Patents by Inventor John E. G. Kemp

John E. G. Kemp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain 1-azabicyclo[2.2.1]heptanes useful as muscarinic receptor antagonists
    Patent number: 5397800
    Abstract: MUSCARINIC RECEPTOR ANTAGONISTS OF THE FOLLOWING FORMULAE: ##STR1## Muscarinic receptor antagonists, useful especially in the treatment of irritable bowel syndrome, of formula (IA) or (IB) or a pharmaceutically acceptable salt thereof, where R.sup.2 and R.sup.3 are each independently H, halo or C.sub.1 -C.sub.4 alkyl; m is 0, 1 or 2; n is 1, 2 or 3; Y is a direct link, O or S; with the proviso that when n is 1, Y is a direct link; Het is a group of formula (A) or (B), where p is 0, 1 or 2, q is 1, 2 or 3, and r is 0, 1, 2 or 3, with the proviso that the sum of p, q and r is at least 3, the N atom of "Het" being attached to the group (CH.sub.2).sub.n in formula (IA) and to the H atom in formula (IB); and R.sup.1 is a group of formula (a), (b) or Het.sup.1, where R.sup.4 and R.sup.5 are each independently H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --(CH.sub.2).sub.t OH, halo, trifluoromethyl, cyano, --(CH.sub.2).sub.t NR.sup.6 R.sup.7, --CO(C.sub.1 -C.sub.4 alkyl), --OCO(C.sub.1 -C.sub.
    Type: Grant
    Filed: June 22, 1992
    Date of Patent: March 14, 1995
    Assignee: Pfizer Inc.
    Inventors: David Alker, Peter E. Cross, John E. G. Kemp
  • 4-Substituted-1-(4-alkylsulphonamidophenyl)piperazines as antiarrhythmic agents
    Patent number: 4797401
    Abstract: Antiarrhythmic agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R and R.sup.1, which are the same or different, are C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl, --CH.sub.2 CH.sub.3, --CH.sub.2 Cl, --CF.sub.3 or --NH.sub.2 ;R.sup.2 and R.sup.3, which are the same or different, are H, halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; andX is --CH.sub.2 --, ##STR2## or --CH(OH)--.
    Type: Grant
    Filed: July 15, 1987
    Date of Patent: January 10, 1989
    Assignee: Pfizer Inc.
    Inventors: John E. G. Kemp, Peter E. Cross
  • 6-Perhaloalkylsulfonyloxy-penicillanic acids and derivatives thereof
    Patent number: 4356122
    Abstract: 6-Alpha and 6-beta-substituted penicillanic acid derivatives of the formula: ##STR1## wherein R is H or a conventional penicillin carboxy protecting group or an ester forming residue readily hydrolyzable in vivo and R.sup.1 is a perhaloalkyl group of from 1 to 4 carbon atoms wherein the halogen atoms are fluoro or chloro, undergo SN.sub.2 nucleophilic displacement with halide or azide ions with inversion of configuration at C-6 to yield the corresponding 6-beta or 6-alpha-halo- or azido-substituted product.
    Type: Grant
    Filed: December 10, 1980
    Date of Patent: October 26, 1982
    Assignee: Pfizer Inc.
    Inventor: John E. G. Kemp
  • Tetrahydro-carbazole derivatives as gastric anti-secretory agents
    Patent number: 3970757
    Abstract: Novel-3-alkyl-9-aminoalkyl-1,2,3,4-tetrahydrocarbazoles having gastric anti-secretory activity are prepared. A typical embodiment is 3-tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole.
    Type: Grant
    Filed: October 15, 1975
    Date of Patent: July 20, 1976
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson, John E. G. Kemp
  • Tetrahydro-carbazole derivates
    Patent number: 3931222
    Abstract: Novel 3-alkyl-9-aminoalkyl-1,2,3,4-tetrahydrocarbazoles having gastric anti-secretory activity are prepared. A typical embodiment is 3-tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole.
    Type: Grant
    Filed: May 29, 1974
    Date of Patent: January 6, 1976
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson, John E. G. Kemp