Patents by Inventor John E. Davies

John E. Davies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090285842
    Abstract: Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also employ soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like.
    Type: Application
    Filed: May 4, 2007
    Publication date: November 19, 2009
    Inventors: John E. Davies, Jane Ennis, Alejandro Gomez-Aristiz-Abal, Dolores Baksh
  • Publication number: 20090275127
    Abstract: Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted progenitor cells are HUCPVCs.
    Type: Application
    Filed: December 21, 2006
    Publication date: November 5, 2009
    Inventors: Jane Ennis, Rahul Sarugaser, John E. Davies
  • Publication number: 20090269318
    Abstract: Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC?/? progenitor cells, and is useful to grow and repair human tissues including bone.
    Type: Application
    Filed: June 11, 2009
    Publication date: October 29, 2009
    Applicant: Tissue Regeneration Therapeutics, Inc.
    Inventors: John E. Davies, Dolores Baksh, Rahul Sarugaser, Morris Hosseini, Antony D.S. Lickorish
  • Patent number: 7547546
    Abstract: Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC?/? progenitor cells, and is useful to grow and repair human tissues including bone.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: June 16, 2009
    Assignee: Tissue Regeneration Therapeutics Inc.
    Inventors: John E. Davies, Dolores Baksh, Rahul Sarugaser, Morris Hosseini, Antony D. S. Lickorish
  • Publication number: 20080113434
    Abstract: Non-hematopoietic, e.g., mesenchymal progenitor cells, are expanded under non-static, non-adherent conditions in serum-deprived medium.
    Type: Application
    Filed: March 4, 2005
    Publication date: May 15, 2008
    Inventors: John E. Davies, Dolores Baksh, Peter Zandstra
  • Patent number: 7022522
    Abstract: A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth. The polymer scaffold may be produced using pure polymer or alternatively a composite material may be formed consisting of a macroporous polymer scaffold and osteoclast-resorbable calcium phosphate particles with a binding agent binding the calcium phosphate particles to the polymer scaffold.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: April 4, 2006
    Inventors: Limin Guan, Chantal E. Holy, Molly S. Shoichet, John E. Davies
  • Patent number: 6875442
    Abstract: A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: April 5, 2005
    Assignee: Bonetec Corporation
    Inventors: Chantal E. Holy, Molly S. Shoichet, John E. Davies
  • Publication number: 20040137612
    Abstract: Described is a method of expanding human progenitor calls by suspension culturing under non-static conditions. The culturing method provides a three-dimensional space for the rapid expansion of desirable progenitors. By this method, a new compartment of multipotential progenitor cells has been identified, which give rise under differentiation conditions to progeny including osteoblasts, chondrocytes, myoblasts, adipocytes, and other non-hematopoietic cell types. Their use in cell and tissue-based engineering is described.
    Type: Application
    Filed: October 24, 2003
    Publication date: July 15, 2004
    Inventors: Dolores Baksh, John E. Davies, Peter Zandstra
  • Publication number: 20030082808
    Abstract: A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth. The polymer scaffold may be produced using pure polymer or alternatively a composite material may be formed consisting of a macroporous polymer scaffold and osteoclast-resorbable calcium phosphate particles with a binding agent binding the calcium phosphate particles to the polymer scaffold.
    Type: Application
    Filed: April 30, 2002
    Publication date: May 1, 2003
    Inventors: Limin Guan, Chantal E. Holy, Molly S. Shoichet, John E. Davies
  • Publication number: 20030008395
    Abstract: A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth.
    Type: Application
    Filed: August 13, 2002
    Publication date: January 9, 2003
    Inventors: Chantal E. Holy, Molly S. Shoichet, John E. Davies
  • Patent number: 6472210
    Abstract: A polymer scaffold is provided having an extensively interconnected macroporous network with macropores having microporous struts as walls. Macropore diameter ranges from about 0.5 to about 3.5 mm. The polymer may be a biocompatible, biodegradable polymer such as poly(lactide-co-glycolide) containing 75% polylactide and 25% polyglycolide. The polymer scaffold is prepared by mixing a liquid polymer with particles, precipitating the liquid polymer with a non-solvent for the liquid polymer and dissolving the particles with a solvent to form the macroporous polymer scaffold which preferably has porosity greater than 50%. The surface of the polymer scaffold may be modified by acid or base treatment, or by collagen or calcium phosphate deposition. The polymer scaffold has utility for tissue engineering, particularly as a scaffold for in vitro and in vivo cell growth.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: October 29, 2002
    Assignee: Bonetec Corporation
    Inventors: Chantal E. Holy, Molly S. Shoichet, John E. Davies
  • Patent number: 6379962
    Abstract: A polymer scaffold is provided having an extensively interconnected macroporous network with macropores having microporous struts as walls. Macropore diameter ranges from about 0.5 to about 3.5 mm. The polymer may be a biocompatible, biodegradable polymer such as poly(lactide-co-glycolide) containing 75% polylactide and 25% polyglycolide. The polymer scaffold is prepared by mixing a liquid polymer with particles, precipitating the liquid polymer with a non-solvent for the liquid polymer and dissolving the particles with a solvent to form the macroporous polymer scaffold which preferably has porosity greater than 50%. The surface of the polymer scaffold may be modified by acid or base treatment, or by collagen or calcium phosphate deposition. The polymer scaffold has utility for tissue engineering, particularly as a scaffold for in vitro and in vivo cell growth.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: April 30, 2002
    Assignee: Bonetec Corporation
    Inventors: Chantal E. Holy, Molly S. Shoichet, John E. Davies
  • Patent number: 6271756
    Abstract: A security tag detection and localization system for detecting a resonant security tag in a security zone comprising a Plurality of detection zones, and generating an alarm signal localizing the resonant security tag to a detection zone. The system includes an antenna array for radiating interrogation signals and receiving response signals. The antenna array forms the upper boundary, the lower boundary or both the upper and lower boundaries of a security zone and extends horizontally across the width and length of the security zone. The antenna array comprises at least two antennas. The antennas forming the upper and lower boundaries are disposed side-by-side in a single horizontal plane with each antenna being electromagnetically coupled to one of the detection zones.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: August 7, 2001
    Assignee: Checkpoint Systems, Inc.
    Inventors: John E. Davies, Jr., Eric A. Eckstein, Edwin H. Hopton, Jr., William S. Richie, Jr.
  • Patent number: 5849569
    Abstract: A calcium phosphate based thin film on which bone cells may be cultured to permit evaluation of bone cell functional properties comprises calcium phosphate entities which provide for varying degrees of resorption of the calcium phosphate entities in evaluating the functional properties. The film is sufficiently thin that resorption of the entities can be detected. Such film, as applied to a support, is a very useful analytical component for evaluating such bone cell functional characteristics. An analytical device, which may be used in an analytical kit, can be provided having a plurality of wells with the devices located at the bottom thereof. A process is provided for making the film and especially the film which has a combination of calcium hydroxyapatite with tricalcium phosphate.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: December 15, 1998
    Assignee: Millenium Biologix, Inc.
    Inventor: John E. Davies
  • Patent number: 4190683
    Abstract: A method of forming an improved liquid phase epitaxial film on a wafer. The resultant film has improved uniformity of magnetic properties, such as the collapse field (H.sub.o), across the surface of the wafer as well as being substantially free of mesa defects on the surface. The method includes the step of growing the liquid phase epitaxial film while the wafer is in the horizontal plane. The wafer is removed from the melt while the wafer is tilted at an angle from the horizontal plane so that the melt may drain from the wafer. Then the wafer is positioned in a horizontal plane again and rotated to remove the remaining melt droplets from the edge of the wafer. In a preferred embodiment, a plurality of wafers are positioned in a wafer holding means so that the wafers are arranged in a stacked manner having substantially the same space between adjacent wafers. Wafers may also be stacked in pairs that are back-to-back while carrying out this method.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: February 26, 1980
    Assignee: International Business Machines Corporation
    Inventors: John E. Davies, Guido Galli
  • Patent number: 4077832
    Abstract: A method of growing a monocrystalline bismuth rare earth iron garnet material from a melt in which a flux containing bismuth oxide and an alkali metal oxide is employed.
    Type: Grant
    Filed: October 6, 1976
    Date of Patent: March 7, 1978
    Assignee: U.S. Philips Corporation
    Inventors: John M. Robertson, John C. Brice, John E. Davies