Abstract: A method and sensor or sensor subsystem permit improved evaporative leak detection in an automotive fuel system. The sensor or sensor subsystem computes temperature-compensated pressure values, thereby eliminating or reducing false positive or other adverse results triggered by temperature changes in the fuel tank. The temperature-compensated pressure measurement is then available for drawing an inference regarding the existence of a leak with reduced or eliminated false detection arising as a result of temperature fluctuations.

Abstract: A leak detection monitor (22; 222) for an on-board evaporative emission leak detection system that detects leakage from an evaporative emission space of a fuel system of an automotive vehicle. One embodiment (22) utilizes engine intake system vacuum to vent the evaporative emission space to atmosphere when the engine is running; another (222), an electromagnet actuator (270, 280). Venting ceases when the engine is shut off. Changes in vapor pressure in the evaporative emission space are monitored over time by electric devices (74; 282) after the engine has been shut off to distinguish between a gross leak, a small leak smaller than a gross leak, and a leak that is at most smaller than a small leak.

Abstract: A method of calibrating an integrated pressure management apparatus having a chamber with an interior volume varying in response to fluid pressure in the chamber. A diaphragm partially defining the chamber is displaceable between first and second configurations in response to fluid pressure variations around a certain pressure level. A resilient element applies a force biasing the diaphragm a first configuration and a switch is actuated by the diaphragm in the second configuration. The method includes connecting the chamber to a pressure source at a known pressure level, and adjusting resilient element such that the switch is actuated at the known pressure level.

Abstract: A fuel system supplying fuel to an internal combustion engine of a vehicle. The fuel system includes an integrated pressure management system managing pressure and detecting leaks in the fuel system. The integrated pressure management system also performs a leak diagnostic for the headspace in a fuel tank, a canister that collects volatile fuel vapors from the headspace, a purge valve, and all associated hoses and connections.

Abstract: An integrated pressure management system manages pressure and detects leaks in a fuel system. The integrated pressure management system also performs a leak diagnostic for the head space in a fuel tank, a canister that collects volatile fuel vapors from the head space, a purge valve, and all associated.

Abstract: An integrated pressure management system manages pressure and detects leaks in a fuel system. The integrated pressure management system also performs a leak diagnostic for the head space in a fuel tank, a canister that collects volatile fuel vapors from the head space, a purge valve, and all associated.

Abstract: An integrated pressure management system manages pressure and detects leaks in a fuel system. The integrated pressure management system also performs a leak diagnostic for the head space in a fuel tank, a canister that collects volatile fuel vapors from the head space, a purge valve, and all associated.

Abstract: A fuel system supplying fuel to an internal combustion engine of a vehicle. The fuel system includes an integrated pressure management system managing pressure and detecting leaks in the fuel system. The integrated pressure management system also performs a leak diagnostic for the headspace in a fuel tank, a canister that collects volatile fuel vapors from the headspace, a purge valve, and all associated hoses and connections.

Abstract: A method and sensor or sensor subsystem permit improved evaporative leak detection in an automotive fuel system. The sensor or sensor subsystem computes temperature-compensated pressure values, thereby eliminating or reducing false positive or other adverse results triggered by temperature changes in the fuel tank. The temperature-compensated pressure measurement is then available for drawing an inference regarding the existence of a leak with reduced or eliminated false detection arising as a result of temperature fluctuations.

Abstract: A leak detection monitor (22; 222) for an on-board evaporative emission leak detection system that detects leakage from an evaporative emission space of a fuel system of an automotive vehicle. One embodiment (22) utilizes engine intake system vacuum to vent the evaporative emission space to atmosphere when the engine is running; another (222), an electromagnet actuator (270, 280). Venting ceases when the engine is shut off. Changes in vapor pressure in the evaporative emission space are monitored over time by electric devices (74; 282) after the engine has been shut off to distinguish between a gross leak, a small leak smaller than a gross leak, and a leak that is at most smaller than a small leak.

Abstract: A leak detection monitor (22; 222) for an on-board evaporative emission leak detection system that detects leakage from an evaporative emission space of a fuel system of an automotive vehicle. One embodiment (22) utilizes engine intake system vacuum to vent the evaporative emission space to atmosphere when the engine is running; another (222), an electromagnet actuator (270, 280). Venting ceases when the engine is shut off. Changes in vapor pressure in the evaporative emission space are monitored over time by electric devices (74; 282) after the engine has been shut off to distinguish between a gross leak, a small leak smaller than a gross leak, and a leak that is at most smaller than a small leak.